Author Correction: Chronic IL-1β-induced inflammation regulates epithelial-to-mesenchymal transition memory phenotypes via epigenetic modifications in non-small cell lung cancer

Li, Rui; Ong, Stephanie L.; Tran, Linh M.; Jing, Zhe; Liu, Bin; Park, Stacy J.; Huang, Zi Ling; Walser, Tonya C.; Heinrich, Eileen L.; Lee, Gina; Salehi‐Rad, Ramin; Crosson, William P.; Pagano, Paul C.; Paul, Manash K.; Xu, Shili; Herschman, Harvey R.; Krysan, Kostyantyn; Dubinett, Steven M.

doi:10.1038/s41598-020-61341-3

Cited by 14 publications

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“…signaling by activating multiple pathways (63)(64)(65)(66). Recently IL-1b has been shown to promote EMT via epigenetic modifications in non-small cell lung cancer (67).…”

Section: Cytokines In Cancer Metastasis and Invasionmentioning

confidence: 99%

Tumor-Induced Inflammatory Cytokines and the Emerging Diagnostic Devices for Cancer Detection and Prognosis

et al. 2021

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Chronic inflammation generated by the tumor microenvironment is known to drive cancer initiation, proliferation, progression, metastasis, and therapeutic resistance. The tumor microenvironment promotes the secretion of diverse cytokines, in different types and stages of cancers. These cytokines may inhibit tumor development but alternatively may contribute to chronic inflammation that supports tumor growth in both autocrine and paracrine manners and have been linked to poor cancer outcomes. Such distinct sets of cytokines from the tumor microenvironment can be detected in the circulation and are thus potentially useful as biomarkers to detect cancers, predict disease outcomes and manage therapeutic choices. Indeed, analyses of circulating cytokines in combination with cancer-specific biomarkers have been proposed to simplify and improve cancer detection and prognosis, especially from minimally-invasive liquid biopsies, such as blood. Additionally, the cytokine signaling signatures of the peripheral immune cells, even from patients with localized tumors, are recently found altered in cancer, and may also prove applicable as cancer biomarkers. Here we review cytokines induced by the tumor microenvironment, their roles in various stages of cancer development, and their potential use in diagnostics and prognostics. We further discuss the established and emerging diagnostic approaches that can be used to detect cancers from liquid biopsies, and additionally the technological advancement required for their use in clinical settings.

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“…signaling by activating multiple pathways (63)(64)(65)(66). Recently IL-1b has been shown to promote EMT via epigenetic modifications in non-small cell lung cancer (67).…”

Section: Cytokines In Cancer Metastasis and Invasionmentioning

confidence: 99%

Tumor-Induced Inflammatory Cytokines and the Emerging Diagnostic Devices for Cancer Detection and Prognosis

et al. 2021

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“…28 TLR4 was pivotal promoter of inflammation which related NF-kB and C3 signaling, and then released TNF-α and ILs, which can induce apoptosis of osteosarcoma cells. 10,11,31,32 However, whether the role of COLEC12 for inflammation in osteosarcoma is regulated by TLR4…”

Section: F I G U R Ementioning

confidence: 99%

“…[7][8][9] TNF-α and ILs are pro-inflammatory cytokines produced by lymphocytes and macrophages, which can induce apoptosis of tumor cells and are associated with the progression of several types of tumors, including OS. 10,11 In addition, TNF-α and ILs are transcriptionally controlled by NF-kB and C3 signaling 12,13 ; therefore, searching the upstream key factors to regulate the inflammatory response may be a vital step in the treatment of osteosarcoma.…”

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confidence: 99%

COLEC12 regulates apoptosis of osteosarcoma through Toll‐like receptor 4–activated inflammation

Deng

et al. 2020

Clinical Laboratory Analysis

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“…A signal for modulation of interferon alpha and gamma signalling may reflect a reduction in the non-Type 2 component of the inflammatory CRS response ( 14 ), where persistently high levels of interferon exert detrimental effects by impairing strength and coordination of subsequent immune responses and hampering cellular function ( 15 ). These changes can contribute to the development of epithelial to mesenchymal transition characteristic of CRS ( 16 ). Moreover, high levels of Type 1 inflammatory mediators is associated with a functional defect in epithelial repair in respiratory epithelial cells ( 17 ).…”

Section: Discussionmentioning

confidence: 99%

Response to intranasal Lactococcus lactis W136 probiotic supplementation in refractory CRS is associated with modulation of non-type 2 inflammation and epithelial regeneration

et al. 2023

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JustificationWe have previously documented that in individuals with chronic rhinosinusitis (CRS) refractory to surgery, intranasal application of live Lactococcus lactis W136, a probiotic bacterium, improves sinus-specific symptoms, SNOT-22, and mucosal aspect on endoscopy, accompanied by a reduction in sinus pathogens and an increase in protective bacteria. The present work explores the molecular mechanisms underpinning these observations using transcriptomics of the sinus mucosa.MethodEpithelial brushings collected prospectively as a sub-study of the L. lactis W136 clinical trial were used to probe epithelial responses to microbiome supplementation using a hypothesis-free bioinformatic analysis of gene expression analysis. Samples from twenty-four patients with CRS refractory to medical and surgical management were prospectively collected during a clinical trial assessing the effect of 14 days of BID nasal irrigation with 1.2 billion CFU of live L. lactis W136 probiotic bacteria (CRSwNP = 17, CRSsNP = 7). Endoscopically guided sinus brushings were collected as part of the initial study, with brushings performed immediately before and after treatment. Following RNA extraction, samples were assessed using the Illumina HumanHT-12 V4 BeadChip. Differential gene expression was calculated, and pathway enrichment analysis was performed to identify potentially implicated processes.ResultsDifferentially identified transcripts and pathways were assessed for the overall population and the clinical phenotypes of CRSwNP and CRSsNP. Patterns of response to treatment were similar across all groups, implicating pathways for the regulation of immunity and epithelial cell regulation. These resemble the patterns of improvement observed following successful treatment with endoscopic sinus surgery or azithromycin.ConclusionGene expression profiling following the application of live bacteria to the diseased sinus epithelium highlights the implication of multiple components of the inflammation-microbiome-epithelial barrier axis implicated in CRS. These effects appear to involve both epithelial restoration and modulation of innate and adaptive immunity, supporting the potential interest of targeting the sinus epithelium and the microbiome as potential CRS therapies.

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Author Correction: Chronic IL-1β-induced inflammation regulates epithelial-to-mesenchymal transition memory phenotypes via epigenetic modifications in non-small cell lung cancer

Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Cited by 14 publications

References 0 publications

Tumor-Induced Inflammatory Cytokines and the Emerging Diagnostic Devices for Cancer Detection and Prognosis

Tumor-Induced Inflammatory Cytokines and the Emerging Diagnostic Devices for Cancer Detection and Prognosis

COLEC12 regulates apoptosis of osteosarcoma through Toll‐like receptor 4–activated inflammation

Response to intranasal Lactococcus lactis W136 probiotic supplementation in refractory CRS is associated with modulation of non-type 2 inflammation and epithelial regeneration

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