Aujeszky's disease

Re, Oliver

doi:10.1111/j.1751-0813.1989.tb13570.x

Cited by 4 publications

(2 citation statements)

References 7 publications

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“…It is a major viral disease manifested in swine by signs and lesions that vary among different age groups [1]. The disease is characterized by three overlapping syndromes that reflect lesions in the central nervous system, respiratory system or reproductive system [2]. Gene-deleted modified-live vaccines accompanied by the application of ELISA serologic tests have been widely used to the control and eradication of Pseudorabies (PR) in the past decades [3].…”

Section: Introductionmentioning

confidence: 99%

Construction of a triple gene-deleted Chinese Pseudorabies virus variant and its efficacy study as a vaccine candidate on suckling piglets

Zhang¹,

Guo²,

Jia³

et al. 2015

Vaccine

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Section: Introductionmentioning

confidence: 99%

Construction of a triple gene-deleted Chinese Pseudorabies virus variant and its efficacy study as a vaccine candidate on suckling piglets

Zhang¹,

Guo²,

Jia³

et al. 2015

Vaccine

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“…PRV is able to infect nearly all mammals, including ruminants, carnivores, and rodents, yet swine have been confirmed to be the natural hosts and reservoir of this virus [ 1 ]. In pigs, PRV infection may lead to nervous signs and death in newborn pigs, respiratory disorders in fattening pigs, and reproductive failure in sows and remain latently infected in the central nervous system such as trigeminal ganglions following clinical recovery [ 2 ]. In the past decade, PRV has been eradicated in US and some European countries through gene-deleted modified-live vaccines accompanied by the application of ELISA serologic tests [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Construction of a gE-Deleted Pseudorabies Virus and Its Efficacy to the New-Emerging Variant PRV Challenge in the Form of Killed Vaccine

Wang¹,

Xiao²,

Yang³

et al. 2015

BioMed Research International

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The new-emerging PRV variants plague the vaccinated pigs and caused huge economic loss to local pig industry in China since 2011. The current commercial PRV vaccines cannot provide complete protection as the new-emerging PRV variants are antigenically different from the classical viruses. It is urgent to develop more safe and effective PRV vaccines based on the current circulating field isolates. In this study, a gE gene-deleted PRV based on the PRV HN1201, a representative PRV variant, was generated and the efficacy was tested on 3-week-old pigs in the form of killed vaccine. After fatal PRV HN1201 challenge, all vaccinated pigs survived without showing any clinical symptoms, but all unvaccinated pigs exhibited pseudorabies-specific respiratory and neurological signs with 100% mortality rate within 6 days after infection. The vaccinated pigs developed high level of gB and neutralizing antibodies after vaccination which may correlate to the protection provided by vaccine. Therefore, this gE gene-deleted PRV could be a promising vaccine candidate for the control of currently epidemic pseudorabies in China.

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Generating Recombinant Pseudorabies Virus for Use as a Vaccine Platform

Tan¹,

Li²,

Tian

2017

Methods in Molecular Biology

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Pseudorabies virus (PRV) is a promising vaccine vector due to its distinctive features including many nonessential replication regions and a broad host range. Foreign genes of other viruses have been successfully inserted into and expressed in PRV and these recombinant viruses are very likely to induce humoral and/or cellular responses in immunized animals. This chapter offers an overview of methods for generating recombinant pseudorabies virus for use as a vaccine vector.

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Aujeszky's disease

Cited by 4 publications

References 7 publications

Construction of a triple gene-deleted Chinese Pseudorabies virus variant and its efficacy study as a vaccine candidate on suckling piglets

Construction of a triple gene-deleted Chinese Pseudorabies virus variant and its efficacy study as a vaccine candidate on suckling piglets

Construction of a gE-Deleted Pseudorabies Virus and Its Efficacy to the New-Emerging Variant PRV Challenge in the Form of Killed Vaccine

Generating Recombinant Pseudorabies Virus for Use as a Vaccine Platform

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