Research on belief in conspiracy theories identified many predictors, but often failed to investigate them together. In the present study, we tested how the most important predictors of beliefs in conspiracy theories explain endorsing COVID-19 and non-COVID-19 conspiracy theories, and conspiracy mentality. Apart from these three measures of conspiratorial thinking, participants (N = 354) completed several measures of epistemic, existential, and social psychological motives, as well as cognitive processing variables. While many predictors had significant correlations, only three consistently explained conspiratorial beliefs when included in one model: higher spirituality (the most important predictor), higher narcissism, and lower analytical thinking. Compared to the other two conspiratorial measures, predictors less explained belief in COVID-19 conspiracy theories, but this depended on items’ content. We conclude that the same predictors apply to belief in both COVID and non-COVID conspiracies, and identify spirituality as an important, but previously overlooked contributor to such beliefs.