Augmentation of in vivo antitumour activity of xenogeneic antiserum by autotransplanted normal spleen cells in mice

Jakóbisiak, Marek; Kantoch, Michal J.; Lasek, Witold; Rozmysłowicz, Tomasz; Obłakowski, P; Dobaczewska, Hanna

doi:10.1016/0014-2964(81)90214-0

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…ADCC requires on ly a relatively low concentration of specif ic antibody to enable cytotoxic activity, and it cannot be excluded that the effector cells responsible for ADCC may even be able to cooperate with natural anti-tumor antibodies making ADCC one of the most effective defences against tumorigenesis in vivo. ADCC has already been successfully applied in experimental tumor immuno therapy [Putman et al, 1977;Minden et al, 1978;Jakobisiak et al, 1981b]. The de crease in the activity of the ADCC effector cells as is observed in preleukemic syn dromes may facilitate tumorigenesis.…”

Section: Resultsmentioning

confidence: 99%

Decreased Antibody-Dependent Cellular Cytotoxicity in Preleukemic Syndromes

Janowska‐Wieczorek

Jakóbisiak²,

Dobaczewska³

1983

Acta Haematol

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In a previous report we showed decreased antibody-dependent cellular cytotoxicity (ADCC) activity of both leukemic and non-leukemic cells in human acute leukemia. In our present study, ADCC against tumor target cells was evaluated in 13 patients with preleukemic syndromes. ADCC was found to be significantly decreased in aplastic anemia, sideroblastic anemia, paroxysmal nocturnal hemoglobinuria and pure red cell aplasia, suggesting that impairment of immune defence capacity may precede the development of leukemia in man.

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Section: Resultsmentioning

confidence: 99%

Decreased Antibody-Dependent Cellular Cytotoxicity in Preleukemic Syndromes

Janowska‐Wieczorek

Jakóbisiak²,

Dobaczewska³

1983

Acta Haematol

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Decreased Antibody‐Dependent Cellular Cytotoxicity in Various Types of Leukaemia in Man

Jakóbisiak¹,

Janowska‐Wieczorek²,

Dobaczewska³

et al. 1981

Scandinavian Journal of Haematology

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Antibody-dependent cellular cytotoxicity (ADCC) by cells from peripheral blood was studied in patients with: chronic lymphocytic leukaemia (CLL), chronic granulocytic leukaemia (CGL), acute lymphoblastic leukaemia (ALL), acute non-lymphoid leukaemia (ANLL) and compared with that of healthy donors. The ADCC activity in all the types of leukaemia was on the average lower as compared with the control values, being especially low in both CLL and CGL. Further, it has also been shown that the ADCC activity of non-leukaemic blood cells in ANLL was lower as compared with control values. The latter observation indicates that, at least in ANLL, the reduced ADCC potential of peripheral blood cells is not due to dilution of effector cells by poorly-or non-active leukaemic cells.

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Augmentation of in vivo antitumour activity of xenogeneic antiserum by autotransplanted normal spleen cells in mice

Cited by 2 publications

References 15 publications

Decreased Antibody-Dependent Cellular Cytotoxicity in Preleukemic Syndromes

Decreased Antibody-Dependent Cellular Cytotoxicity in Preleukemic Syndromes

Decreased Antibody‐Dependent Cellular Cytotoxicity in Various Types of Leukaemia in Man

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