Aureomycin in the Treatment of Yaws and Tropical Ulcer in Africa

Ampofo, O; Findlay, G. M.

doi:10.1038/165398b0

Cited by 23 publications

(5 citation statements)

References 3 publications

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“…like a charm in drying up the ulcers and fre eln/: them from bacterial infection (Findlay et ~h' 1944). The same results can be obtained Wit , aureomycin by mouth, the pus disappearing together with the spirochzetcs and fusiforms in forty-eight hours (Ampofo and Findlay, 1950). Noma or cancrum oris can also be cured by penicillin injections or aureomycin by mouth.…”

Section: Bacterial Diseasessupporting

confidence: 65%

“…Penicillin given by injection has now begun to be of value in rapidly clearing up the lesions of primary and secondary yaws although it has little effect on the serological reactions (Findlay et al , 1944, Hill et al , 1946). Recently aurcomycin by mouth has been shown to be as effective as penicillin: its use avoids the necessity of giving injections (Ampofo and Findlay, 1950). Chloramphenicol is also effective in primary and secondary yaws.…”

Section: Bacterial Diseasesmentioning

confidence: 99%

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Chemotherapy in Tropical Africa

Findlay¹

1950

Int J Clinical Practice

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Section: Bacterial Diseasessupporting

confidence: 65%

Section: Bacterial Diseasesmentioning

confidence: 99%

Chemotherapy in Tropical Africa

Findlay¹

1950

Int J Clinical Practice

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“…Before 2012, no other agents had been evaluated against yaws in randomized controlled trials, but there are published observational data suggesting prolonged courses of oral penicillin or tetracyclines could be effective. 33 , 34 Erythromycin has also been recommended based on its efficacy in the treatment of venereal syphilis. These treatment options are of less relevance since the emergence of azithromycin as an effective treatment for yaws.…”

Section: Attenuated Diseasementioning

confidence: 99%

Yaws

Marks

Mitjà

Solomon

et al. 2014

British Medical Bulletin

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IntroductionYaws, caused by Treponema pallidum ssp. pertenue, is endemic in parts of West Africa, Southeast Asia and the Pacific. The WHO has launched a campaign based on mass treatment with azithromycin, to eradicate yaws by 2020.Sources of dataWe reviewed published data, surveillance data and data presented at yaws eradication meetings.Areas of agreementAzithromycin is now the preferred agent for treating yaws. Point-of-care tests have demonstrated their value in yaws.Areas of controversyThere is limited data from 76 countries, which previously reported yaws. Different doses of azithromycin are used in community mass treatment for yaws and trachoma.Growing pointsYaws eradication appears an achievable goal. The programme will require considerable support from partners across health and development sectors.Areas timely for developing researchStudies to complete baseline mapping, integrate diagnostic tests into surveillance and assess the impact of community mass treatment with azithromycin are ongoing.

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“…No other agents have been shown in randomized clinical trials to be effective in the treatment of endemic treponemal diseases, but there are reports of treatment success with treatment regimens based on oral penicillin and tetracycline derivatives, 14 , 54 whilst erythromycin has been recommended based on its efficacy in the treatment of syphilis.…”

Section: Treatmentmentioning

confidence: 99%

Endemic treponemal diseases

Marks

Solomon

Mabey

2014

Transactions of the Royal Society of Tropical Medicine and Hygiene

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The endemic treponemal diseases, consisting of yaws, bejel (endemic syphilis) and pinta, are non-venereal infections closely related to syphilis, and are recognized by WHO as neglected tropical diseases (NTDs). Despite previous worldwide eradication efforts the prevalence of yaws has rebounded in recent years and the disease is now a major public health problem in 14 countries. Adequate data on the epidemiology of bejel and pinta is lacking. Each disease is restricted to a specific ecological niche but all predominantly affect poor, rural communities. As with venereal syphilis, the clinical manifestations of the endemic treponemal diseases are variable and can be broken down in to early stage and late stage disease. Current diagnostic techniques are unable to distinguish the different causative species but newer molecular techniques are now making this possible. Penicillin has long been considered the mainstay of treatment for the endemic treponemal diseases but the recent discovery that azithromycin is effective in the treatment of yaws has renewed interest in these most neglected of the NTDs, and raised hopes that global eradication may finally be possible.

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Aureomycin in the Treatment of Yaws and Tropical Ulcer in Africa

Cited by 23 publications

References 3 publications

Chemotherapy in Tropical Africa

Chemotherapy in Tropical Africa

Yaws

Endemic treponemal diseases

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