Augmentation of diabetic wound healing and enhancement of collagen content using nanofibrous glucophage-loaded collagen/PLGA scaffold membranes

Hydrogen Sulfide-Releasing Fibrous Membranes: Potential Patches for Stimulating Human Stem Cells Proliferation and Viability under Oxidative Stress

“…In the last years, there has been a growing interest towards plant oil-extracts with biological activity and the production of related delivery systems for several applications [35,36,37,38,39,40,41,42,43,44,45]. Among them, electrospun fibrous mats have attracted a lot of attention, being ideal for trapping and stabilizing bioactive molecules at room temperature, providing a slow-release of organic molecules and volatile compounds.…”

Electrospinning of natural polymers for advanced wound care: towards responsive and adaptive dressings

“…[70][71][72] Collagen and poly-D-L-lactide-glycolide (PLGA) scaffolds loaded with Glucophage, an anti-diabetic drug, were effective in the treatment of diabetic wounds in animal model, resulting in a rapid re-epithelialization of the skin and increased production of collagen. 73 Combinations of collagen with other natural materials will be discussed in following sections. A derivative of collagen that is highly used for biomedical applications is gelatine.…”

Biomaterials for Promoting Wound Healing in Diabetes

“…Lee et al developed a nano-fibrous collagen/poly-D-L-lactide-glycolide (PLGA) scaffold membrane by electrospinning technique. This scaffold could be applied onto diabetic wounds and loaded with drugs, providing sustained release of glucophage and promoting wound closure [21].…”

“…Fibrin [19] Collagen-GAG [20] Gelatin microcryogels [23] GAG [28] BLCC [29] Freeze-drying sponges pGIcNAc [18] Collagen sponge [27] Electrospun patches Collagen/PLGA [21] Silk fibroin [24] Biomaterials with controlledrelease of signaling molecules Nanoparticles loaded with GF/chemokines VEGF, bFGF nanoparticles in PEtU-PDMS/ fibrin [33] Curcumin loaded chitosan nanoparticles into collagen-alginate [36] With vectors encoding functional molecules AdeNOS in fibrin scaffold [37] Hyaluronic acid-MMP hydrogels with VEGF plasmids [34] GF/Chemokines preloadedd within Hydrogels Glucophage-loaded collagen/PLGA [21] Gelatin-PGA-based scaffold payload MCP-1 [35] healing benefit was associated with a more efficient vascular network. Breitbart et al seeded mouse dermal fibroblasts onto polyglycolic acid scaffold matrices, on which the cells were retrovirally transduced with the human platelet-derived growth factor B (PDGF-B) gene [28].…”