Auditory temporal processing in dyslexia: An ASSR study in young children

Vanvooren, Sophie; Poelmans, Hanne; Hofmann, Michaël; Luts, Heleen; Dandache, Sophie; Ghesquière, Pol; Wouters, Jan

doi:10.1016/j.ijpsycho.2012.06.181

Cited by 2 publications

(2 citation statements)

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“…The modulation technique for ASSR stimulus can be either amplitude modulation [26][27][28] or frequency modulation [29]. It has been demonstrated that ASSR is a useful translational biomarker for several neurological and psychiatric disorders [30][31][32][33]. The ASSR is also an objective tool for estimating hearing sensitivity in individuals, especially for hearing loss [34,35], hearing assessment [36,37], and evaluation of aural rehabilitation [38].…”

Section: Introductionmentioning

confidence: 99%

The Full Informational Spectral Analysis for Auditory Steady-State Responses in Human Brain Using the Combination of Canonical Correlation Analysis and Holo-Hilbert Spectral Analysis

Lee

et al. 2022

JCM

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Auditory steady-state response (ASSR) is a translational biomarker for several neurological and psychiatric disorders, such as hearing loss, schizophrenia, bipolar disorder, autism, etc. The ASSR is sinusoidal electroencephalography (EEG)/magnetoencephalography (MEG) responses induced by periodically presented auditory stimuli. Traditional frequency analysis assumes ASSR is a stationary response, which can be analyzed using linear analysis approaches, such as Fourier analysis or Wavelet. However, recent studies have reported that the human steady-state responses are dynamic and can be modulated by the subject’s attention, wakefulness state, mental load, and mental fatigue. The amplitude modulations on the measured oscillatory responses can result in the spectral broadening or frequency splitting on the Fourier spectrum, owing to the trigonometric product-to-sum formula. Accordingly, in this study, we analyzed the human ASSR by the combination of canonical correlation analysis (CCA) and Holo-Hilbert spectral analysis (HHSA). The CCA was used to extract ASSR-related signal features, and the HHSA was used to decompose the extracted ASSR responses into amplitude modulation (AM) components and frequency modulation (FM) components, in which the FM frequency represents the fast-changing intra-mode frequency and the AM frequency represents the slow-changing inter-mode frequency. In this paper, we aimed to study the AM and FM spectra of ASSR responses in a 37 Hz steady-state auditory stimulation. Twenty-five healthy subjects were recruited for this study, and each subject was requested to participate in two auditory stimulation sessions, including one right-ear and one left-ear monaural steady-state auditory stimulation. With the HHSA, both the 37 Hz (fundamental frequency) and the 74 Hz (first harmonic frequency) auditory responses were successfully extracted. Examining the AM spectra, the 37 Hz and the 74 Hz auditory responses were modulated by distinct AM spectra, each with at least three composite frequencies. In contrast to the results of traditional Fourier spectra, frequency splitting was seen at 37 Hz, and a spectral peak was obscured at 74 Hz in Fourier spectra. The proposed method effectively corrects the frequency splitting problem resulting from time-varying amplitude changes. Our results have validated the HHSA as a useful tool for steady-state response (SSR) studies so that the misleading or wrong interpretation caused by amplitude modulation in the traditional Fourier spectrum can be avoided.

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Section: Introductionmentioning

confidence: 99%

The Full Informational Spectral Analysis for Auditory Steady-State Responses in Human Brain Using the Combination of Canonical Correlation Analysis and Holo-Hilbert Spectral Analysis

Lee

et al. 2022

JCM

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“…Even though not yet implemented, recent studies point towards other clinical applications of the ASSRs, e.g. the diagnosis of dyslexia (Poelmans et al, 2012; Vanvooren, 2015; De Vos et al, 2017) and the assessment of age-related changes in hearing that are not reflected in the audiogram (Goossens et al, 2016; Dimitrijevic et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

The effect of stimulus envelope shape on the auditory steady-state response

Canneyt

Hofmann

Wouters

et al. 2019

Preprint

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4Auditory steady-state responses (ASSRs) are auditory evoked potentials that reflect phase-locked neural activity to periodic stimuli. ASSRs are often evoked by tones with a modulated envelope, with sinusoidal envelopes being most common. However, it is unclear if and how the shape of the envelope affects ASSR responses. In this study, we used various trapezoidal modulated tones to evoke ASSRs (modulation frequency = 40 Hz) and studied the effect of four envelope parameters: attack time, hold time, decay time and off time. ASSR measurements in 20 normal hearing subjects showed that envelope shape significantly influenced responses: increased off time and/or increased decay time led to responses with a larger signal-to-noise-ratio (SNR). Response phase delay was significantly influenced by attack time and to a lesser degree by off time. We also simulated neural population responses that approximate ASSRs with a model of the auditory periphery (Bruce et al. 2018). The modulation depth of the simulated responses, i.e. the difference between maximum and minimum firing rate, correlated highly with the response SNRs found in the ASSR measurements. Longer decay time and off time enhanced the modulation depth both by decreasing the minimum firing rate and by increasing the maximum firing rate. In conclusion, custom envelopes with long decay and off time provide larger response SNRs and the benefit over the commonly used sinusoidal envelope was in the range of several dB.

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Auditory temporal processing in dyslexia: An ASSR study in young children

Cited by 2 publications

References 0 publications

The Full Informational Spectral Analysis for Auditory Steady-State Responses in Human Brain Using the Combination of Canonical Correlation Analysis and Holo-Hilbert Spectral Analysis

The Full Informational Spectral Analysis for Auditory Steady-State Responses in Human Brain Using the Combination of Canonical Correlation Analysis and Holo-Hilbert Spectral Analysis

The effect of stimulus envelope shape on the auditory steady-state response

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