Augmented Natriuretic Response to Acute Sodium Infusion after Blood Pressure Elevation with Metaraminol in Normotensive Subjects *

Vaamonde, Carlos A.; Sporn, I. Norman; Lancestremere, Ruben G.; Belsky, Joseph L.; Papper, Solomon

doi:10.1172/jci104935

Cited by 23 publications

(4 citation statements)

References 19 publications

(26 reference statements)

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“…This thesis is supported by the occurrence of 'exaggerated natriuresis' in other forms of hypertension, viz. phaeochromocytoma, hyperaldosteronism, Cushing's syndrome, and in the contralateral kidney in renovascular hypertension (Hanenson et al, 1959;Birchall et al, 1953;Birchall, Madsen & Anderson, 1964), and after elevation of blood pressure by the infusion of metaraminol (Vaamonde et al, 1964;Eisinger, 1966). Increased blood pressure, by virtue of changes in the compliance characteristics of the systemic vascular bed, might alter the systemic haemodynamic response to volume expansion OJlrych et al, 1964).…”

Section: Discussionmentioning

confidence: 99%

Intrarenal Pressure and Exaggerated Natriuresis in Essential Hypertension

et al. 1970

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1. Intrarenal pressure, estimated by measurement of wedged renal vein pressure, was elevated in patients with essential hypertension. Despite increased afferent arteriolar resistance, glomerular pressure was elevated indicating that the higher systemic pressure in essential hypertension is transmitted beyond the arterioles and accounts for elevation of intrarenal pressure.2. During hypertonic saline loading in hypertensives, renal arteriolar resistance falls, resulting in further increase in intrarenal pressure. Increments in intrarenal pressure paralleled increases in sodium excretion in patients with essential hypertension during the exaggerated natriuresis and in normotensive subjects after the prolonged infusion of hypertonic saline.3. The marked increase in intrarenal pressure which appears to be responsible for exaggerated natriuresis in essential hypertension is attributable to an altered (exaggerated) response of the renal arterioles. The data suggest that elevated intrarenal pressure may play a role in the regulation of sodium balance in patients with essential hypertension.While many investigators have noted that patients with essential hypertension excrete more sodium than normotensive subjects in response to the infusion of hypertonic saline, the mechanism for this exaggerated natriuresis is not known (Baldwin et al.

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Section: Discussionmentioning

confidence: 99%

Intrarenal Pressure and Exaggerated Natriuresis in Essential Hypertension

et al. 1970

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“…Furthermore, patients with arterial hypertension ( Figure 5) are much more prone than normal subjects to natriuresis when various pressor agents are infused (28,30). Saline-loaded normal subjects can develop this natriuretic response to pressor infusions (50).…”

Section: Discussionmentioning

confidence: 99%

Prolonged Infusions of Angiotensin II and Norepinephrine and Blood Pressure, Electrolyte Balance, and Aldosterone and Cortisol Secretion in Normal Man and in Cirrhosis with Ascites*

Ames¹,

Borkowski²,

Siciński³

et al. 1965

J. Clin. Invest.

336

116

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“…Indeed, it has been shown that individuals actually have an enhanced natriuretic response to sodium infusion following administration of metaraminol (an alpha-adrenergic agent) (124).…”

Section: Overview Of the Pathway For Development Of Hypertensionmentioning

confidence: 99%