AuNPs@mesoSiO2 composites for SERS detection of DTNB molecule

Lin, Chun‐Cheng; Chang, Chia-Wen

doi:10.1016/j.bios.2013.07.065

Cited by 36 publications

(15 citation statements)

References 37 publications

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“…7 , the optimum enhancement of SERS signals could be reached using 142.8 μM gold nanoparticles in Au-FePt@SiO 2 -N. This might be due to the increasing gold concentration that could increase the surface area of the nanoparticles then provide the larger sites for bacteria entrapment thus increasing the Raman signal of S. aureus , and also it might be due to the development an appropriate hot spot effect for enhancement of Raman signal. This is in accordance with previously reported researches [ 2 , 38 ]. Raman signal of S. aureus slightly reduced at higher concentration of Au-FePt@SiO 2 -N (190.4–238 μM) which is similar with the result of detecting adenine in Fig.…”

Section: Resultssupporting

confidence: 94%

Core-shell of FePt@SiO2-Au magnetic nanoparticles for rapid SERS detection

et al. 2015

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In this study, multifunctional hybrid nanoparticles composed of iron platinum (FePt), silica (SiO2), and gold nanoparticles (AuNPs) had been developed for surface-enhanced Raman scattering (SERS) application. Core-shell structure of SiO2 and FePt nanoparticles (FePt@SiO2) was fabricated through sol-gel process and then immobilized gold nanoparticles onto the surface of FePt@SiO2, which displays huge Raman enhancement effect and magnetic separation capability. The resulting core-shell nanoparticles were subject to evaluation by transmission electron microscopy (TEM), Energy-dispersive X-ray spectroscopy (EDX), zeta potential measurement, and X-ray photoelectron spectroscopy (XPS). TEM observation revealed that the particle size of resultant nanoparticles displayed spherical structure with the size ~30 nm and further proved the successful immobilization of Au onto the surface of FePt@SiO2. Zeta potential measurement exhibited the successful reaction between FePt@SiO2 and AuNPs. The rapid SERS detection and identification of small biomolecules (adenine) and microorganisms (gram-positive bacteria, Staphylococcus aureus) was conducted through Raman spectroscopy. In summary, the novel core-shell magnetic nanoparticles could be anticipated to apply in the rapid magnetic separation under the external magnetic field due to the core of the FePt superparamagnetic nanoparticles and label-free SERS bio-sensing of biomolecules and bacteria.Electronic supplementary materialThe online version of this article (doi:10.1186/s11671-015-1111-0) contains supplementary material, which is available to authorized users.

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Section: Resultssupporting

confidence: 94%

Core-shell of FePt@SiO2-Au magnetic nanoparticles for rapid SERS detection

et al. 2015

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“…Our spatially confined, in situ growth method overcame these problems because the growth medium was CTAB-free and the Raman reporters were preconcentrated and evenly distributed in mSiO 2 in a threedimensional manner for generating SERS signals. 41 Moreover, the protection of the elastic mSiO 2 shell prevented the aggregation of the grown NPs even after multiple washing steps.…”

Section: Acs Applied Materials and Interfacesmentioning

confidence: 99%

“Elastic” Property of Mesoporous Silica Shell: For Dynamic Surface Enhanced Raman Scattering Ability Monitoring of Growing Noble Metal Nanostructures via a Simplified Spatially Confined Growth Method

Lin

Wang

Sun

et al. 2015

ACS Appl. Mater. Interfaces

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ABSTRACT:The Raman enhancing ability of noble metal nanoparticles (NPs) is an important factor for surface enhanced Raman scattering (SERS) substrate screening, which is generally evaluated by simply mixing as-prepared NPs with Raman reporters for Raman signal measurements. This method usually leads to incredible results because of the NP surface coverage nonuniformity and reporter-induced NP aggregation. Moreover, it cannot realize in situ, continuous SERS characterization. Herein, we proposed a dynamic SERS monitoring strategy for NPs with precisely tuned structures based on a simplified spatially confined NP growth method. Gold nanorod (AuNR) seed NPs were coated with a mesoporous silica (mSiO 2 ) shell. The permeability of mSiO 2 for both reactive species and Raman reporters rendered the silver overcoating reaction and SERS indication of NP growth. Additionally, the mSiO 2 coating ensured monodisperse NP growth in a Raman reporter-rich reaction system. Moreover, "elastic" features of mSiO 2 were observed for the first time, which is crucial for holding the growing NP without breakage. This feature makes the mSiO 2 coating adhere to metal NPs throughout the growing process, providing a stable Raman reporter distribution microenvironment near the NPs and ensuring that the substrate's SERS ability comparison is accurate. Three types of NPs, i.e., core−shell Au@AgNR@mSiO 2 , Au@AuNR@mSiO 2 , and yolk−shell Au@void@AuNR@mSiO 2 NPs, were synthesized via core−shell overgrowth and galvanic replacement methods, showing the versatility of the approach. The living cell SERS labeling ability of Au@AgNR@mSiO 2 -based tags was also demonstrated. This strategy addresses the problems of multiple batch NP preparation, aggregation, and surface adsorption differentiation, which is a breakthrough for the dynamic comparison of SERS ability of metal NPs with precisely tuned structures and optical properties.

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“…To improve the sensitivity of using colloidal solutions for SERS detection, several methods have been developed, including heat-induced SERS sensing, , solvent-induced hotspot, elasticity-induced stretchable membrane, , coffee ring formation, − and other methods. Among them, methods based on the coffee ring effect are simple in detection, while the sensitivity is acceptable caused by the strengthening of the hotspot effect.…”

Section: Introductionmentioning

confidence: 99%

Tunable Coffee Ring Formation on Polycarbonate Nanofiber Film for Sensitive SERS Detection of Phenylalanine in Urine

Yang

2019

ACS Omega

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A new method based on the coffee ring effect was developed for improving the sensitivity, simplicity, and robustness of surface-enhanced Raman scattering (SERS) in determining trace levels of analytes. In this method, a polyvinylpyrrolidone (PVP)-stabilized silver colloidal (AgC) solution was first prepared and mixed with a sample solution. Following deposition of the mixture solution on a solid substrate with a rough surface, a coffee ring was formed once the solvent had evaporated. The formation of a coffee ring not only concentrated the analyte but also reduced the space between silver nanoparticles (AgNPs) to strengthen the hotspot effect, thereby considerably improving SERS sensitivity. To strengthen the coffee ring effect further, the surface roughness of the solid support and PVP content of the AgC solution were investigated. The results indicated that an increase in surface roughness reduced the size of the coffee rings, whereas the addition of PVP not only stabilized the AgNPs but also improved the compactness of the coffee rings. When applying the proposed method to determine the phenylalanine (Phe) level in urine for rapid screening of the phenylketonuria disorder, strong chemical interference from uric acid (UA), which is a major component in urine, was observed. To minimize the interference from UA, ZnO powder was applied to the urine sample to adsorb UA prior to SERS detection. After cleaning by using ZnO, the SERS signals of Phe were revealed for quantitative purposes. Under the optimized conditions, both the sensitivity and reproducibility of SERS measurement considerably improved. Quantitative analyses revealed that the developed method is highly feasible for the rapid determination of Phe in real samples.

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AuNPs@mesoSiO2 composites for SERS detection of DTNB molecule

Cited by 36 publications

References 37 publications

Core-shell of FePt@SiO2-Au magnetic nanoparticles for rapid SERS detection

Core-shell of FePt@SiO2-Au magnetic nanoparticles for rapid SERS detection

“Elastic” Property of Mesoporous Silica Shell: For Dynamic Surface Enhanced Raman Scattering Ability Monitoring of Growing Noble Metal Nanostructures via a Simplified Spatially Confined Growth Method

Tunable Coffee Ring Formation on Polycarbonate Nanofiber Film for Sensitive SERS Detection of Phenylalanine in Urine

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