Augmentation mammoplasty and ‘silicone‐osis’

Englert, H.; Joyner, Edmund N.; Thompson, Michael D.; García, Héctor Iván; Chambers, P.; Horner, Daniel; Hunt, Christine M.; Makaroff, J.; O’Connor, Helen M.; Russell, Neil; March, Lyn

doi:10.1111/j.1445-5994.2004.00670.x

Cited by 11 publications

(7 citation statements)

References 20 publications

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“…They found that patients with silicone breast implants more commonly had complaints such as night sweats, lethargy, breast pain, impaired mentation, reflux, paraesthesiae, hand muscle weakness and myalgia [30]. …”

Section: Discussionmentioning

confidence: 99%

Two hundreds cases of ASIA syndrome following silicone implants: a comparative study of 30 years and a review of current literature

et al. 2016

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In this study, we compared one hundred patients with autoimmune/inflammatory syndrome induced by adjuvants (ASIA) due to silicone implant incompatibility syndrome diagnosed in 2014 in Maastricht, the Netherlands, with one hundred historical patients with adjuvant breast disease diagnosed in the Baylor College of Medicine, Houston, USA, between 1985 and 1992. Similarities and differences between these two cohorts were identified to determine whether the spectrum of silicone-related disease changed during the last 30 years. Patients with complaints possibly due to silicone-filled breast implants were prospectively examined in the Reinaert Clinic, Maastricht, the Netherlands between January 2014 and October 2014. All patients were evaluated for the fulfilment of ASIA criteria. Results were compared to results of the Baylor College cohort and 18 other reviewed historical cohorts. Clinical manifestations between the Maastricht and Baylor College cohorts were comparable. Fatigue was observed in 98 current patients and in 95 historical patients. Arthralgia was observed in 91 versus 81 historical patients. Myalgia was observed in 54 versus 91 patients. Cognitive impairment was observed in 78 versus 81 patients, pyrexia was observed in 64 versus 52 patients, sicca complaints in 73 versus 72 patients and severe neurological manifestations in 20 versus 32 patients. From the 54 patients who underwent removal of their silicone breast implant, 50 % (n = 27) of the patients experienced improvement of complaints after explantation of the implant. Also, in the 18 reviewed historical cohorts, similar clinical manifestations were described. Our findings suggest that no major changes were present in the observed clinical manifestations between the Maastricht and Baylor College cohorts. Also, despite changes in the principal constituents of the silicone implants during the past fifty years, silicone remained an adjuvant that may ‘bleed’ and subsequently may be a chronic stimulus to the immune system resulting in similar clinical manifestations as observed in the Maastricht cohort, the Baylor College cohort and 18 other large cohorts of patients. We therefore conclude that silicone-related disease has not changed during the last 30 years.

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Section: Discussionmentioning

confidence: 99%

Two hundreds cases of ASIA syndrome following silicone implants: a comparative study of 30 years and a review of current literature

et al. 2016

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“…38 At a more local level, a study by Lesesne on breast implants found silicone fragments 39 mainly localized to the peri-implant tissue. These particles would explain some of the systemic manifestations that per- sisted in patients even after implant removal.…”

Section: Discussionmentioning

confidence: 98%

Silsesquioxane Nanocomposites as Tissue Implants

Kannan

Salacinski

Ghanavi

et al. 2007

Plastic and Reconstructive Surgery

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“…Two studies reported a 1.8 to 2.3-fold increase in risk of morning or joint stiffness among women with breast implants compared to women with other cosmetic surgeries or from the general population (15,29). Joint swelling was not more frequently reported (12,(27)(28)(29)31).…”

Section: Ra and Joint-related Symptomsmentioning

confidence: 99%

“…Several studies also explored the risk of symptoms associated with fibromyalgia. Englert et al found that among 458 women with breast implants identified from 16 plastic surgery practices, clusters of symptoms including myalgia, stiffness, low energy, pins and needles and poor memory, among others, were increased over two-fold compared to women with non-silicone plastic surgeries (27).…”

Section: Risk Of Fibromyalgia And/or Cfsmentioning

confidence: 99%

Risk of rheumatic disease in breast implant users: a qualitative systematic review

Hoa¹,

Milord²,

Hudson³

et al. 2021

Gland Surg

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Background: Recent studies on the risk of rheumatic disease among breast implant users have reported conflicting results. The primary objective of this study was to provide a systematic and critical review of the literature on the association between breast implants and the risk of rheumatic disease.Methods: A qualitative systematic review was conducted in PubMed, MEDLINE, EMBASE, EBM-Reviews and CINAHL Complete from database inception to June 23rd, 2021. Eligible papers were full-length articles in English or French reporting original data on the incident risk of rheumatic disease among individuals with and without breast implants. Data were extracted from published reports and appraised using the Newcastle-Ottawa scale. The main outcome was incident risk of systemic sclerosis (SSc), Sjögren's syndrome (SS), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), fibromyalgia and other rheumatic disorders and symptoms.Results: Out of 3,425 identified citations, 86 met inclusion criteria. Two cohort studies suggested a twofold increase in risk of SSc, whereas three case-control studies showed no increase in risk. Three cohort studies did not find an increased risk of incident and confirmed SS among breast implant users, however symptoms of sicca, myalgia and fatigue were reported more frequently. A meta-analysis of heterogenous studies reported a less than two-fold increase in risk of RA. Studies did not support an association with SLE. Insufficient evidence was available for autoimmune myositis and other rheumatic diseases. Implant rupture detected on imaging was not clearly associated with incident rheumatic disease, although no studies specifically examined the risk associated with acute/traumatic rupture. Little data was available on the safety of saline breast implants. Explantation often led to temporary improvement. Conclusions:Based on a small number of high-quality and methodologically robust studies, an association between breast implants and a small increase in risk of SSc and RA could not be excluded. Symptoms of sicca, myalgia and fatigue were reported more frequently among breast implant users. Overall, there remains much uncertainty in regard to the association between breast implants and the risk of incident rheumatic diseases. Individuals considering the placement of breast implants should be informed of this uncertainty.

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Augmentation mammoplasty and ‘silicone‐osis’

Cited by 11 publications

References 20 publications

Two hundreds cases of ASIA syndrome following silicone implants: a comparative study of 30 years and a review of current literature

Two hundreds cases of ASIA syndrome following silicone implants: a comparative study of 30 years and a review of current literature

Silsesquioxane Nanocomposites as Tissue Implants

Risk of rheumatic disease in breast implant users: a qualitative systematic review

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