Author Correction: A novel atypical sperm centriole is functional during human fertilization

Abstract

In the original version of this Article, the affiliation details for Jadranka Loncarek and Vito Mennella were incorrectly given as ‘Cell Biology Program, The Hospital for Sick Children, Department of Biochemistry, University of Toronto, 555 University Avenue, Toronto, ON, M5G 1X8, Canada’ and ‘Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute, 1050 Boyles Street, Frederick, MD, 21702, USA’, respectively. This has now been corrected in both the PDF and HTML versions of the Article.

Centriole-less pericentriolar material serves as a microtubule organizing center at the base of C. elegans sensory cilia

“…This structure is also competent to serve as an MTOC in mitotic extract suggesting conservation of the mechanisms described here. 33 Together, our studies reveal the innate ability of SPD-5 to recruit microtubule regulators which likely underlies the ability of the centrosome to function as an MTOC.…”

Separation and Loss of Centrioles From Primordidal Germ Cells To Mature Oocytes In The Mouse

“…The GFP CETN2 doublets identified here likely fall into the category of centrioles described as “advertisements,” “remnants”, “passenger” or “zombie” structures 61 – 64 ; i.e., vestigial, non-functional, and non-replicating centrioles. Perhaps centriole alterations mirror events seen in sperm distal centriole dissolution, where proximal centriole-like structures identified in the sperm of flies and humans lose their 3-dimensional 9-triplet microtubule structure, but retain PCM antigens and the ability to organize into functional MTOCs under the right conditions, such as after fertilization in the activated zygotic cytoplasm 64 , 65 . Indeed, the destruction of first one, and then the second, centriole in mouse sperm as these transit through the epididymis 25 underscores the complex behavior of centrosomes and centrioles in gametes even after they depart from the gonad.…”

Editorial: Sperm Differentiation and Spermatozoa Function: Mechanisms, Diagnostics, and Treatment

“…The centrioles are an evolutionarily-conserved sub-cellular organelle that evolved to have unique properties in sperm cells (Avidor-Reiss, 2018; Avidor-Reiss and Turner, 2019). Each human spermatozoon contains two remodeled centrioles that it contributes to the zygote (Fishman et al, 2018). Most previous investigations into the role of mammalian centrioles during fertilization were completed in murine models.…”