Augmentation of implant surfaces with BMP-2 in a revision setting

Cleemann, Rasmus; Sørensen, Mette Møller; West, Andreas; Søballé, Kjeld; Bechtold, Joan E.; Baas, Jørgen

doi:10.1302/2046-3758.108.bjr-2020-0280.r1

Cited by 6 publications

(4 citation statements)

References 28 publications

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“…Establishing the best surgical option in treating musculoskeletal neoplastic and non-neoplastic conditions is ongoing. [17][18][19][20][21][22][23] Our comparison of rAPC reconstruction with osteoarticular allograft reconstruction in treating distal femoral tumours in children revealed knee stability and functional outcomes were statistically significantly better in the rAPC group, while the ROM in the knee was statistically significantly better in the osteoarticular allograft group. These findings were clinically relevant.…”

Section: Discussionmentioning

confidence: 76%

A comparison of osteoarticular allografts and allograft-prosthesis composites for reconstruction of the distal femur after resection of a bone tumour in childhood

Jamshidi

Bagherifard

Mirzaei

2022

The Bone & Joint Journal

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Aims Osteoarticular reconstruction of the distal femur in childhood has the advantage of preserving the tibial physis. However, due to the small size of the distal femur, matching the host bone with an osteoarticular allograft is challenging. In this study, we compared the outcomes and complications of a resurfaced allograft-prosthesis composite (rAPC) with those of an osteoarticular allograft to reconstruct the distal femur in children. Methods A retrospective analysis of 33 skeletally immature children with a malignant tumour of the distal femur, who underwent resection and reconstruction with a rAPC (n = 15) or osteoarticular allograft (n = 18), was conducted. The median age of the patients was ten years (interquartile range (IQR) 9 to 11) in the osteoarticular allograft group and nine years (IQR 8 to 10) in the rAPC group (p = 0.781). The median follow-up of the patients was seven years (IQR 4 to 8) in the osteoarticular allograft group and six years (IQR 3 to 7) in the rAPC group (p = 0.483). Limb function was evaluated using the Musculoskeletal Tumor Society (MSTS) score. Results At final follow-up, the knee was unstable in 9/18 patients (50%) in the osteoarticular allograft group and 2/15 patients (13%) in the rAPC group (p = 0.026). The median range of motion (ROM) of the knee was 117° (IQR 115° to 120°) in the osteoarticular allograft group and 100° (IQR 95° to 105°) in the rAPC group (p < 0.001). The median MSTS score was 25 (IQR 23 to 26) in the osteoarticular allograft group and 28 (IQR 26 to 29) in the rAPC group (p = 0.007). Osteoarthritic change was detected in 11/18 patients (61%) in the osteoarticular allograft group and in 4/15 (26%) patients in the rAPC group (p = 0.048). Conclusion In our series, a resurfaced allograft-prosthesis composite provided better knee stability and function, with a lower rate of osteoarthritis; an osteoarticular allograft was associated with better knee ROM. Cite this article: Bone Joint J 2022;104-B(10):1174–1179.

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Section: Discussionmentioning

confidence: 76%

A comparison of osteoarticular allografts and allograft-prosthesis composites for reconstruction of the distal femur after resection of a bone tumour in childhood

Jamshidi

Bagherifard

Mirzaei

2022

The Bone & Joint Journal

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“…Microstructure is an important component of bone quality, and its integrity contributes to the maintenance of bone strength ( 12 , 41 ). The microarchitectural patterns in different regions of the joint may differ ( 42 ), reflecting different types and levels of biomechanical loads ( 43 , 44 ). The primary compressive trabeculae, which have a compact microarchitecture and great biomechanical strength, bear the majority of stress on the femoral head during daily activities ( 45 ).…”

Section: Discussionmentioning

confidence: 99%

Less sclerotic microarchitecture pattern with increased bone resorption in glucocorticoid-associated osteonecrosis of femoral head as compared to alcohol-associated osteonecrosis of femoral head

Chen

Yu²,

Liu³

et al. 2023

Front. Endocrinol.

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BackgroundGlucocorticoid usage and alcohol abuse are the most widely accepted risk factors for nontraumatic osteonecrosis of femoral head (ONFH). Despite distinct etiologies between glucocorticoid-associated ONFH (GONFH) and alcohol-associated ONFH (AONFH), little is known about the differences of the microarchitectural and histomorphologic characteristics between these subtypes of ONFH.PurposesTo investigate bone microarchitecture, bone remodeling activity and histomorphology characteristics of different regions in femoral heads between GONFH and AONFH.MethodsFrom September 2015 to October 2020, 85 patients diagnosed with GONFH and AONFH were recruited. Femoral heads were obtained after total hip replacement. Femoral head specimens were obtained from 42 patients (50 hips) with GONFH and 43 patients (50 hips) with AONFH. Micro-CT was utilized to assess the microstructure of 9 regions of interest (ROIs) in the femoral head. Along the supero-inferior orientation, the femoral head was divided into necrotic region, reactive interface, and normal region; along the medio-lateral orientation, the femoral head was divided into medial region, central region and lateral region. Decalcified and undecalcified bone histology was subsequently performed to evaluate histopathological alterations and bone remodeling levels.ResultsIn the necrotic region, most of the microarchitectural parameters did not differ significantly between GONFH and AONFH, whereas both the reactive interface and normal region revealed a less sclerotic microarchitecture but a higher bone remodeling level in GONFH than AONFH. Despite similar necrotic pathological manifestations, subchondral trabecular microfracture in the necrotic region was more severe and vasculature of the reactive interface was more abundant in GONFH.ConclusionsGONFH and AONFH shared similar microarchitecture and histopathological features in the necrotic region, while GONFH exhibited a less sclerotic microarchitecture and a more active bone metabolic status in both the reactive interface and normal region. These differences between GONFH and AONFH in bone microarchitectural and histopathological characteristics might contribute to the development of disease-modifying prevention strategies and treatments for ONFH, taking into etiologies.

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“…В этом плане некоторые исследования показывают, например, что в клинической практике неудачи при использовании алломатериалов вызваны быстрой и полной деградацией материала [40]. В этом направлении имеется целая серия исследований, в которых золедронаты используются в качестве модификаторов, препятствующих избыточной резорбции костнопластического материала, содержащего стимуляторы остеогенеза (как правило, это факторы роста) [41,42].…”

Section: таблица 6 нежелательные явления отмеченные в экспериментальн...unclassified

Evaluation of Biocompatibility of New Osteoplastic Xenomaterials Containing Zoledronic Acid and Strontium Ranelate

Stogov

Дюрягина

Силантьева

et al. 2023

Traumatology and Orthopedics of Russia

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Improving the biological and functional characteristics of implantable products and materials used in traumatology and orthopedics is a topical issue. Purpose Evaluation of the biocompatibility of osteoplastic xenomaterials containing zoledronic acid and strontium ranelate. Material and methods The study was carried out on 24 male rabbits. Tested bone blocks were implanted into the cavity of femoral defects. Group 1 (n=8, control) were implanted with xenogenic bone material "Osteoplastic Matrix "Bio-Ost"". Group 2 (n=8) were implanted with bone xenogenic material impregnated with zoledronic acid. Group 3 (n=8) were implanted with xenogenic bone material impregnated with strontium ranelate. Biocompatibility was assessed using X-ray, pathomorphological, histological and laboratory methods. The follow-up period was 182 days. Results. On the 182nd day after implantation, the area of newly formed bone tissue in the defect in group 1 was 79% by median, in group 2 - 0%, in group 3 - 67%. In group 2, by this time, the maximum area was occupied by connective tissue - 77%. The relative area of fragments of the implanted material on the 182nd day in group 1 was 4% by median, in group 2 - 23%, in group 3 - 15%. In animals of all groups, no rejection of the material was noted. Signs of intoxication, inflammatory or immune reactions were not observed. There was no infection of the material. Laboratory parameters did not change significantly. In group 1, two animals had a slight migration of the implanted material under the skin, one developed arthritis of the knee joint. In all groups, one of the animals noted increase in the level of C-reactive protein on the background of leukocytosis. Conclusion Osteoplastic materials based on bovine xenomatrix saturated with zoledronic acid and strontium ranelate have acceptable biocompatibility values, including safety indicators.

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Augmentation of implant surfaces with BMP-2 in a revision setting

Cited by 6 publications

References 28 publications

A comparison of osteoarticular allografts and allograft-prosthesis composites for reconstruction of the distal femur after resection of a bone tumour in childhood

A comparison of osteoarticular allografts and allograft-prosthesis composites for reconstruction of the distal femur after resection of a bone tumour in childhood

Less sclerotic microarchitecture pattern with increased bone resorption in glucocorticoid-associated osteonecrosis of femoral head as compared to alcohol-associated osteonecrosis of femoral head

Evaluation of Biocompatibility of New Osteoplastic Xenomaterials Containing Zoledronic Acid and Strontium Ranelate

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