Auger Emitting Radiopharmaceuticals for Cancer Therapy

Falzone, Nadia; Cornelissen, Bart; Vallis, Katherine A.

doi:10.1007/978-94-007-2564-5_28

Cited by 4 publications

(2 citation statements)

References 92 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A schematic overview of uptake, intracellular trafficking and effects of Auger electron emitting radiopharmaceuticals (reproduced with permission from Falzone et al).…”

Section: Therapy With a Focus On Intranuclear And Dna Targetingmentioning

confidence: 99%

Imaging the inside of a tumour: a review of radionuclide imaging and theranostics targeting intracellular epitopes

Cornelissen

2014

Labelled Comp Radiopharmac

Self Cite

View full text Add to dashboard Cite

Molecular imaging of tumour tissue focusses mainly on extracellular epitopes such as tumour angiogenesis or signal transduction receptors expressed on the cell membrane. However, most biological processes that define tumour phenotype occur within the cell. In this mini-review, an overview is given of the various techniques to interrogate intracellular events using molecular imaging with radiolabelled compounds. Additionally, similar targeting techniques can be employed for radionuclide therapy using Auger electron emitters, and recent advances in Auger electron therapy are discussed.

show abstract

“…A schematic overview of uptake, intracellular trafficking and effects of Auger electron emitting radiopharmaceuticals (reproduced with permission from Falzone et al).…”

Section: Therapy With a Focus On Intranuclear And Dna Targetingmentioning

confidence: 99%

Imaging the inside of a tumour: a review of radionuclide imaging and theranostics targeting intracellular epitopes

Cornelissen

2014

Labelled Comp Radiopharmac

Self Cite

View full text Add to dashboard Cite

show abstract

“…In other words, these distances should be not longer than the size of the subcellular compartment at which the MNT is targeted. AEEs are one of the best example of such agents: their range is less than 1 μm, usually several tens of nanometers ( Falzone et al, 2012 ; Knapp and Dash, 2016 ). AEEs, in particular 125 I, attracted attention in the early 1970s ( Adelstein, 1993 ) because of surprisingly high cytotoxic effect when incorporated into DNA.…”

Section: Introductionmentioning

confidence: 99%

Modular Nanotransporters for Nuclear-Targeted Delivery of Auger Electron Emitters

Соболев

2018

Front. Pharmacol.

View full text Add to dashboard Cite

This review describes artificial modular nanotransporters (MNTs) delivering their cargos into target cells and then into the nuclei – the most vulnerable cell compartment for most anticancer agents and especially for radionuclides emitting short-range particles. The MNT strategy uses natural subcellular transport processes inherent in practically all cells including cancer cells. The MNTs use these processes just as a passenger who purchased tickets for a multiple-transfer trip making use of different kinds of public transport to reach the desired destination. The MNTs are fusion polypeptides consisting of several parts, replaceable modules, accomplishing binding to a specific receptor on the cell and subsequent internalization, endosomal escape and transport into the cell nucleus. Radionuclides emitting short-range particles, like Auger electron emitters, acquire cell specificity and significantly higher cytotoxicity both in vitro and in vivo when delivered by the MNTs into the nuclei of cancer cells. MNT modules are interchangeable, allowing replacement of receptor recognition modules, which permits their use for different types of cancer cells and, as a cocktail of several MNTs, for targeting several tumor-specific molecules for personalized medicine.

show abstract

Cross-section measurement of thulium radioisotopes with an 18 MeV medical PET cyclotron for an optimized 165Er production

Dellepiane,

Casolaro,

Favaretto

et al. 2023

Applied Radiation and Isotopes

View full text Add to dashboard Cite

Auger Emitting Radiopharmaceuticals for Cancer Therapy

Cited by 4 publications

References 92 publications

Imaging the inside of a tumour: a review of radionuclide imaging and theranostics targeting intracellular epitopes

Imaging the inside of a tumour: a review of radionuclide imaging and theranostics targeting intracellular epitopes

Modular Nanotransporters for Nuclear-Targeted Delivery of Auger Electron Emitters

Cross-section measurement of thulium radioisotopes with an 18 MeV medical PET cyclotron for an optimized 165Er production

Contact Info

Product

Resources

About