Augmented Histamine Response After Incomplete Vagotomy

Bell, Paula; Checketts, R G; Johnston, D.; Duthie, H. L.

doi:10.1016/s0140-6736(65)92841-2

Cited by 16 publications

(3 citation statements)

References 5 publications

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“…The reduction in acid output after effective surgical vagotomy is substantially greater than the reduction during treatment with I-hyoscyamine, as is borne out by the results in the present series and in previous investigations from our and other groups ( Table 11, Bitsch, Christiansen, Faber & Rsdbro 1966, Ksster & Christiansen 1966, Bell, Checketts, Johnston & Duthie 1965. Even after an ineffective surgical vagotomy the mean reduction of acid output is greater than that obtainable during treatment with I-hyoscyamine (Bell et al 1965).…”

Section: Discussionsupporting

confidence: 66%

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Gastric Secretory Patterns before and During Treatment with 1-Hyoscyamine

Christiansen

Rødbro

1967

Scandinavian Journal of Gastroenterology

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CHRISTIANSEN, P. M. & R~D B R O , P. Gastric Secretory Patterns before and during Treatment with 1-Hyoscyamine. Scand. J. Gusfroent. 2, 251-256, 1967.Ten male patients with chronic duodenal ulceration were examined with an augmented histamine test before and during treatment with optimal effective doses of long acting 1-hyoscyamine. The outputs and secretory patterns for volume, acid, pepsin, and intrinsic factor were determined. The basal and stimulated secretion of volume and acid were significantly reduced during treatment, while the pepsin and intrinsic factor secretion were virtually unaltered. The results of acid secretion were compared to those after effective surgical vagotomy. The reduction in acid output after vagotomy was in all patients except one more pronounced than during treatment with I-hyoscyamine.

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Section: Discussionsupporting

confidence: 66%

“…Even after an ineffective surgical vagotomy the mean reduction of acid output is greater than that obtainable during treatment with I-hyoscyamine (Bell et al 1965).…”

Section: Discussionmentioning

confidence: 80%

Gastric Secretory Patterns before and During Treatment with 1-Hyoscyamine

Christiansen

Rødbro

1967

Scandinavian Journal of Gastroenterology

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“…The criteria based on acid output have been modified to conform to our 30-minute peak output measurement. By these criteria, between (Hollander, 1948) 15 R 5 13 8 0 Early positive (within first 60 min) 60 NR 6 15 11 2 (Ross and Kay, 1964;Bell et al 1965) a fifth and a half of the patients changed status between immediate and delayed tests.…”

Section: Response According To the Established Criteriamentioning

confidence: 99%

Changes in the postoperative insulin test in relation to recurrent duodenal ulceration

Watkin¹,

Duthie²

1971

Gut

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The delayed insulin test and recurrent duodenal ulceration

Watkin¹

1971

Journal of British Surgery

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It has previously been shown that insulin tests of gastric secretion carried out within 2 weeks of vagotomy and pyloroplasty give no indication of the patient's liability to recurrent duodenal ulceration. Delayed insulin tests (done 6 or more months postoperatively) have been compared in 100 patients without and 50 patients with recurrence after operation for duodenal ulceration. Complete discrimination between the groups was not achieved but the incidence of recurrence was related to the magnitude of the acid response. As no dividing line could be established to separate tests into positive and negative results, it is preferable that the actual figures for the gastric acid response to insulin be quoted. It is suggested that the peak acid concentration should be selected for this purpose. Separate estimates of the probability of recurrence associated with various levels of peak acid concentration have been made for routine insulin tests and for tests performed in patients with clinical evidence suggestive of recurrent ulceration.

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Augmented Histamine Response After Incomplete Vagotomy

Cited by 16 publications

References 5 publications

Gastric Secretory Patterns before and During Treatment with 1-Hyoscyamine

Gastric Secretory Patterns before and During Treatment with 1-Hyoscyamine

Changes in the postoperative insulin test in relation to recurrent duodenal ulceration

The delayed insulin test and recurrent duodenal ulceration

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