Author Correction: Age-associated mitochondrial DNA mutations cause metabolic remodeling that contributes to accelerated intestinal tumorigenesis

Abstract

In the version of this article initially published, the Acknowledgements section lacked recognition of the Newcastle University Bioimaging Unit. The correct beginning of that section is as follows: "We thank T. Prolla (University of Wisconsin, Washington, USA) for donating the PolgA +/mut mice, and C. Alston for assistance in the analysis of mtDNA mutations. We thank staff in the Newcastle University Comparative Biology Centre for the animal husbandry, and the Newcastle University Bioimaging Unit for support and assistance with fluorescent imaging. " The error has been corrected in the HTML and PDF versions of the article.

Mitochondrial H2O2release does not directly cause genomic DNA damage

“…Iron release could also drive the Fenton reaction mediated • OH production and subsequent damage. Intramitochondrial ROS could also be different than H 2 O 2 release in the sense that it could potentially damage the mitochondrial genome, which also has been suggested to contribute to cancer development 39 . Using KillerRed to produce superoxide directly in mitochondria instead of H 2 O 2 could be a complementary approach to DAAO 40 .…”