Augmented antioxidant status in Tamoxifen treated postmenopausal women with breast cancer on co-administration with Coenzyme Q10, Niacin and Riboflavin

Abstract

The antioxidant defense system is compromised in breast cancer patients. There is a shift in the oxidant / antioxidant balance in favor of lipid peroxidation (LPO), which could lead to tumour promotion observed in the disease. CT of CoQ(10), Niacin and Riboflavin along with TAM significantly increased the AO status, while decreasing lipid and lipid peroxides. The results suggest the necessity of therapeutic co-administration of antioxidants along with conventional drug to such patients. However, due to limited number of cases included in this study, more studies may be required to substantiate the results and arrive at a definitive conclusion, in terms of safety and efficacy of adding an AO therapy in treatment of breast cancer.

Effect of Coenzyme Q10, Riboflavin and Niacin on Tamoxifen treated postmenopausal breast cancer women with special reference to blood chemistry profiles

“…TAM does not produce visible side effects as nausea, vomiting, active infection, hair loss, etc., as in chemo or radiation therapy, but its prolonged administration for a period of 5 years causes severe biochemical derangements such as hypertriglyceridemia, hypercalcemia, deep vein thrombosis in legs, increased risk of stroke, severe oxidative stress and red blood cell hemolysis resulting in hemolytic anemia [5][6][7][8]. Due to its estrogen-like action on liver and endometrium, there is an increased risk of hepatic and endometrial carcinoma.…”

Role of Coenzyme Q10 in Breast Cancer

“…Thus, a higher enzymatic antioxidant activity will be expected in this tissue and may be the reason why a lower level of antioxidants was observed in these patients. However, the antioxidant effects measured in Yuvaraj et al [4] were a result of the combination of CoQ10, Niacin and Riboflavin. Therefore, we cannot attribute the total antioxidant effect to ubiquinone alone [4].…”

“…However, the antioxidant effects measured in Yuvaraj et al [4] were a result of the combination of CoQ10, Niacin and Riboflavin. Therefore, we cannot attribute the total antioxidant effect to ubiquinone alone [4].…”

“…Table 1 shows the studies included in this review and evaluated either the levels or effects of CoQ10 in cancer patients. Yuvaraj et al [4] conducted a randomized controlled trial where the objective was to find if co-administration of CoQ10, Niacin and Riboflavin along with Tamoxifen (TAM) could augment the antioxidant (AO) status in postmenopausal women with breast cancer. Seventy eight treated postmenopausal women younger than 70 years with resectable breast cancer were recruited.…”

Nutrition

“…un effet sur le TNF et le VEGF [63] ; • une diminution de la triglycéridémie et des VLDL [79] • et une amélioration des perturbations du bilan hépa-tique [78] chez les femmes traitées par tamoxifène.…”