Australia Antigen in Acute and Chronic Liver Disease

Wright, Ralph; McCollum, Robert W.; Klatskin, Gerald

doi:10.1016/s0140-6736(69)92437-4

Cited by 229 publications

(60 citation statements)

References 16 publications

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“…Many groups of patients with chronic active hepatitis (CAH) have been studied from several viewpoints. They have been composed for the most part of hepatitis-B surface antigen (HBsAg) negative patients, especially in the Anglo-Saxon literature but less so on the European continent (Fox et al, 1969;Wright et al, 1969;Hadziyannis et al, 1970;Mistilis et al, 1970;Dubois et al, 1972;Wewalka, 1972;Henning et al, 1973). The present study analyses a group of patients with clinically almost inactive chronic hepatitis who have been followed-up for a very long period (up to 15 years) and almost all of whom have been treated with immunosuppressive drugs (prednisone and/or azathioprine).…”

mentioning

confidence: 99%

Long-term follow-up of chronic active hepatitis of moderate severity.

Groote¹,

Fevery²,

Lepoutre³

1978

Gut

115

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SUMMARY A group of patients with only moderately active chronic hepatitis has been studied. The follow-up was long (mean 87 months). All patients except one were treated with prednisone and/or azathioprine. Of the hepatitis B virus positive patients two-thirds developed cirrhosis between the second and fifth year of evolution, while in the hepatitis B negative group this occurred in less than one-third. The transition to cirrhosis was clinically silent. The patients were all allowed to do their normal work except in the terminal stages of cirrhosis. Five patients died of causes related to the disease: three patients with cirrhosis and hepatocellular carcinoma, one with gallbladder carcinoma, and one from bleeding varices. The high incidence of tumour, especially liver-cell carcinoma, may be due to a cumulative effect of the presence of hepatitis B virus, cirrhotic transformation, and immunosuppression. The other patients are currently in apparently good health.

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mentioning

confidence: 99%

Long-term follow-up of chronic active hepatitis of moderate severity.

Groote¹,

Fevery²,

Lepoutre³

1978

Gut

115

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show abstract

“…The observations that certain cases of chronic hepatitis are associated with hepatotoxic medications (12) or HBV infection (26) and that HBSAg-positive and negative chronic hepatitis appear to differ in clinical and immunologic features (27)(28)(29)(30)(31)(32) chronic hepatitis. These criteria provided defined patient groups which are representative of a large proportion of cases of chronic hepatitis in the U.S.A. (33,34) and the majority of cases of primary biliary cirrhosis (35). Further characterization of the patient groups was provided by the results of serologic tests for antiHBc and anti-HB,.…”

Section: Discussionmentioning

confidence: 99%

In vitro cell-mediated cytotoxicity in primary biliary cirrhosis and chronic hepatitis. Dysfunction of spontaneous cell-mediated cytotoxicity in primary biliary cirrhosis.

Vierling¹,

Nelson²,

Strober³

et al. 1977

J. Clin. Invest.

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“…If persistence of HBV does play a role in the aetiology of PHC, two possible mechanisms may be considered. Failure to clear the virus after an attack of acute hepatitis is known in some cases to lead to chronic active hepatitis and cirrhosis (Wright, McCollum and Klatskin, 1969;Sherlock et at., 1970), and PHC not infrequently develops in livers which are cirrhotic (Berman, 1951;MacDonald, 1956;Lin, 1970). HBsAg has been found in association with PHC in the absence of cirrhosis so that, alternatively, the virus may be directly oncogenic.…”

Section: Methodsmentioning

confidence: 99%