Auraptene from Ferula microloba

Borisov, V. N.; Ban'kovskii, A. I.; Шейченко, В. И.; Kabanov, V. S.

doi:10.1007/bf00567874

Cited by 3 publications

(1 citation statement)

References 1 publication

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“…Following analytical HPLC and lowresolution LC-MS analysis of selected fractions, a total of five compounds were purified via semi-preparative HPLC from three major fractions. These five compounds were confirmed to be the previously reported coumarins auraptene 9, 6 ′ -dehydromarmin 5, geiparvarin 3, as well as the alkaloids N-(acetoxymethyl) flindersine 2 and flindersine 1, based on their NMR chemical shifts and molecular masses obtained via LC-MS which were all in accordance with the literature data [4,5,18,25].…”

Section: Isolation Of Compounds From the Leaves Of G Parviflorasupporting

confidence: 88%

Phytochemical Profiling Studies of Alkaloids and Coumarins from the Australian Plant Geijera parviflora Lindl. (Rutaceae) and Their Anthelmintic and Antimicrobial Assessment

Dugan,

Bell,

Brkljača

et al. 2024

Metabolites

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Phytochemical profiling followed by antimicrobial and anthelmintic activity evaluation of the Australian plant Geijera parviflora, known for its customary use in Indigenous Australian ceremonies and bush medicine, was performed. In the present study, seven previously reported compounds were isolated including auraptene, 6′-dehydromarmin, geiparvarin, marmin acetonide, flindersine, and two flindersine derivatives from the bark and leaves, together with a new compound, chlorogeiparvarin, formed as an artifact during the isolation procedure and isolated as a mixture with geiparvarin. Chemical profiling allowed for a qualitative and quantitative comparison of the compounds in the leaves, bark, flowers, and fruit of this plant. Subsequently, a subset of these compounds as well as crude extracts from the plant were evaluated for their antimicrobial and anthelmintic activities. Anthelmintic activity assays showed that two of the isolated compounds, auraptene and flindersine, as well as the dichloromethane and methanol crude extracts of G. parviflora, displayed significant activity against a parasitic nematode (Haemonchus contortus). This is the first report of the anthelmintic activity associated with these compounds and indicates the importance of such fundamental explorations for the discovery of bioactive phytochemicals for therapeutic application(s).

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Section: Isolation Of Compounds From the Leaves Of G Parviflorasupporting

confidence: 88%

Phytochemical Profiling Studies of Alkaloids and Coumarins from the Australian Plant Geijera parviflora Lindl. (Rutaceae) and Their Anthelmintic and Antimicrobial Assessment

Dugan,

Bell,

Brkljača

et al. 2024

Metabolites

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Terpenoid coumarins and macro- and microelement composition of three types of roots of plants of the Genus Ferula L.

Babekov,

Murzubraimov,

Abjaparova

et al. 2024

E3S Web of Conf.

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This article presents the morphological structure, classification of biologically active substances, and chemical composition of plants of the genus Ferula, growing in Kyrgyzstan. Plants of the genus Ferula have long been used in folk medicine, as they contain biologically active compounds. The variety of biological properties of substances found in different types of ferula has prompted researchers to more carefully study their chemical composition. To date, chemotaxonomic summaries have been compiled for all major families of higher plants, but insufficient knowledge of the chemical composition of plants in Kyrgyzstan has led to the fact that many plants growing in Kyrgyzstan are not included in world reports. Research into the dynamics of the accumulation of biologically active substances to determine the optimal timing of raw material procurement, when certain useful substances accumulate in them in maximum quantities, is also relevant. Systematic studies in recent years have shown that the healing properties of medicinal plants are determined, first of all, by the harmonious combination of the biologically active substances of various classes of natural compounds they contain. This article also provides the macro- and microelement composition of the three types of roots of plants of the genus Ferula of the Apiaceae family. The accumulation of macro- and microelements in plants depends on the type of soil, its physical properties and chemical state, the geographical location of the area, climatic conditions and the stage of plant vegetation.

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Inhibitory Effects of Extracts from Citrus unshiu Marc. Encapsulated in Hybrid Liposomes on the Growth of Tumor Cells in Vitro

Ueoka¹,

Komizu²,

Goto³

et al. 2011

KAGAKU KOGAKU RONBUNSHU

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Auraptene from Ferula microloba

Cited by 3 publications

References 1 publication

Phytochemical Profiling Studies of Alkaloids and Coumarins from the Australian Plant Geijera parviflora Lindl. (Rutaceae) and Their Anthelmintic and Antimicrobial Assessment

Phytochemical Profiling Studies of Alkaloids and Coumarins from the Australian Plant Geijera parviflora Lindl. (Rutaceae) and Their Anthelmintic and Antimicrobial Assessment

Terpenoid coumarins and macro- and microelement composition of three types of roots of plants of the Genus Ferula L.

Inhibitory Effects of Extracts from Citrus unshiu Marc. Encapsulated in Hybrid Liposomes on the Growth of Tumor Cells in Vitro

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