Author Correction: A GDSL lipase-like from Ipomoea batatas catalyzes efficient production of 3,5-diCQA when expressed in Pichia pastoris

Miguel, Sissi; Legrand, Guillaume; Duriot, Léonor; Delporte, Marianne; Menin, Barbara; Michel, Cindy; Olry, Alexandre; Châtaigné, Gabrielle; Salwiński, Aleksander; Bygdell, Joakim; Vercaigne, D.; Wingsle, Gunnar; Hilbert, Jean Louis; Bourgaud, Frédéric; Hehn, Alain; Gagneul, David

doi:10.1038/s42003-020-01488-x

Cited by 2 publications

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“…The major CQA derivates are mono (3-CQA, 4-CQA, and 5-CQA) and diCQAs [3,4-dicaffeoylquinic acids (3,4-diCQA), 3,5-dicaffeoylquinic acids (3,5-diCQA), and 4,5-dicaffeoylquinic acids (4,5-diCQA)] (Scheme ) and are found in various foods, including vegetables, fruits, coffee, tea, and so on. , As a member of CGAs, these isomers of diCQAs have anti-inflammatory, anti-hepatotoxic, and antioxidant effects. , Besides, diCQAs are being evaluated for the treatment of Alzheimer’s disease due to their neuroprotective potential, which has been extensively documented in the literature . Furthermore, diCQAs have been attributed to antiviral-cell fusion capabilities against a variety of human viruses, including the respiratory syncytial virus, adenovirus, herpes simplex 1 and 2, influenza A, human immunodeficiency virus, and Coxsackie B3. , DiCQAs are also reported as hypotensive compounds that work by regulating the angiotensin I-converting enzyme. In in vitro experiments, diCQAs show a high capability for radical scavenging .…”

Section: Introductionmentioning

confidence: 99%

“…7 Furthermore, diCQAs have been attributed to antiviral-cell fusion capabilities against a variety of human viruses, including the respiratory syncytial virus, adenovirus, herpes simplex 1 and 2, influenza A, human immunodeficiency virus, and Coxsackie B3. 8,9 DiCQAs are also reported as hypotensive compounds that work by regulating the angiotensin Iconverting enzyme. In in vitro experiments, diCQAs show a high capability for radical scavenging.…”

Section: ■ Introductionmentioning

confidence: 99%

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Multispectroscopic and Computational Investigations on the Binding Mechanism of Dicaffeoylquinic Acids with Ovalbumin

Manivel

Marimuthu

Sun

et al. 2022

J. Chem. Inf. Model.

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Recently, studies on the interactions between ovalbumin (OVA) and polyphenols have received a great deal of interest. This study explored the conformational changes and the interaction mechanism of the binding between OVA and chlorogenic acid (CGA) isomers such as 3,4-dicaffeoylquinic acids (3,4-diCQA), 4,5-dicaffeoylquinic acids (4,5-diCQA), and 3,5-dicaffeoylquinic acids (3,5-diCQA) using multispectroscopic and in silico analyses. The emission spectra show that the diCQAs caused strong quenching of OVA fluorescence under different temperatures through a static quenching mechanism with hydrogen bond (H-bond) and van der Waals (vdW) interactions. The values of binding constants (OVA–3,4-diCQA = 6.123 × 105, OVA–3,5-diCQA = 2.485 × 105, OVA–4,5-diCQA = 4.698 × 105 dm3 mol–1 at 298 K) suggested that diCQAs had a strong binding affinity toward OVA, among which OVA–3,4-diCQA exhibits higher binding constant. The results of UV–vis absorption and synchronous fluorescence indicated that the binding of all three diCQAs to OVA induced conformational and micro-environmental changes in the protein. The findings of molecular modeling further validate the significant role of vdW force and H-bond interactions in ensuring the stable binding of OVA–diCQA complexes. Temperature-dependent molecular dynamics simulation studies allow estimation of the individual components that contribute to the total bound free energy value, which allows evaluation of the nature of the interactions involved. This research can provide information for future investigations on food proteins’ physicochemical stability and CGA bioavailability in vitro or in vivo.

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Section: Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Multispectroscopic and Computational Investigations on the Binding Mechanism of Dicaffeoylquinic Acids with Ovalbumin

Manivel

Marimuthu

Sun

et al. 2022

J. Chem. Inf. Model.

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“…3,5-diCQA has high free radical scavenging activity ( Bernard et al, 2020 ). Phenolic compounds are beneficial to human health, especially their anti-inflammatory and antioxidant properties ( Miguel et al, 2020 ). Plant polyphenols help the skin resist the damage caused by sunlight ( Perez-Sanchez et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Plant-Derived Compounds as Promising Therapeutics for Vitiligo

Pang

et al. 2021

Front. Pharmacol.

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Vitiligo is the most common depigmenting disorder characterized by white patches in the skin. The pathogenetic origin of vitiligo revolves around autoimmune destruction of melanocytes in which, for instance, oxidative stress is responsible for melanocyte molecular, organelle dysfunction and melanocyte specific antigen exposure as well as melanocyte cell death and thus serves as an important contributor for vitiligo progression. In recent years, natural products have shown a wide range of pharmacological bioactivities against many skin diseases, and this review focuses on the effects and mechanisms of natural compounds against vitiligo models. It is showed that some natural compounds such as flavonoids, phenols, glycosides and coumarins have a protective role in melanocytes and thereby arrest the depigmentation, and, additionally, Nrf2/HO-1, MAPK, JAK/STAT, cAMP/PKA, and Wnt/β-catenin signaling pathways were reported to be implicated in these protective effects. This review discusses the great potential of plant derived natural products as anti-vitiligo agents, as well as the future directions to explore.

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Author Correction: A GDSL lipase-like from Ipomoea batatas catalyzes efficient production of 3,5-diCQA when expressed in Pichia pastoris

Abstract: A Correction to this paper has been published: https://doi.org/10.1038/s42003-020-01488-x

Cited by 2 publications

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Multispectroscopic and Computational Investigations on the Binding Mechanism of Dicaffeoylquinic Acids with Ovalbumin

Multispectroscopic and Computational Investigations on the Binding Mechanism of Dicaffeoylquinic Acids with Ovalbumin

Plant-Derived Compounds as Promising Therapeutics for Vitiligo

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