Author Correction: Bacterial communities associated with the surface of fresh sweet pepper (Capsicum annuum) and their potential as biocontrol

Mamphogoro, Tshifhiwa Paris; Maboko, Martin Makgose; Babalola, Olubukola Oluranti; Aiyegoro, Olayinka Ayobami

doi:10.1038/s41598-021-82923-9

Cited by 3 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…By the BugBase analysis, we discovered that the secukinumab treatment group exhibited more significant abundance in containing mobile elements phenotype, forming biofilms phenotype, and gram-positive phenotype and less abundance in gram-negative phenotype and potentially pathogenic phenotype. Biofilms are described as a complex structure of the microbiome that can grow on many different surfaces, the formation of which can promote pathogenicity as well as the stability of bacterial communities, leading to stronger stress tolerance (Mamphogoro et al, 2021 ). Mobile genetic elements (MGEs) contribute to bacterial adaptation and evolution, which improve resistance to environmental change (Durrant et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Successful secukinumab therapy in plaque psoriasis is associated with altered gut microbiota and related functional changes

Du,

Yan,

Kong

et al. 2023

Front. Microbiol.

View full text Add to dashboard Cite

IntroductionThe role of gut microbiome dysbiosis in the pathogenesis of psoriasis has gained increasing attention in recent years. Secukinumab, targeting interleukin (IL)-17, has a promising efficacy in psoriasis treatment. However, it remains unclear the gut microbiota alteration and related functional changes caused by successful secukinumab therapy in psoriatic patients.MethodsIn our study, we compared the fecal microbiome profile between psoriatic patients after secukinumab successful treatment (AT) and the other two groups, psoriatic patients without therapy (BT) and healthy people (H), respectively, by using next-generation sequencing targeting 16S ribosomal RNA. Then, shotgun metagenomic sequencing was first used to characterize bacterial gut microbial communities and related functional changes in the AT group.ResultsWe found that the diversity and structure of the microbial community in the AT group were significantly changed compared to those in the BT group and the H group. The AT group showed a microbiota profile characterized by increased proportions of the phylum Firmicute, families Ruminococcaceae, and a reduction in the phylum Bacteroidota (elevated F/B ratio). To detect functional alteration, we discovered that secukinumab treatment may construct a more stable homeostasis of the gut microbiome with functional alteration. There were different KEGG pathways, such as the downregulated cardiovascular diseases pathway and the upregulated infectious diseases in the AT group. By metagenomic analysis, the metabolic functional pathway was changed after secukinumab therapy.DiscussionIt seems that gut microbiota investigation during biologic drug treatment is useful for predicting the efficacy and risks of drug treatment in disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Successful secukinumab therapy in plaque psoriasis is associated with altered gut microbiota and related functional changes

Du,

Yan,

Kong

et al. 2023

Front. Microbiol.

View full text Add to dashboard Cite

show abstract

“…By BugBase analysis, we discovered that secukinumab treatment group exhibited more signi cant abundance in contains mobile elements phenotype, form bio lms phenotype, gram positive phenotype, and less abundance in gram negative phenotype and potentially pathogenic phenotype. Bio lms are described as a complex structure of microbiome that can grow on many different surfaces, the formation of which can promote pathogenicity as well as the stability of bacterial communities leading to stronger stress tolerance [29]. Mobile genetic elements (MGEs) contribute to bacterial adaptation and evolution which make a better resistance to environment change [30].…”

Section: Discussionmentioning

confidence: 99%

Successful treatment of psoriasis with secukinumab constructed a new homeostasis of gut microbiome

Yan

Kong

et al. 2022

Preprint

View full text Add to dashboard Cite

Background: Secukinumab (an interleukin (IL)-17 inhibitor) has been reported to be able to alter gut microbiome composition in psoriatic patients. However, it still remains unclear the gut microbiota alteration and related functional changes caused by successful secukinumab therapy in psoriatic patients. In this study, fecal samples from healthy people as comtrol (H; n=35), psoriatic patients without therapy (BT; n=32) and patients after 5-month successful secukinumab treatment (AT; n=11) were collected., Then gut microbiomes were investigated using next-generation sequencing targeting 16S ribosomal RNA. Results: Successful secukinumab therapy caused a significantly elevated microbiota richness and biodiversity, as well as an alteration in the gut microbiota composition than psoriasis without therapy and healthy control. The psoriatic patients after secukinumab successful therapy showed a microbiota profile characterized by increased proportions of the phylum Firmicute, families Comamonadaceae and Erwiniaceae, and a reduction in the phylum Bacteroidota, compared to the other two groups. Besides, we discovered that secukinumab treatment group exhibited more significant abundance in contains mobile elements phenotype, form biofilms phenotype, gram positive phenotype, and less abundance in gram negative phenotype and potentially pathogenic phenotype by BugBase. Functional analysis showed the different COG pathways and KEGG pathways such as downregulated cardiovascular diseases pathway and upregulated infectious diseases between secukinumab therapy group and the other two groups.Conclusions: Secukinumab therapy enhanced the diversity of gut microbiota and altered the composition of the gut microbiome, which actually may construct a more stable homeostasis of gut microbiome with less potentially pathogenicity.

show abstract

Insights into the microbiological mechanism of antibiotic removal in an aerobic-microaerobic process treating manure-free piggery wastewater

Tian,

Li,

Liu

et al. 2024

Chemical Engineering Journal

View full text Add to dashboard Cite

Author Correction: Bacterial communities associated with the surface of fresh sweet pepper (Capsicum annuum) and their potential as biocontrol

Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Cited by 3 publications

References 0 publications

Successful secukinumab therapy in plaque psoriasis is associated with altered gut microbiota and related functional changes

Successful secukinumab therapy in plaque psoriasis is associated with altered gut microbiota and related functional changes

Successful treatment of psoriasis with secukinumab constructed a new homeostasis of gut microbiome

Insights into the microbiological mechanism of antibiotic removal in an aerobic-microaerobic process treating manure-free piggery wastewater

Contact Info

Product

Resources

About