Auer rods in mixed phenotype acute leukemia, T/myeloid: A report of three cases

Li, Yan; Yang, Wenrui; Wang, Wei; Lin, Dong; Wei, Hui; Wang, Ying; Liu, Bingcheng; Wang, Huijun; Xiao, Jing; Ru, Yongxin; Dong, Shuang; Wang, Jianxiang; Mi, Yingchang

doi:10.1016/j.lrr.2021.100236

Cited by 4 publications

(7 citation statements)

References 10 publications

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“…The blood test result showed neutropenia, leukocytosis, thrombocytopenia, and increased blast cell counts (Table I). In the microscopic evaluation of the peripheral blood smears, the presence of Auer rods (Figure 3) was observed, supporting the diagnosis of AML [3,8]. Taking the intraoral clinical examination with the hematological data, it was possible to suspect AML.…”

Section: Case Reportmentioning

confidence: 75%

“…In AML, the accumulation of biofilm or calculus does not need to be present for gingival enlargement to appear. This happens because, in this clinical condition, gingival hyperplasia mainly occurs due to the direct infiltration of immature leukocytes (called blasts) in the gingiva, causing gingival enlargement and, consequently, the formation of pseudopockets [8,9,12].…”

Section: Discussionmentioning

confidence: 99%

“…The uncontrolled proliferation of blasts interferes with normal hematopoiesis. Therefore, this results in neutropenia, leukocytosis, thrombocytopenia, and increased blasts in the complete blood cell count [8,12]. In addition to the hematological examination, the diagnosis of AML required a blood smear to be performed, which revealed the presence of Auer rods.…”

Section: Discussionmentioning

confidence: 99%

“…In addition to the hematological examination, the diagnosis of AML required a blood smear to be performed, which revealed the presence of Auer rods. The latter are intracytoplasmic, acidophilic corpuscles, and stickshaped crystals, a pathognomonic sign of AML [3,8,10]. In suspected cases of AML, it is critical to request hematological and histopathological tests for an early and rapid diagnosis of the disease [2].…”

Section: Discussionmentioning

confidence: 99%

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Oral manifestation in acute myeloid leukemia: case report

Ferreira¹,

Girardello²,

Pochapski³

et al. 2021

RSBO

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Oral changes can be the first signs and symptoms of systemic alterations. It is an alert to the dental surgeon, who can make an early diagnosis of a systemic alteration through oral alterations. Acute myeloid leukemia (AML) is a malignant immunosuppressive disease in which systemic alterations frequently lead to oral alterations as the first sign of the disease. The dentist must be attentive to the possible oral signs to make a quick diagnosis. Objective: To describe an unusual oral manifestation of AML, with gingival overgrowth and necrosis located on the interdental papilla on the upper central incisors. Case report: A 15-year-old female is described with AML. She presented the following oral changes as the first manifestations of the disease: gingival bleeding, petechiae, and gingival enlargement necrosis located on the interdental papilla on the upper central incisors. The dental surgeon performed an oral evaluation, and, following the clinical signs, the symptoms, and a hematological exam, AML was suspected. The patient was quickly referred to an oncologist, but she died due to the severity of the disease. Conclusion: Dentists and multidisciplinary teams have a fundamental role in the early diagnosis of diseases with primary signs in the oral cavity and caring for oncology patients.

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Section: Case Reportmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Oral manifestation in acute myeloid leukemia: case report

Ferreira¹,

Girardello²,

Pochapski³

et al. 2021

RSBO

View full text Add to dashboard Cite

show abstract

“…This is in line with the WHO 2016 classification, and even the older criteria of the European Group for the Immunological Classification of Leukemias (EGIL) would not have diagnosed a mixedphenotype acute leukemia (MPAL) but an AML with aberrant coexpression of lymphatic markers due to the CD7 expression (45,46). However, although being by far more prevalent in AML, neither Auer rods nor FLT3-ITD or CEBPA variants are exclusive to myeloid differentiation but have been previously described in ALL, especially in early T-cell precursor (ETP)-ALL (47)(48)(49)(50).…”

Section: Discussionmentioning

confidence: 99%

Broad genomic workup including optical genome mapping uncovers a DDX3X: MLLT10 gene fusion in acute myeloid leukemia

et al. 2022

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In acute myeloid leukemia (AML), treatment decisions are currently made according to the risk classification of the European LeukemiaNet (ELN), which is based on genetic alterations. Recently, optical genome mapping (OGM) as a novel method proved to yield a genome-wide and detailed cytogenetic characterization at the time of diagnosis. A young female patient suffered from a rather unexpected aggressive disease course under FLT3 targeted therapy in combination with induction chemotherapy. By applying a “next-generation diagnostic workup“ strategy with OGM and whole-exome sequencing (WES), a DDX3X: MLLT10 gene fusion could be detected, otherwise missed by routine diagnostics. Furthermore, several aspects of lineage ambiguity not shown by standard diagnostics were unraveled such as deletions of SUZ12 and ARPP21, as well as T-cell receptor recombination. In summary, the detection of this particular gene fusion DDX3X: MLLT10 in a female AML patient and the findings of lineage ambiguity are potential explanations for the aggressive course of disease. Our study demonstrates that OGM can yield novel clinically significant results, including additional information helpful in disease monitoring and disease biology.

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The impact of COVID-19 on microRNA and CD marker expression in AML patients

Saeed,

Abdulrahman,

Mohammad

2024

Sci Rep

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Acute myeloid leukaemia (AML) is an aggressive leukaemia characterised by uncontrolled blast cell proliferation. miRNAs and Clusters of Differentiation (CD) molecules play essential roles in AML progression. This study aims to investigate the effect of COVID-19 on the expression of circulating miRNA and CD molecules in AML. This cross-sectional study recruited 32 AML patients and 20 controls. Blood samples were collected and analysed using molecular cytogenetic, miRNA/mRNA expression, and flow cytometry techniques. The expression of miRNAs varied significantly between patients with AML and control individuals. The co-expression of these miRNAs was higher (P < 0.05), indicating that the presence of one miRNA led to increased expression of other miRNAs. A differential correlation was observed between miRNAs and CD markers. Additionally, miRNA 16, miRNA 21, and miRNA 221 showed significant downregulation (P < 0.05 and P < 0.01, respectively) in AML patients with COVID-19 infection compared to those without a disease. Interestingly, this study identified a higher expression level (P < 0.01) of miRNA 137 as a novel biomarker for AML patients. Moreover, the expression of miRNA 137 showed a high correlation (P < 0.05) with most of the CD markers examined in this study and FISH features data. Furthermore, a strong correlation (P < 0.01) was observed between CD markers and miRNA among AML patients with positive and negative COVID-19 infection. These data demonstrated that COVID-19 contributed to increased expression of microRNAs in AML patients. MicroRNA 137 was identified as a novel microRNA that exhibited significant differences between patients and healthy individuals, highlighting its role in AML pathogenesis.

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Auer rods in mixed phenotype acute leukemia, T/myeloid: A report of three cases

Cited by 4 publications

References 10 publications

Oral manifestation in acute myeloid leukemia: case report

Oral manifestation in acute myeloid leukemia: case report

Broad genomic workup including optical genome mapping uncovers a DDX3X: MLLT10 gene fusion in acute myeloid leukemia

The impact of COVID-19 on microRNA and CD marker expression in AML patients

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