Auditory thalamocortical transformation: structure and function

Winer, Jeffery A.; Miller, Lee M.; Lee, Charles C.; Schreiner, Christoph E.

doi:10.1016/j.tins.2005.03.009

Cited by 180 publications

(137 citation statements)

References 87 publications

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“…In some cases, we found the infragranular sink iS1 to be present after drug application. This is indicative of a separate thalamocortical projection to layer V pyramidal neurons, which has been described in different anatomical studies (Budinger et al, 2000a;Huang and Winer, 2000;Linden and Schreiner, 2003;Winer et al, 2005) and a recent physiological study (Szymanski et al, 2009). …”

Section: Cortical Silencing To Dissociate Thalamocortically and Intrasupporting

confidence: 58%

“…M. Miller et al, 2001a,b;Kadia and Wang, 2003) and studies focusing on the subthreshold integration of inputs with cell-attached recording (Wehr and Zador, 2003;Liu et al, 2007) or recording of local field potentials (LFPs) (Kaur et al, 2004Metherate et al, 2005) have revealed that thalamic input of spectral information into the cortex is not relayed in a point-to-point manner. In other words, the finegrained suprathreshold representation of frequencies in primary auditory cortex cannot exclusively be inherited from afferent feedforward inputs (L. M. Miller et al, 2001a;Edeline, 2003;Wehr and Zador, 2003;Winer et al, 2005). Different short-range or long-range intracortical connections could potentially also provide spectral input to a given cortical site (Wallace et al, 1991;Budinger et al, 2000b).…”

Section: Introductionmentioning

confidence: 99%

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Spectral Integration in Primary Auditory Cortex Attributable to Temporally Precise Convergence of Thalamocortical and Intracortical Input

Happel¹,

Jeschke²,

Ohl³

2010

J. Neurosci.

128

276

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Primary sensory cortex integrates sensory information from afferent feedforward thalamocortical projection systems and convergent intracortical microcircuits. Both input systems have been demonstrated to provide different aspects of sensory information. Here we have used high-density recordings of laminar current source density (CSD) distributions in primary auditory cortex of Mongolian gerbils in combination with pharmacological silencing of cortical activity and analysis of the residual CSD, to dissociate the feedforward thalamocortical contribution and the intracortical contribution to spectral integration. We found a temporally highly precise integration of both types of inputs when the stimulation frequency was in close spectral neighborhood of the best frequency of the measurement site, in which the overlap between both inputs is maximal. Local intracortical connections provide both directly feedforward excitatory and modulatory input from adjacent cortical sites, which determine how concurrent afferent inputs are integrated. Through separate excitatory horizontal projections, terminating in cortical layers II/III, information about stimulus energy in greater spectral distance is provided even over long cortical distances. These projections effectively broaden spectral tuning width. Based on these data, we suggest a mechanism of spectral integration in primary auditory cortex that is based on temporally precise interactions of afferent thalamocortical inputs and different short-and long-range intracortical networks. The proposed conceptual framework allows integration of different and partly controversial anatomical and physiological models of spectral integration in the literature.

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Section: Cortical Silencing To Dissociate Thalamocortically and Intrasupporting

confidence: 58%

Section: Introductionmentioning

confidence: 99%

Spectral Integration in Primary Auditory Cortex Attributable to Temporally Precise Convergence of Thalamocortical and Intracortical Input

Happel¹,

Jeschke²,

Ohl³

2010

J. Neurosci.

128

276

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“…These sound-encoding differences could stem from physiologic and anatomic differences evident along the caudal-rostral axis of MGBv (Redies et al, 1989;Rodrigues-Dagaeff et al, 1989;Cant and Benson, 2007;Storace et al, 2011). However, at present there are no known anatomic or molecular indices that subdivide MGBv along its caudal-torostral axis (Morest, 1964;Clerici and Coleman, 1990;Winer et al, 1999aWiner et al, , 2005Storace et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Gene Expression Identifies Distinct Ascending Glutamatergic Pathways to Frequency-Organized Auditory Cortex in the Rat Brain

et al. 2012

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A conserved feature of sound processing across species is the presence of multiple auditory cortical fields with topographically organized responses to sound frequency. Current organizational schemes propose that the ventral division of the medial geniculate body (MGBv) is a single functionally homogenous structure that provides the primary source of input to all neighboring frequency-organized cortical fields. These schemes fail to account for the contribution of MGBv to functional diversity between frequency-organized cortical fields. Here, we report response property differences for two auditory fields in the rat, and find they have nonoverlapping sources of thalamic input from the MGBv that are distinguished by the gene expression for type 1 vesicular glutamate transporter. These data challenge widely accepted organizational schemes and demonstrate a genetic plurality in the ascending glutamatergic pathways to frequency-organized auditory cortex.

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“…Our model discards biaural interaction, and preserves the main connectivity from single cochlear signals in the Medial Geniculate nucleus to A1. A large body of evidence points to an organization of A1 with a fundamental dependency on sound frequencies along one cortical dimension, and a distribution of neural responses to temporal properties (Atzori et al, 2001;Miller, Escab, Read & Schreiner, 2002;Winer et al, 2005), model A1 has frequency and time as map dimensions. Equation (21) states the projection from the primary auditory cortex to STS.…”

Section: Auditory Pathwaymentioning

confidence: 99%

Self-Organization of Object Categories in a Cortical Artificial Model

Plebe¹

2011

Self Organizing Maps - Applications and Novel Algorithm Design

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Auditory thalamocortical transformation: structure and function

Cited by 180 publications

References 87 publications

Spectral Integration in Primary Auditory Cortex Attributable to Temporally Precise Convergence of Thalamocortical and Intracortical Input

Spectral Integration in Primary Auditory Cortex Attributable to Temporally Precise Convergence of Thalamocortical and Intracortical Input

Gene Expression Identifies Distinct Ascending Glutamatergic Pathways to Frequency-Organized Auditory Cortex in the Rat Brain

Self-Organization of Object Categories in a Cortical Artificial Model

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