Auricular transcutaneous vagus nerve stimulation specifically enhances working memory maintenance – a system neurophysiological study

Konjusha, Anyla; Yu, Shijing; Mückschel, Moritz; Ziemssen, Tjalf; Colzato, Lorenza S.; Beste, Christian

doi:10.1016/j.brs.2023.01.821

Cited by 2 publications

(2 citation statements)

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“…Although imaging studies elucidating tVNS effects on AD are in the preliminary stages, some hypotheses have been formulated based on existing research. A randomized crossover trial involving a healthy population found that taVNS influenced working memory by modulating the alpha band activity of the EGCs, potentially mediated by the GABA system (Konjusha et al, 2023). Huang et al (2023) conducted a clinical study using fMRI and observed that repetitive taVNS could modulate functional connectivity within the CNS region of the vagal pathway and limbic system, including the bilateral hippocampus, postcentral gyrus, thalamus, and basal ganglia.…”

Section: Vns Can Re-orchestrate Brain Plasticity Optimally In Admentioning

confidence: 99%

Transcutaneous vagus nerve stimulation: a new strategy for Alzheimer’s disease intervention through the brain-gut-microbiota axis?

Yan,

Li,

Qian

et al. 2024

Front. Aging Neurosci.

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Transcutaneous vagus nerve stimulation (tVNS) is an emerging non-invasive technique designed to stimulate branches of the vagus nerve distributed over the body surface. Studies suggest a correlation between the brain-gut-microbiota (BGM) axis and the pathogenesis of Alzheimer’s disease (AD). The BGM axis represents a complex bidirectional communication system, with the vagus nerve being a crucial component. Therefore, non-invasive electrical stimulation of the vagus nerve might have the potential to modify—most of the time probably in a non-physiological way—the signal transmission within the BGM axis, potentially influencing the progression or symptoms of AD. This review explores the interaction between percutaneous vagus nerve stimulation and the BGM axis, emphasizing its potential effects on AD. It examines various aspects, such as specific brain regions, gut microbiota composition, maintenance of intestinal environmental homeostasis, inflammatory responses, brain plasticity, and hypothalamic–pituitary–adrenal (HPA) axis regulation. The review suggests that tVNS could serve as an effective strategy to modulate the BGM axis and potentially intervene in the progression or treatment of Alzheimer’s disease in the future.

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Section: Vns Can Re-orchestrate Brain Plasticity Optimally In Admentioning

confidence: 99%

Transcutaneous vagus nerve stimulation: a new strategy for Alzheimer’s disease intervention through the brain-gut-microbiota axis?

Yan,

Li,

Qian

et al. 2024

Front. Aging Neurosci.

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“…It is also involved in conflict resolution with enhanced performance under tVNS compared to sham (Fischer et al, 2018). NE also plays a role in memory functions via induction of longterm potentiation in the hippocampus (Hopkins and Johnston, 1988;O'Dell et al, 2015), and several studies have shown improved memory and working memory functions following tVNS (Jacobs et al, 2015;Konjusha et al, 2023). Recent work has shown that tVNS led to improved emotion recognition probably through the release of NE in the hippocampus and the hippocampus's role in social-emotional memory processing (Colzato et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Transcutaneous Vagus Nerve Stimulation (tVNS) applications in cognitive aging: a review and commentary

Naparstek

Yeh

Mills-Finnerty

2023

Front. Aging Neurosci.

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Differentiating healthy from pathological aging trajectories is extremely timely, as the global population faces an inversion where older adults will soon outnumber younger 5:1. Many cognitive functions (e.g., memory, executive functions, and processing speed) decline with age, a process that can begin as early as midlife, and which predicts subsequent diagnosis with dementia. Although dementia is a devastating and costly diagnosis, there remains limited evidence for medications, therapies, and devices that improve cognition or attenuate the transition into dementia. There is an urgent need to intervene early in neurodegenerative processes leading to dementia (e.g., depression and mild cognitive impairment). In this targeted review and commentary, we highlight transcutaneous Vagus Nerve Stimulation (tVNS) as a neurostimulation method with unique opportunities for applications in diseases of aging, reviewing recent literature, feasibility of use with remote data collection methods/telehealth, as well as limitations and conflicts in the literature. In particular, small sample sizes, uneven age distributions of participants, lack of standardized protocols, and oversampling of non-representative groups (e.g., older adults with no comorbid diagnoses) limit our understanding of the potential of this method. We offer recommendations for how to improve representativeness, statistical power, and generalizability of tVNS research by integrating remote data collection techniques.

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Auricular transcutaneous vagus nerve stimulation specifically enhances working memory maintenance – a system neurophysiological study

Cited by 2 publications

References 0 publications

Transcutaneous vagus nerve stimulation: a new strategy for Alzheimer’s disease intervention through the brain-gut-microbiota axis?

Transcutaneous vagus nerve stimulation: a new strategy for Alzheimer’s disease intervention through the brain-gut-microbiota axis?

Transcutaneous Vagus Nerve Stimulation (tVNS) applications in cognitive aging: a review and commentary

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