“…Moreover, all patients received conventional simulation prior to radiation therapy resulting in the already low systematic errors. In a prior study with 158 patients, the average shifts observed at the simulation stage amounted 0.07 cm in L-R, 0.01 cm in C-C and -0.06 cm in A-P with SD of 0.36 cm, 0.24 cm and 0.43 cm, respectively [3]. In case of virtual simulation without "compensating" IGRT, larger treatment margins would have been necessary, namely 1.23 cm in the L-R, 1.21 cm in the C-C and 1.74 cm in the A-P direction.…”