Augmentation of the Craniofacial Skeleton with Porous Hydroxyapatite Granules

Hs, Byrd; Pc, Hobar; Shewmake, Kris

doi:10.1097/00006534-199301000-00003

Cited by 123 publications

(16 citation statements)

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“…In comparison, sintered and pre-shaped CaP prismatic blocks can be difficult to fill voids of irregular dimensions. Sintered CaP bioceramic blocks typically comprise of pure calcium hydroxyapatite (HA: Ca 10 (PO 4 ) 6 (OH) 2 ), pure b-tricalcium phosphate (b-TCP: b-Ca 3 (PO 4 ) 2 ) or the biphasic mixtures (HA-TCP) of the two [1][2][3]. It shall be remembered that sintered, wellcrystallized HA, TCP, and biphasic HA-TCP are good platforms for osteoconduction.…”

Section: Introductionmentioning

confidence: 99%

“…An overwhelming majority of the early examples of CaP granule synthesis routines involved a high-temperature sintering step, which resulted in the production of wellcrystallized CaP granules [4][5][6][7][8][9][10][11][12]. High-temperature sintering as a means of production was again quite popular in the later examples of CaP granule manufacturing.…”

Section: Introductionmentioning

confidence: 99%

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Preparation of porous apatite granules from calcium phosphate cement

Taş

2007

J Mater Sci: Mater Med

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A versatile method for preparing spherical, micro-and macroporous (micro: 2-10 and macro: 150-550 lm pores), carbonated apatitic calcium phosphate (Ap-CaP) granules (2-4 mm in size) was developed by using NaCl crystals as the porogen. The entire granule production was performed between 21 and 37°C. A CaP cement powder, comprising a-Ca 3 (PO 4 ) 2 (61 wt.%), CaH-PO 4 (26%), CaCO 3 (10%) and precipitated hydroxyapatite, Ca 10 (PO 4 ) 6 (OH) 2 (3%), was dry mixed with NaCl crystals varying in size from 420 lm to 1 mm. Cement powder (35 wt.%) and NaCl (65 wt.%) mixture was kneaded with an ethanol-Na 2 HPO 4 initiator solution, and the formed dough was immediately agitated on an automatic sieve shaker for a few minutes to produce the spherical granules. Embedded NaCl crystals were then leached out of the granules by soaking them in deionized water. CaP granules were micro-and macroporous with a total porosity of 50% or more. Granules were composed of carbonated, poorly crystallized, apatitic CaP phase. These were the first spherical and porous CaP granules ever produced from a self-setting calcium phosphate cement. The granules reached their final handling strength at the ambient temperature through the cement setting reaction, without having a need for sintering.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Preparation of porous apatite granules from calcium phosphate cement

Taş

2007

J Mater Sci: Mater Med

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“…In our study, 8 mm defects were created. Different bone graft materials have been used for bone regeneration, closure of osteotomy openings, and alveolar augmentation in oral and maxillofacial surgeons [19] N. Laçin et al [20]. Natural coral-derived grafts, synthetic bone graft materials, are used in al- Histological results of this study revealed that there was an increase in osteoblastic activity and significant difference in bone formation in ozone treated group [25].…”

Section: Discussionmentioning

confidence: 68%

Comparative Evaluation of Ozone Treatment in Critical Size Bone Defects Reconstructed with Alloplastic Bone Grafts

Laçin¹,

Kaya²,

Deveci³

et al. 2018

IJCM

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The purpose of this study was to investigate osteogenesis promoted by osteoconductive properties of bone grafting materials and the histopathological effects of ozone on osteogenesis. In total, 56 Winstar rats were equally divided into 4 groups. In control group, calvarial bone defect was created in 14 rats. For second group, 8 mm calvarial bone defect with ozone treatment was applied in 14 rats. For third group, an alloplastic bone graft was implanted on 8 mm calvarial bone defect. In fourth group, alloplastic bone graft was inserted in calvarial defect and ozone was treated additionally. Seven of the rats were sacrificed at the end of 4th week and the remaining 7 were sacrificed at the end of 8th week of experiment. In the study, the periosteal flaps were removed with a thin periosteal elevator and averagely 0.8 cm diameter-circular full bone defect was created with a specially designed trephine drill. The bone from the calvarial region was fixed in 10% formalin solution. After decalcification, bones were taken for routine paraffin blocking. Sections were stained with Hematoxylin-Eosin and Masson Trichrome. Histopathological findings of 4th and 8th weeks rats showed that best result for new bone formation was observed in graft + ozone treatment. It is concluded that ozone treatment increases the hemostasis in graft region, induces angiogenesis, promotes cell proliferation by preventing infiltration, induces matrix formation by influencing osteoblastic activity and has a positive effect in osteogenesis.

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“…30 years. Since 1993 it is available as porous granules [26], since 1992 as cement (non-ceramic form) [35]. The hydroxyapatite cement (HAC; BoneSource ® , Stryker Leibinger) consists of a solid (tetra calcium phosphate and dicalcium phosphate) and a liquid component (water), which show isothermal setting within 20–30 mins after mixing.…”

Section: Bone Substitutesmentioning

confidence: 99%

“…The possibility of intraoperative forming and remodelling is still considered as the essential advantage of the cement [63], however apparently it only shows little to no transformation into vital bone substance. Porous HA-granulae, which were mixed with blood and the implanted into 200 patients also showed no resorption after a period of 8 years [26] so that it is now regarded to be reliable for augmentations. Overall the resorbability of HA is considerably poor.…”

Section: Bone Substitutesmentioning

confidence: 99%

Biomaterials for craniofacial reconstruction

Neumann

2009

GMS Current Topics in Otorhinolaryngology - Head and Neck Surgery; 8:Doc08; ISSN 1865-1011

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Augmentation of the Craniofacial Skeleton with Porous Hydroxyapatite Granules

Cited by 123 publications

References 0 publications

Preparation of porous apatite granules from calcium phosphate cement

Preparation of porous apatite granules from calcium phosphate cement

Comparative Evaluation of Ozone Treatment in Critical Size Bone Defects Reconstructed with Alloplastic Bone Grafts

Biomaterials for craniofacial reconstruction

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