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Thums, Barbara

doi:10.30965/9783846745052

Cited by 10 publications

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“…IR spectra were recorded as KBr pellets on a Perkin Elmer FT-IR spectrophotometer "spectrum 1000" in the range of 200-4000 cm -1 . 1 H and 13 C NMR spectra (400 MHz) were referenced to an external TMS and recorded on JEOL Eclipse 400 spectrometer. UV-Vis absorbance was performed on Shimadzu UV-2100 spectrophotometer.…”

Section: Methodsmentioning

confidence: 99%

“…Metals offer many opportunities for designing radiopharmaceuticals by modifying the environment around the metal and allowing specific in vivo targeting to be incorporated into the molecule. [1][2][3][4][5] The current interest in the development of chelating ligands for the complexation of Ga 3+ has been stimulated by the use of the Ga radionuclides, 67 Ga and 68 Ga as diagnostic agents in nuclear medicine. [6][7][8] As a part of an ongoing investigation into the design and tailoring of new binding groups for potential Ga radiopharmaceuticals, we report here the complexation of Ga 3+ by imidazole.…”

mentioning

confidence: 99%

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Synthesis, characterisation, DFT and biomedical investigation of new Ga(III) complex with imidazole

Alhokbany

Siddiqui

Mahfouz

2008

Journal of Chemical Research

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A new Ga(III) complex with imidazole (IMZ) in 1:2 Ga:IMZ stoichiometric ratio has been synthesised. The complex has been characterised by spectroscopic (IR, NMR, UV-Vis.,), thermogravimetric (TG, DTG, DTA), electrophoresis and microanalytical techniques and shown to be [GaCl(IMZ) 2 (H 2 O)]. The geometry of [GaCl(IMZ) 2 (H 2 O)] was optimised in a singlet state by the DFT method with B3LYP functional. Theoretical analysis of vibration modes of this complex has been undertaken and the results were compared with the experimental data for this compound. The complex was subjected to radiolabelling with 67 Ga via the nuclear reaction 68 Zn (p, 2n) 67 Ga. The radiochemical yield was greater than 80%. HPLC analysis in isotonic systems revealed that this complex is highly unstable in an isotonic system where it readily dissociated. The investigated complex showed relatively high anti-bacterial activities compared with the free ligand.

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Section: Methodsmentioning

confidence: 99%