Aufnahme von Zink-65 in Mastzellen nach Degranulierung durch Kupferdinatriumäthylendiamintetraacetat

Fiedler, H; Dorsche, Herwig Hahn von; Fehrmann, P; Sulzmann, R

doi:10.1007/bf00277607

Cited by 7 publications

(3 citation statements)

References 9 publications

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“…Histamine can form a stable complex with zinc [Weitzel and Fretzdorff, 19561. The relatively high zinc content of mast cells [Angyal and Archer, 19681 and the selective uptake of zinc by these cells [Fiedler et al, 1970;Keller and Sorkin, 19701 indicate that zinc ions assist in the binding of histamine by a chelating action in these cells [Kerp, 19631. However, Bergqvist et al [1971] reported that the amount of zinc in the mast cell granules is too low to explain any chelating effect.…”

Section: Zinc As a Stabilizing Agent On Mast Cellsmentioning

confidence: 99%

Current views of zinc as a gastrohepatic protective agent

Cho

1989

Drug Development Research

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The protective effects of zinc on gastrohepatic lesions induced by various agents are reviewed. Acute gastric glandular mucosal damage produced by parenteral injection of reserpine, cold‐restraint stress or by oral administration of ethanol are prevented by zinc compounds. Hepatic lesions induced by CCl4, ethanol, alkylating agents, or cadmium are also antagonized by zinc ions. The pathological changes evoked by these agents or stress are postulated to be due to free radical production and labilization of biomembranes. These actions are thought to be sequestered or stabilized by zinc. The role of glutathione in the protective action and the involvement of mast cell degranulation in ulceration are further discussed. The data available so far indicate that zinc compounds could be used as protective agents for gastrohepatic diseases.

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Section: Zinc As a Stabilizing Agent On Mast Cellsmentioning

confidence: 99%

Current views of zinc as a gastrohepatic protective agent

Cho

1989

Drug Development Research

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“…This suggestion was based on the observations that in vitro, heparin in the presence of zinc bound 4 times more histamine than without zinc and the complex formed was 2 times stronger with zinc than without zinc [5] as well as on the ability of mast cells to take up zinc [6,7]. It should be stressed that the concentration of zinc in mast cells is about 40 times greater than in any other cells [8].…”

mentioning

confidence: 95%

“…Some authors suggested that in presence of zinc histamine may be more strongly bound to heparin within mast cell granules [5][6][7].…”

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confidence: 99%

Histamine release from mast cells by compound 48/80. The membrane action of zinc

Kazimierczak

Maśliński

1974

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The influence of both zinc chloride and unsaturated zinc: 8-Hydroxyquinoline (Zn: 8-HQ) complex on histamine release induced by compound 48/80 have been investigated. It was found that the inhibitory action of Zn: 8-HQ complex which is known to be unable to penetrate into the ceils and acts on mast cell membrane was more pronounced than the action of zinc alone.These results suggest the membrane mechanism of zinc action. The inhibitory action of zinc depends on compound 48/80 concentration when the 2 chemicals act simultaneously but it is not dependent on 48/80 concentration when zinc was added before the liberator. Zinc potentiated the histamine releasing effect of compound 48/80 when it was added after mast cells degranulation. This effect supports the hypothesis of the ionic binding of histamine in mast cells granules.

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Electron microscopic demonstration of metals in rat mast cells

1980

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This paper describes a modification of a cytochemical method for the demonstration of heavy metals. The well localized precipitate in the mast cell granules, which is also present in granules that have been separated from the cell, suggest that the metals are localized in the granules. It is demonstrated that "mast cell" grown cultures do not contain precipitate. The chelating and histamine inhibiting agent 8-hydroxyquinoline produced no changes in the histochemical pattern of the mast cell granules before nor after treatment with the histamine liberator 48/80 which provokes a release of granules from the cells. These observations suggest either that the metal (zinc) is bound to the granules in such a manner that the chelating agent cannot chemically, or based on the configuration of the metal-containing molecule, reach the metal and thereby prevent its transformation to a metal suphide.

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Aufnahme von Zink-65 in Mastzellen nach Degranulierung durch Kupferdinatriumäthylendiamintetraacetat

Cited by 7 publications

References 9 publications

Current views of zinc as a gastrohepatic protective agent

Current views of zinc as a gastrohepatic protective agent

Histamine release from mast cells by compound 48/80. The membrane action of zinc

Electron microscopic demonstration of metals in rat mast cells

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