Augmented Buyang Huanwu Decoction facilitates axonal regeneration after peripheral nerve transection through the regulation of inflammatory cytokine production

Kim, Ki Joong; Hwang, Jinyeon; Park, Jiyeon; Namgung, Uk

doi:10.1016/j.jep.2020.113063

Cited by 10 publications

(5 citation statements)

References 69 publications

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“…BYHW can also regulate inflammatory cytokine production and facilitate axonal regeneration ( 38 ). Moreover, BYHW may assist in the timely interaction of regenerating axons and distal Schwann cells ( 39 ). Furthermore, some studies have indicated that quercetin, formononetin, isorhamnetin, and kaempferol were the main active compounds of HGW, while hydroxysafflor yellow A, astragaloside IV, ferulic acid, ligustrazine, and Z-ligustilide were mainly present in BYHW ( 40 ).…”

Section: Discussionmentioning

confidence: 99%

Beneficial effects and safety of traditional Chinese medicine for chronic inflammatory demyelinating polyradiculoneuropathy: A case report and literature review

Xie¹,

Li²,

Xie³

et al. 2023

Front. Neurol.

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Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an immune-mediated neuropathy. First-line treatments for CIDP include corticosteroids, intravenous immunoglobulin, and plasma exchange. However, the application is always limited by high costs, effectiveness, and adverse events. This study investigated a new potentially effective and safe therapeutic treatment to alleviate CIDP symptoms and improve the quality of life. In the present case, a 47-year-old rural woman presented with weakness and numbness of progressive extremities. She was diagnosed with CIDP based on abnormal cerebrospinal fluid and electromyography. The patient was treated with intravenous dexamethasone for 1 week and with Huangqi-Guizhi-Wuwu and Bu-Yang-Huan-Wu decoctions for 90 days. Surprisingly, after the treatment, the weakness and numbness were eliminated, and the quality of life improved. The varying INCAT, MRC, and BI scores also reflected the treatment effects. After 8 months of discharge, the symptoms did not relapse during the follow-up. We also searched “traditional Chinese medicine (TCM)” and “CIDP” in PubMed, EMBASE, the Web of Science, the Cochrane Library, the Chinese National Knowledge Infrastructure Databases, Wanfang Data, and the Chongqing Chinese Science and Technology Periodical Database. Finally, only ten studies were included in the literature review. Three studies were randomized controlled trials, and seven were case reports or case series. There were 419 CIDP patients, but all study sites were in China. Nine TCM formulas involving 44 herbs were reported, with Huang Qi (Astragalus membranaceus) being the most important herb. In conclusion, the case and literature demonstrated that TCM treatment might be a more effective, low-cost, and safe option for treating CIDP. Although these preliminary findings are promising, a larger sample size and higher-quality randomized clinical trials are urgently required to confirm our findings.

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Section: Discussionmentioning

confidence: 99%

Beneficial effects and safety of traditional Chinese medicine for chronic inflammatory demyelinating polyradiculoneuropathy: A case report and literature review

Xie¹,

Li²,

Xie³

et al. 2023

Front. Neurol.

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“…Previously, investigations have shown that BYHWD alleviates inflammation in many diseases in rats, such as cerebral ischemia, stroke, ischemic heart disease, Alzheimer's disease, and spinal cord injury (Iadecola and Alexander, 2001;Liu et al, 2011;Kim et al, 2020;Ryu et al, 2020). In ICH, BYHWD plays a therapeutic role through different aspects (Chen et al, 2008;Zhou et al, 2008;Cui et al, 2015;Cui et al, 2018;Kang et al, 2019;Li et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

BYHWD Alleviates Inflammatory Response by NIK-Mediated Repression of the Noncanonical NF-κB Pathway During ICH Recovery

Xiao

Luo

et al. 2021

Front. Pharmacol.

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Intracerebral hemorrhage (ICH) is a life-threatening type of stroke that lacks effective treatments. The inflammatory response following ICH is a vital response that affects brain repair and organism recovery. The nuclear factor κB (NF-κB) signaling pathway is considered one of the most important inflammatory response pathways and one of its response pathways, the noncanonical NF-κB signaling pathway, is known to be associated with persistent effect and chronic inflammation. NF-κB–inducing kinase (NIK) via the noncanonical NF-κB signaling plays a key role in controlling inflammation. Here, we investigated potential effects of the traditional Chinese medicine formula Buyang Huanwu Decoction (BYHWD) on inflammatory response in a rat model of ICH recovery by inhibiting the NIK-mediated the noncanonical NF-κB signaling pathway. In the first part, rats were randomly divided into three groups: the sham group, the ICH group, and the BYHWD group. ICH was induced in rats by injecting collagenase (type VII) into the right globus pallidus of rats' brain. For the BYHWD group, rats were administered BYHWD (4.36 g/kg) once a day by intragastric administration until they were sacrificed. Neurological function was evaluated in rats by a modified neurological severity score (mNSS), the corner turn test, and the foot-fault test. The cerebral edema showed the degree of inflammatory response by sacrificed brain water content. Western blot and real-time quantitative reverse transcription PCR tested the activity of inflammatory response and noncanonical NF-κB signaling. In the second part, siRNA treatment and assessment of inflammation level as well as alterations in the noncanonical NF-κB signaling were performed to determine whether the effect of BYHWD on inflammatory response was mediated by suppression of NIK via the noncanonical NF-κB signaling pathway. We show that BYHWD treated rats exhibited: (i) better health conditions and better neural functional recovery; (ii) decreased inflammatory cytokine and the edema; (iii) reduced expression of NIK, a key protein in unregulated the noncanonical NF-κB signaling pathways; (iv) when compared with pretreated rats with NIK targeting (NIK siRNAs), showed the same effect of inhibiting the pathway and decreased inflammatory cytokine. BYHWD can attenuate the inflammatory response during ICH recovery in rats by inhibiting the NIK-mediated noncanonical NF-κB signaling pathway.

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“…The curative effect of the study group was significantly better than that of the control group, indicating that modified Buyang Huanwu Decoction could improve CIPN symptoms. In the rat model of nerve transection and junction (NTC) [21] , BYHWD reduced the release of inflammatory cytokines (IL-1β, TNF-α) at the rejunction, regenerated axonal cells of NTC, and improved functional activity in rats after nerve injury. In a controlled study of patients with acute cerebral infarction [22] , Buyang Huanwu Decoction improved blood viscosity and hemodynamics more than aspirin, improving symptoms by improving hypoxia.…”

Section: Qi Deficiency and Blood Stasis Meridian Obstructionmentioning

confidence: 99%

Research on the Mechanism of Traditional Chinese Medicine in Treating Chemotherapy Induced Peripheral Neuropathy

2023

IJFM

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Chemotherapy-induced peripheral neuropathy (CIPN) is characterized by numbness, paresthesia and hyperalgesia at the extremities. It is a common side effect of tumor therapy and the main cause of tumor treatment failure and poor quality of life. Duloxetine is the only first-line drug recommended by the latest CIPN treatment guidelines, but its efficacy is not ideal. Modern studies show that CIPN pathogenesis is numerous, and the treatment of CIPN is still limited to a single mechanism and the treatment effect is not ideal. Clinical practice observed that Chinese medicine treatment CIPN patients can obviously alleviate pain, and modern pharmacological studies show that Chinese medicine can alleviate CIPN symptoms through a variety of mechanisms, this study on the CIPN protection mechanism and Chinese medicine treatment CIPN mechanism to do a summary.

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Augmented Buyang Huanwu Decoction facilitates axonal regeneration after peripheral nerve transection through the regulation of inflammatory cytokine production

Cited by 10 publications

References 69 publications

Beneficial effects and safety of traditional Chinese medicine for chronic inflammatory demyelinating polyradiculoneuropathy: A case report and literature review

Beneficial effects and safety of traditional Chinese medicine for chronic inflammatory demyelinating polyradiculoneuropathy: A case report and literature review

BYHWD Alleviates Inflammatory Response by NIK-Mediated Repression of the Noncanonical NF-κB Pathway During ICH Recovery

Research on the Mechanism of Traditional Chinese Medicine in Treating Chemotherapy Induced Peripheral Neuropathy

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