Augmenting the bioactivity of polyetheretherketone using a novel accelerated neutral atom beam technique

Ajami, Sara; Coathup, MJ; Khoury, Joseph T.; Blunn, Gordon

doi:10.1002/jbm.b.33681

Cited by 25 publications

(16 citation statements)

References 59 publications

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“…In continuation of previous studies, we have employed a relatively recent technology called Accelerated Neutral Atom Beam (ANAB) that can modify the surface of an implantable medical device to a shallow depth of no greater than 2–3 nm [ 16 , 17 ]. The ANAB technique, described earlier in detail [ 18 ], employs an intense directed beam of neutral gas atoms, which have average energies that can be controlled over a range from a few electron volts (eV) to over 100 eV per atom.…”

Section: Introductionmentioning

confidence: 99%

Surface bioactivation of PEEK by neutral atom beam technology

Khoury

Селезнева

Pestov

et al. 2019

Bioactive Materials

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Polyetheretherketone (PEEK) is an alternative to metallic implants and a material of choice in many applications, including orthopedic, spinal, trauma, and dental. While titanium (Ti) and Ti-alloys are widely used in many intraosseous implants due to its biocompatibility and ability to osseointegrate, negatives include stiffness which contributes to shear stress, radio-opacity, and Ti-sensitivity. Many surgeons prefer to use PEEK due to its biocompatibility, similar elasticity to bone, and radiolucency, however, due to its inert properties, it fails to fully integrate with bone. Accelerated Neutral Atom Beam (ANAB) technology has been successfully employed to demonstrate enhanced bioactivity of PEEK both in vitro and in vivo . In this study, we further characterize surfaces of PEEK modified by ANAB as well as elucidate attachment and genetic effects of dental pulp stem cells (DPSC) exposed to these surfaces. ANAB modification resulted in decreased contact angle at 72.9 ± 4.5° as compared to 92.4 ± 8.5° for control (p < 0.01) and a decreased average surface roughness, however with a nano-textured surface profile. ANAB treatment also increased the ability of DPSC attachment and proliferation with considerable genetic differences showing earlier progression towards osteogenic differentiation. This surface modification is achieved without adding a coating or changing the chemical composition of the PEEK material. Taken together, we show that ANAB processing of PEEK surface enhances the bioactivity of implantable medical devices without an additive or a coating.

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Section: Introductionmentioning

confidence: 99%

Surface bioactivation of PEEK by neutral atom beam technology

Khoury

Селезнева

Pestov

et al. 2019

Bioactive Materials

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“…By contrast, non-degradable polymer such as polyetheretherketone (PEEK) with high temperature durability, excellent radiation stability and high Young’s modulus has found clinical applications as trauma fixation devices and spinal cages [12,13]. However, PEEK is bio-inert and hydrophobic, and cannot osteo-integrate with adjacent bone tissues upon implantation [14]. The bioactivity of PEEK can be greatly enhanced either by depositing HA coating on its surface [15], or by incorporating inorganic HA whiskers [16] and mHA particulates into its matrix [17].…”

Section: Introductionmentioning

confidence: 99%

Polyetheretherketone Hybrid Composites with Bioactive Nanohydroxyapatite and Multiwalled Carbon Nanotube Fillers

et al. 2016

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Polyetheretherketone (PEEK) hybrid composites reinforced with inorganic nanohydroxyapatite (nHA) and multiwalled carbon nanotube (MWNT) were prepared by melt-compounding and injection molding processes. The additions of nHA and MWNT to PEEK were aimed to increase its elastic modulus, tensile strength, and biocompatibility, rendering the hybrids suitable for load-bearing implant applications. The structural behavior, mechanical property, wettability, osteoblastic cell adhesion, proliferation, differentiation, and mineralization of the PEEK/nHA-MWNT hybrids were studied. X-ray diffraction and SEM observation showed that both nHA and MWNT fillers are incorporated into the polymer matrix of PEEK-based hybrids. Tensile tests indicated that the elastic modulus of PEEK can be increased from 3.87 to 7.13 GPa by adding 15 vol % nHA and 1.88 vol % MWNT fillers. The tensile strength and elongation at break of the PEEK/(15% nHA)-(1.88% MWNT) hybrid were 64.48 MPa and 1.74%, respectively. Thus the tensile properties of this hybrid were superior to those of human cortical bones. Water contact angle measurements revealed that the PEEK/(15% nHA)-(1.88% MWNT) hybrid is hydrophilic due to the presence of nHA. Accordingly, hydrophilic PEEK/(15% nHA)-(1.88% MWNT) hybrid promoted the adhesion, proliferation, differentiation, and mineralization of murine MC3T3-E1 osteoblasts on its surface effectively on the basis of cell culture, fluorescence microscopy, MTT assay, WST-1 assay, alkaline phosphatase activity, and Alizarin red staining tests. Thus the PEEK/(15% nHA)-(1.88% MWNT) hybrid has the potential to be used for fabricating load-bearing bone implants.

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“…Because the energy carried by each atom is very small, the influence of these atoms on the structure of the material when they act on the surface is far less than that of other modification methods. The modification depth of the surface of the material is only 2-3 nm (Kirkpatrick et al, 2013;Ajami et al, 2017). Therefore, this modification method is favored by many researchers.…”

Section: Accelerated Neutral Atom Beammentioning

confidence: 99%

“…Introduction of the hydroxyl, carboxyl, and other active groups on PEEK surface could further effectively improve PEEK's cellular compatibility and bone binding ability. Compared with the gas plasma surface modification technology, the controllable operation of ANAB on the surface of materials is between 2 and 3 nm (Ajami et al, 2017), which has little influence on the structure of PEEK and has long-term stability. However, the cost is high and the operation is complex.…”

Section: Accelerated Neutral Atom Beammentioning

confidence: 99%

Biologically Modified Polyether Ether Ketone as Dental Implant Material

Zhao

et al. 2020

Front. Bioeng. Biotechnol.

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Polyether ether ketone (PEEK) is a non-toxic polymer with elastic modulus close to human bone. Compared with metal implants, PEEK has advantages such as evasion of stress shielding effect, easy processing, and similar color as teeth, among others. Therefore, it is an excellent substitute material for titanium dental orthopedic implants. However, PEEK’s biological inertia limits its use as an implant. To change PEEK’s biological inertia and increase its binding ability with bone tissue as an implant, researchers have explored a number of modification methods to enhance PEEK’s biological activities such as cellular compatibility, osteogenic activity, and antibacterial activity. This review summarizes current biological activity modification methods for PEEK, including surface modification and blending modification, and analyzes the advantages and disadvantages of each modification method. We believe that modified PEEK will be a promising dental and orthopedic implant material.

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Augmenting the bioactivity of polyetheretherketone using a novel accelerated neutral atom beam technique

Cited by 25 publications

References 59 publications

Surface bioactivation of PEEK by neutral atom beam technology

Surface bioactivation of PEEK by neutral atom beam technology

Polyetheretherketone Hybrid Composites with Bioactive Nanohydroxyapatite and Multiwalled Carbon Nanotube Fillers

Biologically Modified Polyether Ether Ketone as Dental Implant Material

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