Author Correction: Clearance of HIV infection by selective elimination of host cells capable of producing HIV

Li, Min; Bauch, Tonya; Graviss, Edward A.; Arduino, Roberto C.; Kimata, Jason T.; Chen, Min; Wang, Jin

doi:10.1038/s41467-020-20218-9

Cited by 6 publications

(2 citation statements)

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“…In a seminal study, a mixture of bNAbs in concert with three latency-reversing agents, i.e., an HDAC inhibitor, a BET protein inhibitor, and a T-cell inhibitory pathway blocker, succeeded in curing HIV in the majority of hu NRG mice [90]. Another very intriguing approach, which is known as the "selective elimination of host cells capable of producing HIV" (SECH), was described using hu NSG-SGM3 mice and achieved the permanent clearance of HIV in >50% of mice [113]. SECH is based on administering compounds to trigger viral reactivation and compounds to induce apoptosis and block autophagy.…”

Section: Ad: Exploring Experimental Strategies To Eradicate Dormant Hivmentioning

confidence: 99%

“…SECH is based on administering compounds to trigger viral reactivation and compounds to induce apoptosis and block autophagy. The idea behind SECH is that the apoptosis-inducing proteins take over exclusively in HIV-infected cells [113]. When SECH was applied subsequently to effective cART, complete clearance of HIV infection was observed.…”

Section: Ad: Exploring Experimental Strategies To Eradicate Dormant Hivmentioning

confidence: 99%

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The Humanized Mouse Model: What Added Value Does It Offer for HIV Research?

et al. 2023

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In the early 2000s, novel humanized mouse models based on the transplantation of human hematopoietic stem and progenitor cells (HSPCs) into immunocompromised mice were introduced (hu mice). The human HSPCs gave rise to a lymphoid system of human origin. The HIV research community has greatly benefitted from these hu mice. Since human immunodeficiency virus (HIV) type 1 infection results in a high-titer disseminated HIV infection, hu mice have been of great value for all types of HIV research from pathogenesis to novel therapies. Since the first description of this new generation of hu mice, great efforts have been expended to improve humanization by creating other immunodeficient mouse models or supplementing mice with human transgenes to improve human engraftment. Many labs have their own customized hu mouse models, making comparisons quite difficult. Here, we discuss the different hu mouse models in the context of specific research questions in order to define which characteristics should be considered when determining which hu mouse model is appropriate for the question posed. We strongly believe that researchers must first define their research question and then determine whether a hu mouse model exists, allowing the research question to be studied.

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Section: Ad: Exploring Experimental Strategies To Eradicate Dormant Hivmentioning

confidence: 99%

Section: Ad: Exploring Experimental Strategies To Eradicate Dormant Hivmentioning

confidence: 99%

The Humanized Mouse Model: What Added Value Does It Offer for HIV Research?

et al. 2023

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Modulation of the autophagic pathway inhibits HIV-1 infection in human lymphoid tissue cultured ex vivo

Pedreño-López

García

Guerrero

et al. 2022

Sci Rep

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A complex link exists between HIV-1 and autophagy, and discordant results have been reported in different in vitro models regarding the way HIV and autophagy modulate each other. Despite this, there is very limited knowledge about the interplay between HIV and autophagy in vivo in lymphoid tissue, due in part by the lack of cell models that recapitulate the in vivo setting. Here, we evaluate the interrelationship between HIV and autophagy using human ex vivo lymphoid tissue cultures as an HIV infection model. Our results showed that human lymphoid aggregated cultures (HLACs) from tonsillar tissue displayed fully functional autophagic activity. In this system, HIV infection resulted in an increase in autophagy. Notably, we observed that both, autophagy-enhancing (rapamycin) or blocking drugs (3-methyladenine, chloroquine and bafilomycin), were able to decrease HIV-DNA levels and HIV replication. Therefore, efficient HIV-1 replication requires a fine-tuned level of autophagy, so modifications of this balance will have a negative impact on its replication. Therefore, targeting the autophagic pathway could be a new therapeutic approach to be explored to treat HIV-1 infection. Ex vivo cultures of human lymphoid tissue are a suitable model to obtain further insights into HIV and its intricate relationship with autophagy.

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Selective elimination of host cells harboring replication-competent human immunodeficiency virus reservoirs: a promising therapeutic strategy for HIV cure

Zaongo¹,

Ma²,

Song³

et al. 2021

Chinese Medical Journal

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Many seminal advances have been made in human immunodeficiency virus (HIV)/AIDS research over the past four decades. Treatment strategies, such as gene therapy and immunotherapy, are yielding promising results to effectively control HIV infection. Despite this, a cure for HIV/AIDS is not envisioned in the near future. A recently published academic study has raised awareness regarding a promising alternative therapeutic option for HIV/AIDS, referred to as “selective elimination of host cells capable of producing HIV” (SECH). Similar to the “shock and kill strategy,” the SECH approach requires the simultaneous administration of drugs targeting key mechanisms in specific cells to efficiently eliminate HIV replication-competent cellular reservoirs. Herein, we comprehensively review the specific mechanisms targeted by the SECH strategy. Briefly, the suggested cocktail of drugs should contain (i) latency reversal agents to promote the latency reversal process in replication-competent reservoir cells, (ii) pro-apoptotic and anti-autophagy drugs to induce death of infected cells through various pathways, and finally (iii) drugs that eliminate new cycles of infection by prevention of HIV attachment to host cells, and by HIV integrase inhibitor drugs. Finally, we discuss three major challenges that are likely to restrict the application of the SECH strategy in HIV/AIDS patients.

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Author Correction: Clearance of HIV infection by selective elimination of host cells capable of producing HIV

Abstract: A Correction to this paper has been published: https://doi.org/10.1038/s41467-020-20218-9

Cited by 6 publications

References 0 publications

The Humanized Mouse Model: What Added Value Does It Offer for HIV Research?

The Humanized Mouse Model: What Added Value Does It Offer for HIV Research?

Modulation of the autophagic pathway inhibits HIV-1 infection in human lymphoid tissue cultured ex vivo

Selective elimination of host cells harboring replication-competent human immunodeficiency virus reservoirs: a promising therapeutic strategy for HIV cure

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