Aumento da expressão do MCP-1 coroidal e escleral em modelo experimental de hipercolesterolemia

Abstract

This study has revealed that the hypercholesterolemic diet in rabbits induces an increase in the MCP-1 expression in the choroid and sclera.

Increased intercellular adhesion molecule-1 immunoreactivity in the sclera-choroid complex in hypercholesterolemia experimental model

“…In a recent experimental study, our group demonstrated that a hypercholesterolemic diet increased MCP-1 expression in the sclera and choroid, suggesting that the changes in great vessels that induce atherosclerotic plaque formation might also occur in the sclera-choroid complex (16) . After observing an increase in chemotactic molecules such as MCP-1, adhesion molecules had to be assessed to verify the hypothesis that atherosclerosis and AMD have similar pathophysiological mechanisms (17)(18)(19) .…”