Augmented cocaine-induced accumbal dopamine efflux, motor activity and place preference in rats fed with a tryptophan-deficient diet

Carta, Manolo; Collu, Maria; Fadda, F; Stancampiano, Roberto

doi:10.1016/j.neulet.2006.03.002

Cited by 7 publications

(6 citation statements)

References 27 publications

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“…Consumption of a tryptophan‐deficient diet for 10 days prior to, and during conditioning enhanced the CPP effects of 7 and 10 mg/kg ip cocaine (Carta et al . 2006).…”

Section: Studies Using Systemic Drug Treatmentsmentioning

confidence: 99%

REVIEW ON CPP: Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade

2007

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Conditioned place preference (CPP) continues to be one of the most popular models to study the motivational effects of drugs and non-drug treatments in experimental animals. This is obvious from a steady year-to-year increase in the number of publications reporting the use this model. Since the compilation of the preceding review in 1998, more than 1000 new studies using place conditioning have been published, and the aim of the present review is to provide an overview of these recent publications. There are a number of trends and developments that are obvious in the literature of the last decade. First, as more and more knockout and transgenic animals become available, place conditioning is increasingly used to assess the motivational effects of drugs or non-drug rewards in genetically modified animals. Second, there is a still small but growing literature on the use of place conditioning to study the motivational aspects of pain, a field of pre-clinical research that has so far received little attention, because of the lack of appropriate animal models. Third, place conditioning continues to be widely used to study tolerance and sensitization to the rewarding effects of drugs induced by pre-treatment regimens. Fourth, extinction/reinstatement procedures in place conditioning are becoming increasingly popular. This interesting approach is thought to model certain aspects of relapse to addictive behavior and has previously almost exclusively been studied in drug self-administration paradigms. It has now also become established in the place conditioning literature and provides an additional and technically easy approach to this important phenomenon. The enormous number of studies to be covered in this review prevented in-depth discussion of many methodological, pharmacological or neurobiological aspects; to a large extent, the presentation of data had to be limited to a short and condensed summary of the most relevant findings.

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“…Consumption of a tryptophan‐deficient diet for 10 days prior to, and during conditioning enhanced the CPP effects of 7 and 10 mg/kg ip cocaine (Carta et al . 2006).…”

Section: Studies Using Systemic Drug Treatmentsmentioning

confidence: 99%

REVIEW ON CPP: Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade

2007

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“…For example, administration of a tryptophan-deficient diet to rats significantly increases locomotor activity, conditioned place preference and dopamine responses to amphetamine and cocaine. 7,28 In comparison, increasing 5-HT neurotransmission has the opposite effect, diminishing cocaine-induced striatal dopamine responses and self-administration behaviour. 8,9…”

Section: Discussionmentioning

confidence: 99%

“…7-9 Decreasing 5-HT transmission can also augment cocaine's behavioural effects, enhancing self-administration responses and increasing cocaine-induced locomotor activity, conditioned place preferences and conditioned approach. 7,10,11 Increasing 5-HT transmission, in comparison, diminishes these effects. 8,9,12 In humans, the effect of serotonergic manipulations on drug-induced dopamine responses has not been investigated.…”

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confidence: 99%

“…4-6 Moreover, increasing and decreasing 5-HT transmission can diminish and augment, respectively, the ability of drugs such as cocaine to induce a dopamine response. 7-9 Decreasing 5-HT transmission can also augment cocaine's behavioural effects, enhancing self-administration responses and increasing cocaine-induced locomotor activity, conditioned place preferences and conditioned approach. 7,10,11 Increasing 5-HT transmission, in comparison, diminishes these effects.…”

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confidence: 99%

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Effects of lowered serotonin transmission on cocaine-induced striatal dopamine response: PET [¹¹C]raclopride study in humans

Cox

Benkelfat²,

Delaney³

et al. 2011

Br J Psychiatry

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“…So far we have shown that 5-HT actions on mesocorticolimbic circuits via discrete 5-HT receptor subtypes can influence ethanol intake, but these effects can be generalized to most other drugs of abuse . Experimental manipulations that reduce brain 5-HT typically augment behavioral and dopamine responses to cocaine in humans and rodents, − and there is some evidence to suggest that reduced 5-HT activity increases sensitivity to the effects of nicotine and opiates. , However, the literature regarding the effects of 5-HT enhancing drugs on cocaine-related behaviors is incongruous with that of ethanol. Overall, SSRIs potentiate the reinforcing, discriminative and locomotor activating effects of cocaine in rodents via facilitatory actions on dopamine release in the NAc shell. − On the other hand, 5-HT precursors appear to do the opposite, , which supports the original hypothesis that 5-HT has an inhibitory effect on drug seeking behavior.…”

Section: Serotonin In the Positive Reinforcing Aspects Of Ethanol Intakementioning

confidence: 99%

Serotonergic Systems in the Pathophysiology of Ethanol Dependence: Relevance to Clinical Alcoholism

Marcinkiewcz

2015

ACS Chem. Neurosci.

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Alcoholism is a progressive brain disorder that is marked by increased sensitivity to the positive and negative reinforcing properties of ethanol, compulsive and habitual use despite negative consequences, and chronic relapse to alcohol drinking despite repeated attempts to reduce intake or abstain from alcohol. Emerging evidence from preclinical and clinical studies implicates serotonin (5-hydroxytryptamine; 5-HT) systems in the pathophysiology of alcohol dependence, suggesting that drugs targeting 5-HT systems may have utility in the treatment of alcohol use disorders. In this Review, we discuss the role of 5-HT systems in alcohol dependence with a focus on 5-HT interactions with neural circuits that govern all three stages of the addiction cycle. We attempt to clarify how 5-HT influences circuit function at these different stages with the goal of identifying neural targets for pharmacological treatment of this debilitating disorder.

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Augmented cocaine-induced accumbal dopamine efflux, motor activity and place preference in rats fed with a tryptophan-deficient diet

Cited by 7 publications

References 27 publications

REVIEW ON CPP: Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade

REVIEW ON CPP: Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade

Effects of lowered serotonin transmission on cocaine-induced striatal dopamine response: PET [¹¹C]raclopride study in humans

Serotonergic Systems in the Pathophysiology of Ethanol Dependence: Relevance to Clinical Alcoholism

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Augmented cocaine-induced accumbal dopamine efflux, motor activity and place preference in rats fed with a tryptophan-deficient diet

Cited by 7 publications

References 27 publications

REVIEW ON CPP: Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade

REVIEW ON CPP: Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade

Effects of lowered serotonin transmission on cocaine-induced striatal dopamine response: PET [11C]raclopride study in humans

Serotonergic Systems in the Pathophysiology of Ethanol Dependence: Relevance to Clinical Alcoholism

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Product

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Effects of lowered serotonin transmission on cocaine-induced striatal dopamine response: PET [¹¹C]raclopride study in humans