Aurasız Migrenli Hastalarda Oksidatif Stres Parametreleri

Abstract

Migraine is a multifaceted neurological disease whose molecular mechanisms are not yet clearly defined. Oxidative stress is also believed to play a role in the pathogenesis of migraine. The purpose of this study was to evaluate serum paraoxonase (PON) and arylesterase (ARE) activities, thiols levels, ischemia-modified albumin (IMA), the total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) in patients with migraine without aura.Materials and Methods: 30 patients (5 males and 25 females) and 30 matched healthy controls (8 males and 22 females) were enrolled. Serum PON and ARE activities, thiols levels, IMA, TAS, TOS and OSI were determined by using the spectrophotometric method in the study groups. Statistical analysis was conducted using Mann-Whitney U test and independent samples t-test, and p <0.05 was considered as statistically significant.Results: PON and ARE levels were significantly lower in the migraine without aura group compared with the control group (p <0.05). Conclusion:Our results suggested that the PON and ARE levels might be associated with migraine without aura. In migraine patients, it is recommended that oxidative stress markers be investigated with a larger population and these parameters are taken into consideration.