Auditory versus visual neuroscience-informed cognitive training in schizophrenia: Effects on cognition, symptoms and quality of life

Scoriels, Linda; Genaro, Larissa T.; Mororó, Luana G.; Keffer, Stella; Guimarães, Anna Luiza; Ribeiro, Paulo V.S.; Tannos, Filippe M.; Novaes, Caroline; França, Aniela Improta; Goldenstein, Nelson; Sahakian, Barbara J.; Cavalcanti, Maria Tavares; Fisher, Melissa; Vinogradov, Sophia; Panizzutti, Rogério

doi:10.1016/j.schres.2020.05.017

Cited by 9 publications

(9 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The crucially decreased sample size in this analysis probably prevented finding any potentially significant differences between groups. In a prior report, our research group specifically explored the differences between visual and auditory exercises in a larger sample of schizophrenia subjects and found that both sensory modalities were effective, but in different ways: the visual group had broader cognitive gains and symptoms improvement than the auditory one 7 , and the auditory group appeared to be more efficacious in the enhancement of emotion processing and social cognition 43 .…”

Section: Discussionmentioning

confidence: 99%

“…Neuroscience-informed digital cognitive training has shown effectiveness in remediating cognitive deficits in schizophrenia 7 – 9 . However, response to this type of intervention has large variability, with effect sizes ranging from small to medium size 10 .…”

Section: Introductionmentioning

confidence: 99%

“…2) Could it result in different responses to neuroscience-informed digital cognitive training? To answer these questions, we measured antibody titers for T. gondii from individuals with schizophrenia who participated in a randomized, double-blind clinical trial on 40 h of neuroscience-informed cognitive training 7 .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of Toxoplasma gondii infection on cognition, symptoms, and response to digital cognitive training in schizophrenia

et al. 2022

Self Cite

View full text Add to dashboard Cite

Studies indicate that neuroscience-informed digital cognitive training can remediate cognitive impairments in schizophrenia, but the factors contributing to these deficits and response to treatment remain unclear. Toxoplasma gondii is a neuroinvasive parasite linked to cognitive decline that also presents a higher prevalence in schizophrenia. Here, we compared the cognition and symptom severity of IgG seropositive (TOXO+; n = 25) and seronegative (TOXO−; n = 35) patients who participated in a randomized controlled trial of digital cognitive training. At baseline, TOXO+ subjects presented lower global cognition than TOXO− (F = 3.78, p = 0.05). Specifically, TOXO+ subjects showed worse verbal memory and learning (F = 4.48, p = 0.03), social cognition (F = 5.71, p = 0.02), and higher antibody concentrations were associated with increased negative (r = 0.42, p = 0.04) and total (r = 0.40, p = 0.04) schizophrenia symptoms. After training, the TOXO+ group showed higher adherence to the intervention (X2 = 9.31, p = 0.03), but there were no differences in changes in cognition and symptoms between groups. These findings highlight the association between seropositivity to T. gondii and deteriorated cognition and symptoms in schizophrenia. Further research is needed to assess the specific efficacy of digital cognitive training on this population.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Toxoplasma gondii infection on cognition, symptoms, and response to digital cognitive training in schizophrenia

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, the study investigators did not determine whether treatment outcome, treatment adherence, or treatment acceptability differed based on remote treatment status. Furthermore, a study by Scoriels et al (2020) examined the efficacy of auditory and visual cognitive training on neurocognition, psychotic symptoms, and quality of life in a sample of individuals with schizophrenia. In this study participants were given the option to conduct the training sessions remotely, however, results on whether treatment outcomes differed based on remote treatment status were not provided.…”

Section: Resultsmentioning

confidence: 99%

Can cognitive remediation therapy be delivered remotely? A review examining feasibility and acceptability of remote interventions

Jagtap

Romanowska

Leibovitz

et al. 2022

Schizophrenia Research: Cognition

View full text Add to dashboard Cite

“…First, because the behavioral assessment of sensory processing to date has only been applied to the study of AT, it remains unclear whether APS can capture the enhancement of processing efficiency induced by training programs targeting sensory modalities other than the auditory domain. As novel computerized training interventions become increasingly available, including Social cognitive Training ( 31 – 34 ), and Executive Functioning Training (EFT; 31 , 34 , 35 ), it is critical to evaluate whether APS can still serve as a proxy of neural target engagement, or if new behavioral measures need to be developed and validated.…”

Section: Introductionmentioning

confidence: 99%

Specificity and Durability of Changes in Auditory Processing Efficiency After Targeted Cognitive Training in Individuals With Recent-Onset Psychosis

et al. 2020

Self Cite

View full text Add to dashboard Cite

Background: We previously demonstrated that the high heterogeneity of response to computerized Auditory Training (AT) in psychosis can be ascribed to individual differences in sensory processing efficiency and neural plasticity. In particular, we showed that Auditory Processing Speed (APS) serves as a behavioral measure of target engagement, with faster speed predicting greater transfer effects to untrained cognitive domains. Here, we investigate whether the ability of APS to function as a proxy for target engagement is unique to AT, or if it applies to other training interventions, such as Executive Functioning Training (EFT). Additionally, we examine whether changes in APS are durable after these two forms of training. Methods: One hundred and twenty-five participants with Recent Onset Psychosis (ROP) were randomized to AT (n = 66) and EFT (n = 59), respectively. APS was captured at baseline, after treatment, and at 6-month follow-up. Mixed models repeated measures analysis with restricted maximum likelihood was used to examine whether training condition differentiated APS trajectories. Within-group correlational analyses were used to study the relationship between APS and performance improvements in each of the training exercises. Results: The two groups were matched for age, gender, education, and baseline APS. Participants showed high inter-individual variability in APS at each time point. The mixed model showed a significant effect of time (F = 5.99, p = .003) but not a significant groupby-time effect (F = .73, p = .48). This was driven by significant APS improvements AT patients after treatment (d = .75) that were maintained after 6 months (d = .63). Conversely, in EFT patients, APS improvements did not reach statistical significance after treatment (p = .33) or after 6 months (p = .24). In AT patients, baseline APS (but not APS change) highly predicted peak performance for each training exercise (all r's >.42).

show abstract

Auditory versus visual neuroscience-informed cognitive training in schizophrenia: Effects on cognition, symptoms and quality of life

Cited by 9 publications

References 55 publications

Effects of Toxoplasma gondii infection on cognition, symptoms, and response to digital cognitive training in schizophrenia

Effects of Toxoplasma gondii infection on cognition, symptoms, and response to digital cognitive training in schizophrenia

Can cognitive remediation therapy be delivered remotely? A review examining feasibility and acceptability of remote interventions

Specificity and Durability of Changes in Auditory Processing Efficiency After Targeted Cognitive Training in Individuals With Recent-Onset Psychosis

Contact Info

Product

Resources

About