Aurantiomides A−C, Quinazoline Alkaloids from the Sponge-Derived Fungus Penicillium aurantiogriseum SP0-19

Xin, Zhi Hong; Fang, Yuchun; Du, Lin; Zhu, Tianjiao; Duan, Lin; Chen, Juan; Gu, Qianqun; Zhu, Weiming

doi:10.1021/np060516h

Cited by 86 publications

(46 citation statements)

References 7 publications

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“…For example, peak 39 (RT=8.7 min, C 18 H 20 N 4 O 3 ) in extract 10 displayed similar UV maxima, i.e., 225 and 300 nm to its hit, aurantiomide C, a cytotoxic Extract 9 (TBG2-1(GPY-2)) Extract 10 (TBG2-2(GPY-1)) quinazoline alkaloid from a marine sponge-derived Penicillium strain SP0-19 (Xin et al, 2007).…”

Section: To Be Continuedmentioning

confidence: 99%

Isolation and characterization of bioactive fungi from shark Carcharodon carcharias’ gill with biopharmaceutical prospects

Zhang

Han

Feng

et al. 2015

Chin. J. Ocean. Limnol.

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Until recently, little was known about the fungi found in shark gills and their biomedicinal potential. In this article, we described the isolation, bioactivity, diversity, and secondary metabolites of bioactive fungi from the gill of a shark ( Carcharodon carcharias ). A total of 115 isolates were obtained and grown in 12 culture media. Fifty-eight of these isolates demonstrated signifi cant activity in four antimicrobial, pesticidal, and cytotoxic bioassay models. Four randomly selected bioactive isolates inhibited human cancer cell proliferation during re-screening. These active isolates were segregated into 6 genera using the internal transcribed spacer-large subunit (ITS-LSU) rDNA-sequence BLAST comparison. Four genera, Penicillium , Aspergillus , Mucor , and Chaetomium were the dominant taxa. A phylogenic tree illustrated their intergenera and intragenera genetic diversity. HPLC-DAD-HRMS analysis and subsequent database searching revealed that nine representative strains produced diverse bioactive compound profi les. These results detail the broad range of bioactive fungi found in a shark's gills, revealing their biopharmaceutical potential. To the best of our knowledge, this is the fi rst study characterizing shark gill fungi and their bioactivity.

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Section: To Be Continuedmentioning

confidence: 99%

Isolation and characterization of bioactive fungi from shark Carcharodon carcharias’ gill with biopharmaceutical prospects

Zhang

Han

Feng

et al. 2015

Chin. J. Ocean. Limnol.

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“…Another Penicillium strain, P. aurantiogriseum SP0-19, was isolated from the marine sponge Mycale plumose and shown to produce two novel quinazoline alkaloids: aurantiomides 37 and 38 . Compound 37 exhibited moderate cytotoxic activities against tumor cell lines HL-60 and P388 with IC 50 values of 52 and 54 μg/mL, respectively, while 38 selectively inhibited BEL-7402 and P388 cell lines with IC 50 values of 62 and 48 μg/mL, respectively [24]. …”

Section: Alkaloidsmentioning

confidence: 99%

Cytotoxic Natural Products from Marine Sponge-Derived Microorganisms

2017

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A growing body of evidence indicates that marine sponge-derived microbes possess the potential ability to make prolific natural products with therapeutic effects. This review for the first time provides a comprehensive overview of new cytotoxic agents from these marine microbes over the last 62 years from 1955 to 2016, which are assorted into seven types: terpenes, alkaloids, peptides, aromatics, lactones, steroids, and miscellaneous compounds.

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“…Three quinazoline alkaloids, aurantiomides A, B, and C were isolated from Penicillium aurantiogriseum SP0-19 associated with sponge Mycale plumose among which aurantiomides B and C showed moderate cytotoxicities against HL-60, P388 and BEL-7402 and P388 cell lines, respectively (Xin et al, 2007).…”

Section: Marine Fungimentioning

confidence: 99%

“…5α,8α-epidioxy-23-methyl-(22E,24R)-ergosta-6,22-dien-3β-ol with cytotoxic activity was isolated from the fungus Penicillium stoloniferum QY2-10, associated with a sea squirt (Xin et al, 2007). Six new ergo sterols obtained from a marine Bugula spp.…”

Section: Marine Fungimentioning

confidence: 99%

Review on bioactive potential of marine microbes

Vasanthabharathi¹,

Jayalakshmi²

2013

Afr. J. Microbiol. Res.

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There is a need for new drugs especially novel antibiotics, anticancer compound, antibiotic against multi drug-resistant bacteria. The discovery and development of new drugs from marine microbes played a significant role over the last few decades. The world oceans comprise a rich diversity of microbial life with current estimates reaching over a million different species. Marine microbes are important from both ecological and biotechnological point of view. Marine microbial bioactive compounds have attracted increasing attention from microbiologists, taxonomists, ecologists, agronomists, chemists and evolutionary biologists.

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Aurantiomides A−C, Quinazoline Alkaloids from the Sponge-Derived Fungus Penicillium aurantiogriseum SP0-19

Cited by 86 publications

References 7 publications

Isolation and characterization of bioactive fungi from shark Carcharodon carcharias’ gill with biopharmaceutical prospects

Isolation and characterization of bioactive fungi from shark Carcharodon carcharias’ gill with biopharmaceutical prospects

Cytotoxic Natural Products from Marine Sponge-Derived Microorganisms

Review on bioactive potential of marine microbes

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