Author Correction: G Protein-Coupling of Adhesion GPCRs ADGRE2/EMR2 and ADGRE5/CD97, and Activation of G Protein Signalling by an Anti-EMR2 Antibody

Bhudia, Nisha; Desai, Sapna; King, Natalie D.; Ancellin, Nicolas; Grillot, Didier; Barnes, Ashley; Dowell, Simon J.

doi:10.1038/s41598-020-62011-0

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Specific Adhesion G Protein-coupled Receptors In Gbm1

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“… 84 Nevertheless, CD97 has also been shown to couple with other G protein signaling pathways, such as G βγ 85 and G z , where it dampens cAMP levels. 86 …”

Section: Specific Adhesion G Protein-coupled Receptors In Gbmmentioning

confidence: 99%

Adhesion G protein-coupled receptors in glioblastoma

Stephan

Ravn-Boess

Placantonakis

2021

Neuro-Oncology Advances

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Members of the adhesion family of G protein-coupled receptors (GPCRs) have received attention for their roles in health and disease, including cancer. Over the past decade, several members of the family have been implicated in the pathogenesis of glioblastoma. Here, we discuss the basic biology of adhesion GPCRs and review in detail specific members of the receptor family with known functions in glioblastoma. Finally, we discuss the potential use of adhesion GPCRs as novel treatment targets in neuro-oncology.

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“… 84 Nevertheless, CD97 has also been shown to couple with other G protein signaling pathways, such as G βγ 85 and G z , where it dampens cAMP levels. 86 …”

Section: Specific Adhesion G Protein-coupled Receptors In Gbmmentioning

confidence: 99%