Auditory Thalamus Bursts in Anesthetized and Non-Anesthetized States: Contribution to Functional Properties

Massaux, Aurélie; Dutrieux, Gérard; Cotillon-Williams, Nathalie; Manunta, Yves; Edeline, Jean‐Marc

doi:10.1152/jn.00970.2003

Cited by 56 publications

(59 citation statements)

References 59 publications

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“…First, burst firing acts as an effective relay and amplifying signal in vivo [68][69][70][71]. Burst firing performs better signal detection [70,72], effectively relays auditory information in a non-linear input-output manner, regulates the frequency selectivity of MGB neurons [70,73,74], and may be involved in the generation of oscillations [75,76]. Second, RD and rebound spikes may be directly responsible for neuronal off-responses [8,77,78], which are shown by MGB neurons [79,80].…”

Section: Kir Channels Regulate Rd By Changing the Resting Membrane Pomentioning

confidence: 99%

Characterization of Rebound Depolarization in Neurons of the Rat Medial Geniculate Body In Vitro

et al. 2016

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Rebound depolarization (RD) is a response to the offset from hyperpolarization of the neuronal membrane potential and is an important mechanism for the synaptic processing of inhibitory signals. In the present study, we characterized RD in neurons of the rat medial geniculate body (MGB), a nucleus of the auditory thalamus, using whole-cell patch-clamp and brain slices. RD was proportional in strength to the duration and magnitude of the hyperpolarization; was effectively blocked by Ni 2? or Mibefradil; and was depressed when the resting membrane potential was hyperpolarized by blocking hyperpolarization-activated cyclic nucleotide-gated (HCN) channels with ZD7288 or by activating G-protein-gated inwardly-rectifying K ? (GIRK) channels with baclofen. Our results demonstrated that RD in MGB neurons, which is carried by T-type Ca 2? channels, is critically regulated by HCN channels and likely by GIRK channels.

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Section: Kir Channels Regulate Rd By Changing the Resting Membrane Pomentioning

confidence: 99%

Characterization of Rebound Depolarization in Neurons of the Rat Medial Geniculate Body In Vitro

et al. 2016

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“…To assess the burstiness of thalamic and reticular cells before, during, and after pharmacological modulation of TRN activity, we used, as an empirical gauge, the "burstiness index" used in previous studies (Edeline et al 2000;Guido et al 1992;Lu et al 1992) by computing the percentage of intervals Յ4 ms in the interspike interval distribution. Because this index is only an indirect measure of the number of bursts in spike trains, we also isolated bursts from single APs by looking for groups of two or more APs with an interspike interval Ͻ5 ms preceded by a silent period of Ն100 ms, a criteria that was previously applied to extracellular recordings in anesthetized or awake animals (Guido and Weyand 1995;Guido et al 1992;Massaux et al 2004;Ramcharan et al 2000;Gusev 2001, 2002).…”

Section: Evaluation Of the Burstiness Of Mg And Trn Neuronsmentioning

confidence: 99%

“…The frequency tuning curve and the rate-level function of each MG cell was evaluated before, during, and after drug ejection in TRN. Parts of the results were presented in an abstract format (Cotillon-Williams et al 2004).…”

Section: Introductionmentioning

confidence: 99%

Tonotopic Control of Auditory Thalamus Frequency Tuning by Reticular Thalamic Neurons

Cotillon-Williams¹,

Huetz²,

Hennevin³

et al. 2008

Journal of Neurophysiology

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Cotillon-Williams N, Huetz C, Hennevin E, Edeline J-M. Tonotopic control of auditory thalamus frequency tuning by reticular thalamic neurons. J Neurophysiol 99: 1137-1151, 2008. First published December 26, 2007 doi:10.1152/jn.01159.2007. GABAergic cells of the thalamic reticular nucleus (TRN) can potentially exert strong control over transmission of information through thalamus to the cerebral cortex. Anatomical studies have shown that the reticulothalamic connections are spatially organized in the visual, somatosensory, and auditory systems. However, the issue of how inhibitory input from TRN controls the functional properties of thalamic relay cells and whether this control follows topographic rules remains largely unknown. Here we assessed the consequences of increasing or decreasing the activity of small ensembles of TRN neurons on the receptive field properties of medial geniculate (MG) neurons. For each MG cell, the frequency tuning curve and the rate-level function were tested before, during, and after microiontophoretic applications of GABA, or of glutamate, in the auditory sector of the TRN. For 66 MG cells tested during potent pharmacological control of TRN activity, group data did not reveal any significant effects. However, for a population of 20/66 cells (all but 1 recorded in the ventral, tonotopic, division), the breadth of tuning, the frequency selectivity and the acoustic threshold were significantly modified in the directions expected from removing, or reinforcing, a dominant inhibitory input onto MG cells. Such effects occurred only when the distance between the characteristic frequency of the recorded ventral MG cell and that of the TRN cells at the ejection site was Ͻ0.25 octaves; they never occurred for larger distances. This relationship indicates that the functional interactions between TRN cells and ventral MG cells rely on precise topographic connections. I N T R O D U C T I O NThe thalamus is often considered as a "gate" for the transfer of information to neocortex. Understanding the key factors controlling this gate has been the subject of intense research, but several points remain unresolved. The reticular nucleus of the thalamus (TRN) has a key anatomical position and chemical composition to modulate thalamocortical activity. It receives inputs from both thalamus and cortex and sends outputs back to the thalamus (Jones 1975). Exclusively composed of GABAergic neurons (Arcelli et al. 1997; Benson et al. 1991;Houser et al. 1980), it is a major source of inhibition for all thalamic nuclei . In some species and for some sensory modalities, it is the quasi-exclusive source of inhibition in the thalamus, whereas in others it shares this role with local inhibitory interneurons (reviewed in Jones 1985; Sherman and Guillery 2001). The lateral geniculate nucleus possesses around 20% of inhibitory interneurons in all species (Barbaresi et al. 1986; Benson et al. 1992). The somatosensory thalamus and the auditory thalamus possess 20 -25% of inhibitory interneurons in primate and cat (Benson e...

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“…For example, in the avian brain, the selective responses for the BOS observed during periods of synchronized EEG (anesthesia or slow-wave sleep) were not observed in awake birds (Schmidt and Konishi, 1998;Schmidt, 2003, 2004). Similarly, the strength of evoked responses and the temporal discharge patterns in the mammalian auditory system differ considerably between anesthetized and awake animals (Torterolo et al, 2002;CotillonWilliams andEdeline, 2003, 2004;Massaux et al, 2004;Populin, 2005); for other references see (Hennevin et al, 2007). Thus, in the present study, to ensure that the anesthetic did not mask some aspect of the neural code that is in use in awake animals, we also analyzed neuronal spike trains recorded in the auditory cortex of awake guinea pigs.…”

Section: Introductionmentioning

confidence: 99%

A Spike-Timing Code for Discriminating Conspecific Vocalizations in the Thalamocortical System of Anesthetized and Awake Guinea Pigs

Huetz¹,

Philibert²,

Edeline³

2009

J. Neurosci.

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108

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Understanding how communication sounds are processed and encoded in the central auditory system is critical to understanding the neural bases of acoustic communication. Here, we examined neuronal representations of species-specific vocalizations, which are communication sounds that many species rely on for survival and social interaction. In some species, the evoked responses of auditory cortex neurons are stronger in response to natural conspecific vocalizations than to their time-reversed, spectrally identical, counterparts. We applied information theory-based analyses to single-unit spike trains collected in the auditory cortex (n ϭ 139) and auditory thalamus (n ϭ 135) of anesthetized animals as well as in the auditory cortex (n ϭ 119) of awake guinea pigs during presentation of four conspecific vocalizations. Few thalamic and cortical cells (Ͻ10%) displayed a firing rate preference for the natural version of these vocalizations. In contrast, when the information transmitted by the spike trains was quantified with a temporal precision of 10 -50 ms, many cells (Ͼ75%) displayed a significant amount of information (i.e., Ͼ2SD above chance levels), especially in the awake condition. The computed correlation index between spike trains (R corr , defined by Schreiber et al., 2003) indicated similar spike-timing reliability for both the natural and time-reversed versions of each vocalization, but higher reliability for awake animals compared with anesthetized animals. Based on temporal discharge patterns, even cells that were only weakly responsive to vocalizations displayed a significant level of information. These findings emphasize the importance of temporal discharge patterns as a coding mechanism for natural communication sounds, particularly in awake animals.

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Auditory Thalamus Bursts in Anesthetized and Non-Anesthetized States: Contribution to Functional Properties

Cited by 56 publications

References 59 publications

Characterization of Rebound Depolarization in Neurons of the Rat Medial Geniculate Body In Vitro

Characterization of Rebound Depolarization in Neurons of the Rat Medial Geniculate Body In Vitro

Tonotopic Control of Auditory Thalamus Frequency Tuning by Reticular Thalamic Neurons

A Spike-Timing Code for Discriminating Conspecific Vocalizations in the Thalamocortical System of Anesthetized and Awake Guinea Pigs

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