Augmented tendency to act and altered impulse control in alcohol use disorders

Quoilin, Caroline; Timary, Philippe de; Duqué, Julie

doi:10.1016/j.nicl.2021.102738

Cited by 5 publications

(4 citation statements)

References 72 publications

(120 reference statements)

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“…The remaining two studies investigated executive motor functions with the help of VR scenarios (Chicchi Giglioli, Pérez Gálvez, Gil Granados, & Alcañiz, 2021;Quoilin, de Timary, & Duque, 2021). By use of a VR cooking task, Chicchi Giglioli et al (2021) found that patients with AUD needed more time to complete the task and made more errors (e.g., burn food) than HCs, and beyond that, the VR paradigm discriminated reliably between AUD patients and HCs.…”

Section: Assessment Studiesmentioning

confidence: 99%

Virtual reality in the diagnostic and therapy for mental disorders: A systematic review

Wiebe

Kannen

Selaskowski

et al. 2022

Clinical Psychology Review

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Section: Assessment Studiesmentioning

confidence: 99%

Virtual reality in the diagnostic and therapy for mental disorders: A systematic review

Wiebe

Kannen

Selaskowski

et al. 2022

Clinical Psychology Review

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“…Note that because finger representations have a large degree of overlap in M1 ( 74 ), TMS pulses applied over the FDI hotspot can also elicit reliable MEPs in other finger muscles. So, during the rolling ball task, MEPs were also recorded in the abductor pollicis brevis (APB) of both hands, as successfully done in past studies ( 45 , 57 , 75 ), which allowed us to obtain measures of corticospinal excitability in a task-irrelevant muscle.…”

Section: Methodsmentioning

confidence: 99%

“…This idea comes from the observation that motor suppression is deeper when movement preparation entails overcoming sensory conflict (52,53). In addition, MEP suppression is weaker in impulsive individuals such as pathological gamblers (54) or alcohol-dependent patients (55)(56)(57)(58). Interestingly, in the latter group, the deficit in motor suppression is related to the risk of relapse and to the neurotoxic effects of alcohol in prefrontal areas (56,58).…”

Section: Introductionmentioning

confidence: 99%

Relationship between transcranial magnetic stimulation markers of motor control and clinical recovery in obsessive compulsive disorder/Gilles de la Tourette syndrome: a proof of concept case study

Quoilin,

Chaise,

Duque

et al. 2024

Front. Psychiatry

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BackgroundObsessive compulsive disorder (OCD) and Gilles de la Tourette syndrome (GTS) are neurodevelopmental disorders characterized by difficulties in controlling intrusive thoughts (obsessions) and undesired actions (tics), respectively. Both conditions have been associated with abnormal inhibition but a tangible deficit of inhibitory control abilities is controversial in GTS.MethodsHere, we examined a 25 years-old male patient with severe OCD symptoms and a mild form of GTS, where impairments in motor control were central. Transcranial magnetic stimulation (TMS) was applied over the primary motor cortex (M1) to elicit motor-evoked potentials (MEPs) during four experimental sessions, allowing us to assess the excitability of motor intracortical circuitry at rest as well as the degree of MEP suppression during action preparation, a phenomenon thought to regulate movement initiation.ResultsWhen tested for the first time, the patient presented a decent level of MEP suppression during action preparation, but he exhibited a lack of intracortical inhibition at rest, as evidenced by reduced short-interval intracortical inhibition (SICI) and long-interval intracortical inhibition (LICI). Interestingly, the patient’s symptomatology drastically improved over the course of the sessions (reduced obsessions and tics), coinciding with feedback given on his good motor control abilities. These changes were reflected in the TMS measurements, with a significant strengthening of intracortical inhibition (SICI and LICI more pronounced than previously) and a more selective tuning of MEPs during action preparation; MEPs became even more suppressed, or selectively facilitated depending on the behavioral condition in which they we probed.ConclusionThis study highlights the importance of better understanding motor inhibitory mechanisms in neurodevelopmental disorders and suggests a biofeedback approach as a potential novel treatment.

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“…Monophasic pulses were delivered using a double-coil TMS method whereby pulses are delivered over the two M1 with a 1 ms inter-pulse interval, as used in many previous studies [25,71,[73][74][75] (Fig. 1.E).…”

Section: Tms Protocolmentioning

confidence: 99%

Corticospinal suppression underlying intact movement preparation fades in late Parkinson’s disease

Wilhelm

Quoilin

Derosière

et al. 2022

Preprint

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In Parkinson's disease, neurophysiological abnormalities within the primary motor cortex have been shown to contribute to cardinal symptoms such as bradykinesia, but the exact modalities are still uncertain. Here, we propose that such impairment could involve alterations of mechanisms shaping motor activity specifically during voluntary movement preparation. Indeed, several past studies in healthy populations have suggested that a strong suppression of corticospinal excitability, called ''preparatory suppression'', propels movement execution by increasing motor neural gain. Thus, we hypothesized that a gradual alteration to this mechanism may contribute to progressive motor slowness in Parkinson's disease. We also predicted a benefit of dopamine medication in restoring correct motor neural activity during action preparation. To test these hypotheses, we investigated preparatory suppression on two consecutive days in 29 Parkinson's disease patients (ON and OFF medication) and 29 matched healthy controls. Single-pulse transcranial magnetic stimulation was applied over both primary motor cortices, eliciting concurrent motor-evoked potentials in the two hands, while subjects were either at rest or prepared a left- or right-hand response in an instructed-delay choice reaction time task. Preparatory suppression was assessed by expressing the amplitude of motor potentials evoked during movement preparation relative to those obtained at rest. These neurophysiological measures were cross-analysed with task behaviour and clinical data. Contrary to healthy controls, Parkinson's disease patients showed a lack of preparatory suppression, which appeared to depend on disease progression, but not on dopamine medication. Indeed, in relatively early disease stages, patients still exhibited partial preparatory suppression, while in later stages, they lacked it completely and even exhibited a tendency for corticospinal facilitation in the hand selected for movement execution. As expected, patients also showed increasing motor handicap with disease progression as well as a decreased movement velocity during the task, but such findings did not directly correlate with levels of preparatory suppression in our cohort. While dopamine medication had no effect on the latter, it did however globally reduce raw corticospinal excitability in the dominant hand. Taken together, our results are in line with the idea that a lack of corticospinal suppression during movement preparation in Parkinson's disease slows down response execution and illustrate the importance of considering disease stages in such investigations; they also suggest differential roles of dopamine in shaping corticospinal output in those patients. Our findings thus support the use of task-related functional markers such as preparatory suppression in future studies on motor impairment in Parkinson's disease.

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Augmented tendency to act and altered impulse control in alcohol use disorders

Cited by 5 publications

References 72 publications

Virtual reality in the diagnostic and therapy for mental disorders: A systematic review

Virtual reality in the diagnostic and therapy for mental disorders: A systematic review

Relationship between transcranial magnetic stimulation markers of motor control and clinical recovery in obsessive compulsive disorder/Gilles de la Tourette syndrome: a proof of concept case study

Corticospinal suppression underlying intact movement preparation fades in late Parkinson’s disease

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