Aurora-A Regulation of Nuclear Factor-κB Signaling by Phosphorylation of IκBα

Abstract

The Aurora-A

Retracted: Overexpression of Aurora A by loss of CHFR gene expression increases the growth and survival of HTLV‐1‐infected T cells through enhanced NF‐κB activity

“…25 Recent studies have suggested that Aurora A activates NF-jB signaling pathway in some cancer cell lines. 26,27 In this study, we investigated the effects of Aurora A on the growth and survival of HTLV-1-infected T-cell lines and primary ATL cells, with a special focus on NF-jB signaling pathway.…”

MK615 inhibits pancreatic cancer cell growth by dual inhibition of Aurora A and B kinases

“…Aurora A binds the E2 ubiquitin ligase UBE2N, and UBE2N phosphorylates IκBα. Activated IκB translocates NF-κB from the cytoplasm to the nucleus, resulting in activation of the NF-κB complex [25] . MK615 inhibits the expression of Aurora A, resulting in inhibition of NF-κB activation [26][27][28] .…”

Mechanism of action of the Aurora kinase inhibitor CCT129202 and in vivo quantification of biological activity

“…Immunoblotting was assessed as previously described (23). For cell cycle analysis, cells were treated with inhibitors for 24 h in the absence or presence of amphidicolin (1 Ag/mL) or nocodazole (50 ng/mL) and harvested with 5 mmol/L EDTA-PBS, then fixed in 85% ice-cold ethanol overnight and stained with propidium iodide (Sigma), and analyzed on Beckman Coulter Cytomics FC500.…”

“…A polymorphism in the Aurora A gene has been identified that shows preferential amplification associated with increased aneuploidy in colon cancer (22). We have shown recently that Aurora A mediates phosphorylation of InBa that induces nuclear factor-nB activation, a novel function of Aurora A, that could potentially lead to carcinogenesis and drug resistance (23,24).…”