Author Correction: Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis

Waage, Johannes; Standl, Marie; Curtin, John A.; Jessen, Leon Eyrich; Thorsen, Jonathan; Tian, Chao; Schoettler, Nathan; Flores, Carlos; Abdellaoui, Abdel; Ahluwalia, Tarunveer S.; Alves, Alexessander Couto; Amaral, André F.S.; Antó, Josep M.; Arnold, Andreas; Barreto-Luis, Amalia; Baurecht, Hansjörg; Beijsterveldt, Catharina E. M. van; Bleecker, Eugene R.; Bonàs-Guarch, Sílvia; Boomsma, Dorret I.; Pedersen, Susanne Brix; Bunyavanich, Supinda; Burchard, Esteban G.; Chen, Zhanghua; Ivan, Cristina; Čustović, Adnan; Dekker, Herman T. den; Dharmage, Shyamali; Dmitrieva, Julia; Duijts, Liesbeth; Ege, Markus; Gauderman, W. James; Georges, Michel; Gieger, Christian; Gilliland, Frank D.; Granell, Raquel; Gui, Hongsheng; Hansen, Torben; Heinrich, Joachim; Henderson, John; Hernandez‐Pacheco, Natalia; Holt, Patrick G.; Imboden, Medea; Jaddoe, Vincent W. V.; Järvelin, Marjo‐Riitta; Jarvis, Deborah; Jensen, Kamilla Kjærgaard; Jónsdóttir, Ingileif; Kabesch, Michael; Kaprio, Jaakko; Kumar, Ashish; Lee, Youngae; Levin, Albert M.; Li, Xingnan; Lorenzo-Díaz, Fabián; Mercader, Josep M.; Meyers, Deborah A.; Myers, Rachel A.; Nicolae, Dan L.; Nøhr, Ellen A.; Palviainen, Teemu; Paternoster, Lavinia; Pennell, Craig E.; Pershagen, Göran; Pino-Yanes, María; Probst‐Hensch, Nicole; Rüschendorf, Franz; Simpson, Angela; Stefánsson, Kāri; Sunyer, Jordi; Sveinbjörnsson, Garðar; Thiering, Elisabeth; Thompson, Philip J.; Torrent, Maties; Torrents, David; Tung, Joyce Y.; Wang, Carol A.; Weidinger, Stephan; Weiss, Scott T.; Williams, L. Keoki; Ober, Carole; Hinds, David A.; Ferreira, Manuel; Bisgaard, Hans; Strachan, David P.; Bønnelykke, Klaus

doi:10.1038/s41588-018-0197-6

Cited by 4 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…39,40 Clinically, AR patients with allergic dermatitis, AR also has its own genetic susceptibility sites, reflecting the specificity of different tissues to allergens. [41][42][43] Age also has an important impact on AR. Intrauterine growth restriction has a protective effect on human allergic diseases, and foetal oxidative balance (protective prenatal factors counteract oxidative stressors) may play a key role in the prevention of asthma and allergic diseases.…”

Section: Other Risk Factors Of Armentioning

confidence: 99%

“…In terms of genetic factors, up to 160 AR susceptible loci have been found in recent genome‐wide association studies studies; with most of these genes being enriched in cytokines and immune regulatory pathways. Although genetic sites of AR share the same genetic basis with asthma and allergic dermatitis, AR also has its own genetic susceptibility sites, reflecting the specificity of different tissues to allergens 41‐43 . Age also has an important impact on AR.…”

Section: Mechanismsmentioning

confidence: 99%

See 1 more Smart Citation

Advances and novel developments in allergic rhinitis

Meng

Wang

Zhang

2020

Allergy

View full text Add to dashboard Cite

Allergic rhinitis (AR) is an upper airway disease with high prevalence in the world, and therefore needs to be thoroughly investigated and treated accordingly. Although the mechanisms underlying the pathology and treatment of AR have been widely studied, many aspects of AR are still unclear and warrant further investigations. The purpose of the present review was therefore to report recently published papers, which highlight the novel mechanisms and treatments of AR. These include role of environment, important proteins and cells, and some other factors in the pathogenesis of AR; as well as the role of immunotherapy and biologics in the treatment of AR.

show abstract

Section: Other Risk Factors Of Armentioning

confidence: 99%

Section: Mechanismsmentioning

confidence: 99%

Advances and novel developments in allergic rhinitis

Meng

Wang

Zhang

2020

Allergy

View full text Add to dashboard Cite

show abstract

“…(which was not certified by peer review) Published summary GWAS results were available for the most recent GWAS for the broad allergic disease phenotype (n=360,868), which had considered the existence of any one of the atopic triad (asthma, AD and hay fever) 18 . Summary GWAS results were also available for asthma (n=127,669) 19 , hay fever (n=38,838) 20 , and AD (n=40,835) 21 . Similarly, published GWAS results were available for the mental health outcomes investigated; major depressive disorder (MDD) 22 , bipolar disorder 23 , schizophrenia 24 , neuroticism 25 and anxiety 26 .…”

Section: Study Populationsmentioning

confidence: 99%

“…A genetic instrument was defined for the broad allergic disease phenotype using 89 independent (r 2 < 0.01) single-nucleotide polymorphisms (SNPs) from loci reported to be most strongly associated (P < 5x10 -8 ) by Ferreira and colleagues 18 . Genetic instruments were also defined for asthma (16 SNPs) 19 , AD (23 SNPs) 21 and hay fever (37 SNPs) 20 using independent (r 2 < 0.01) SNPs associated at the genome-wide significance threshold (P<5×10 -8 ) from the largest GWAS of these conditions (see Tables E1 to E4 in the Online Repository). Effect sizes for each of these SNPs were extracted from recent GWAS of each mental health phenotype to create our outcome datasets.…”

Section: Analysis Of Causal Relationshipsmentioning

confidence: 99%

Investigating the causal relationship between allergic disease and mental health

Budu-Aggrey

Joyce

Davies

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

Background Observational studies have reported an association between allergic disease and mental health, but a causal relationship has not been established. Objective To use Mendelian Randomization (MR) to investigate a possible causal relationship between atopic disease and mental health phenotypes. Methods The observational relationship between allergic disease and mental health was investigated in UK Biobank. The direction of causality was investigated with bidirectional two-sample MR using summary-level data from published genome-wide association studies. A genetic instrument was derived from associated variants for a broad allergic disease phenotype to test for causal relationships with various mental health outcomes. Genetic instruments were also derived for mental health conditions to assess causality in the reverse direction. We also investigated if these relationships were specific to atopic dermatitis (AD), asthma or hay fever. Results The broad allergic disease phenotype was phenotypically associated with most measures of mental health, but we found little evidence of causality in either direction. However, we did find evidence of genetic liability for bipolar disorder causally influencing hay fever risk (OR=0.94 per doubling odds of bipolar disorder risk; 95%CI=0.90-0.99; P-value=0.02), but evidence of a phenotypic association was weak. Conclusions Few of the phenotypic associations between allergic disease and mental health were replicated. Any causal effects we detected were considerably attenuated compared to the phenotypic association. This suggests that most co-morbidity observed clinically is unlikely to be causal.

show abstract

“…The fruit fly, Drosophila melanogaster , is a key model for invertebrate vision research 1 . The small diameters of cells in the early visual neuropil have long limited electrophysiological approaches to recording neural activity in the optic lobes, a problem recently overcome with advances in technology and genetic tools that make functional imaging methods possible 2 – 4 . Though these imaging methods have facilitated extensive characterisation of motion vision in flies 5 , how flies process colour information, or how the spectral content of light affects other visual modalities, remains largely unknown.…”

Section: Introductionmentioning

confidence: 99%

A novel setup for simultaneous two-photon functional imaging and precise spectral and spatial visual stimulation in Drosophila

Feord

Wardill

2020

Sci Rep

View full text Add to dashboard Cite

Motion vision has been extensively characterised in Drosophila melanogaster, but substantially less is known about how flies process colour, or how spectral information affects other visual modalities. To accurately dissect the components of the early visual system responsible for processing colour, we developed a versatile visual stimulation setup to probe combined spatial, temporal and spectral response properties. Using flies expressing neural activity indicators, we tracked visual responses in the medulla, the second visual neuropil, to a projected colour stimulus. The introduction of custom bandpass optical filters enables simultaneous two-photon imaging and visual stimulation over a large range of wavelengths without compromising the temporal stimulation rate. With monochromator-produced light, any spectral bandwidth and centre wavelength from 390 to 730 nm can be selected to produce a narrow spectral hue. A specialised screen material scatters each band of light across the visible spectrum equally at all locations of the screen, thus enabling presentation of spatially structured stimuli. We show layer-specific shifts of spectral response properties in the medulla correlating with projection regions of photoreceptor terminals.

show abstract

Author Correction: Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis

Abstract: In the version of this article initially published, in Fig. 3, the y-axis numbering did not match the log scale indicated in the axis label. The error has been corrected in the HTML and PDF version of the article.

Cited by 4 publications

References 0 publications

Advances and novel developments in allergic rhinitis

Advances and novel developments in allergic rhinitis

Investigating the causal relationship between allergic disease and mental health

A novel setup for simultaneous two-photon functional imaging and precise spectral and spatial visual stimulation in Drosophila

Contact Info

Product

Resources

About