Author Correction: Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma

Chen, Huihui; Cho, Kin‐Sang; Vu, T. H. Khanh; Shen, Ching-Hung; Kaur, Mandeep; Chen, Guochun; Mathew, Rose; McHam, M. Lisa; Fazelat, Ahad; Lashkari, Kameran; Au, Ngan Pan Bennett; Tse, Joyce Ka Yu; Li, Yingqian; Yu, Honghua; Yang, Lanbo; Stein‐Streilein, Joan; Eddie, Chi Him; Woolf, Clifford J.; Whary, Mark T.; Jager, Martine J.; Fox, James G.; Chen, Jianzhu; Chen, Dong F.

doi:10.1038/s41467-018-06428-2

Cited by 10 publications

(12 citation statements)

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“…In addition, it has been reported previously that endothelial cells of TM can secrete various factors and cytokines which play a pivotal role in regulation and modulation of ECM remodeling, and therefore affect the pathway of AH outflow (20,21). Most recently, specific HSP-T cell response has been reported to play a pivotal role in IOP-independent glaucoma progression (22). Therefore, we hypothesize that immune factors may be the cause rather than the result of glaucoma in SWS patients.…”

Section: Introductionmentioning

confidence: 83%

Characteristic Cytokine Profiles of Aqueous Humor in Glaucoma Secondary to Sturge-Weber Syndrome

Peng

Ding

et al. 2020

Front. Immunol.

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Patients with Sturge-Weber syndrome (SWS) are susceptible to ocular complications, and among them, glaucoma is one of the most frequent forms. In current study, we utilized multiplex human cytokine antibody array to simultaneously measure the concentration of 40 cytokines in aqueous humor (AH) of patients with SWS-induced glaucoma (SG), or from patients with senile cataract as controls. Compared with the control group, levels of interleukin (IL)-12p40, macrophage inflammatory protein (MIP)-1d, tumor necrosis factor-alpha (TNF-a), IL-5, IL-7, interleukin-6 receptor (IL-6R), and B lymphocyte chemoattractant (BLC) in AH were significantly higher in SG group. Samples from SG patients displayed significantly lower levels of MIP-1b, IL-6, MIP-1a, and monocyte chemoattractant protein (MCP)-1 than controls. Further analysis showed that IL-7, MIP-1a, TNF-a were positively correlated with intraocular pressure (IOP) in patients with early-onset SG. Moreover, IL-12p40 was negatively correlated with age in patients with SG. These cytokines may make contributions to the immunopathogenesis or progression of glaucoma in patients with SWS.

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Section: Introductionmentioning

confidence: 83%

Characteristic Cytokine Profiles of Aqueous Humor in Glaucoma Secondary to Sturge-Weber Syndrome

Peng

Ding

et al. 2020

Front. Immunol.

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“…In contrast to the innate immune system, the adaptive immune system requires up to 7 days to be activated. Recent report on the involvement of heat shock protein (HSP)-specific T cells offers the key evidence support a role for autoimmunity in glaucoma (30). However, analysis of T cells in patients and experimental models of glaucoma remains limited; there are only few studies focusing on the presence of specific T lymphocyte subsets in the sera of glaucoma patients.…”

Section: Involvement Of T Cells In Glaucomamentioning

confidence: 99%

“…In part, this is because pathogenic antigens in the retina are long thought to induce T regulatory (Treg) cells through a mechanism of ACAID, therefore maintaining the ocular immune privilege. Recent studies of the peripheral blood of glaucoma patients revealed that the immunity activated in glaucoma may not be counterbalanced by an efficient immune suppression (30,31). Patients with glaucoma exhibited a trend of decreased frequency of Treg and their CD4+ T cells presented a greater stimulation response characterized by increased proliferation and proinflammatory cytokine secretion.…”

Section: Involvement Of T Cells In Glaucomamentioning

confidence: 99%

“…In vitro study further demonstrated T cell activation following HSPimmunization, which initiated the production of inflammatory cytokine and FasL, resulting in RGC apoptosis. Recently, using mice deficient in CD4 + αβ T cells, it was reported that CD4 + T cells play a crucial role in propagating RGC degeneration, particularly during the prolonged period of progressive neural damage, in glaucoma (30). Uncovering the association between T cell-mediated autoimmunity and progressive neuron loss in glaucoma may allow the development of novel therapeutic interventions that eventually offer a cure for the disease.…”

Section: Involvement Of T Cells In Glaucomamentioning

confidence: 99%

“…Adaptive immune responses are elicited by specific antigen stimulation, and HSPs have been identified as pathogenic autoantigens which evoke T cell responses in glaucoma (30). The stress response is a highly conserved mechanism of cellular responses to a wide variety of physiological challenges (37).…”

Section: Hsps As Pathogenic Autoantigens In T Cell-mediated Glaucomatmentioning

confidence: 99%

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Adaptive Immunity: New Aspects of Pathogenesis Underlying Neurodegeneration in Glaucoma and Optic Neuropathy

2020

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Glaucoma is a globally unmet medical challenge and the most prevalent neurodegenerative disease, which permanently damages the optic nerve and retinal ganglion cells (RGCs), leading to irreversible blindness. Present therapies target solely at lowering intraocular ocular pressure (IOP), a major risk factor of the disease; however, elevated IOP is neither necessary nor sufficient to cause glaucoma. Glaucomatous RGC and nerve fiber loss also occur in individuals with normal IOP. Recent studies have provided evidence indicating a link between elevated IOP and T cell-mediated autoimmune responses, particularly that are specific to heat shock proteins (HSPs), underlying the pathogenesis of neurodegeneration in glaucoma. Reactive glial responses and low-grade inflammation may initially represent an adaptive reaction of the retina to primary stress stimuli; whereas, sustained and excessive glial reactions lead to expanded immune responses, including adaptive immunity, that contribute to progressive neural damage in glaucoma. Emerging data suggest a similar mechanism in play in causing neurodegeneration of other forms of optic neuropathy, such as that resulted from acute ischemia and traumatic injuries. These studies may lead to the paradigm shift and offer a new basis for the development of novel mechanism-based diagnosis, therapy, and preventive interventions for glaucoma. As HSPs are induced under various conditions of neural stress and damage in the brain and spinal cord, these findings may have broader implications for our elucidating of the etiology of other neurodegenerative disorders in the central nervous system.

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Novel inflammatory cytokines (IL-36, 37, 38) in the aqueous humor from patients with chronic primary angle closure glaucoma

Zhang

Song

Chen

et al. 2019

International Immunopharmacology

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Author Correction: Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma

Abstract: The originally published version of this Article contained an error in Figure 4. The bar chart in panel f was inadvertently replaced with a duplicate of the bar chart in panel e. This error has now corrected in both the PDF and HTML versions of the Article.

Cited by 10 publications

References 0 publications

Characteristic Cytokine Profiles of Aqueous Humor in Glaucoma Secondary to Sturge-Weber Syndrome

Characteristic Cytokine Profiles of Aqueous Humor in Glaucoma Secondary to Sturge-Weber Syndrome

Adaptive Immunity: New Aspects of Pathogenesis Underlying Neurodegeneration in Glaucoma and Optic Neuropathy

Novel inflammatory cytokines (IL-36, 37, 38) in the aqueous humor from patients with chronic primary angle closure glaucoma

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