Author Correction: Combining streptozotocin and unilateral nephrectomy is an effective method for inducing experimental diabetic nephropathy in the ‘resistant’ C57Bl/6J mouse strain

Abstract

Figure 1. Albumin and glucose excretion in urine. (A) Albumin excretion in 24 hours urine was measured by ELISA. CSU mice showed increased urinary albumin levels. (B) Glucose was measured by an enzymatic glucose kit. CSU mice showed a large increase in urinary glucose compared to C, and WS and WSU mice had increased urinary glucose excretion compared to WU mice. Data are represented as mean ± SEM. *p < 0.05.

Translation Animal Models of Diabetic Kidney Disease: Biochemical and Histological Phenotypes, Advantages and Limitations

“…Hyperglycemia, albuminuria, and early glomerular pathological changes such as glomerular hypertrophy, GBM thickening, mesangial matrix expansion and mild glomerulosclerosis can be observed in UNx + STZ treated mice and rats. 38–43 Furthermore, tubular atrophy, brush border loss, tubular dilatation and tubulointerstitial fibrosis develop in B6 mice at 12th week after the treatment of UNx and multiple low-dose STZ. 38 These tubular damages are considered to be caused by glucose toxicity, while they are not evident or present under chemical induction alone.…”

“… 38–43 Furthermore, tubular atrophy, brush border loss, tubular dilatation and tubulointerstitial fibrosis develop in B6 mice at 12th week after the treatment of UNx and multiple low-dose STZ. 38 These tubular damages are considered to be caused by glucose toxicity, while they are not evident or present under chemical induction alone.…”