Auditory sensory processing in autism: a magnetoencephalographic study

Tecchio, Franca; Benassi, Francesca; Zappasodi, Filippo; Gialloreti, Leonardo Emberti; Palermo, Mark T.; Seri, Stefano; Rossini, Paolo Maria

doi:10.1016/s0006-3223(03)00295-6

Cited by 87 publications

(75 citation statements)

References 51 publications

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“…This finding is in line with previous studies, which have failed to show a typical mismatch response to tones deviant in frequency in children with autism (e.g., [21]). A recent theory proposes that the mismatch response to deviants in an oddball paradigm arises from neuronal adaptation in auditory cortex [15].…”

Section: Discussionsupporting

confidence: 93%

Differential habituation to repeated sounds in infants at high risk for autism

et al. 2011

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Section: Discussionsupporting

confidence: 93%

Differential habituation to repeated sounds in infants at high risk for autism

et al. 2011

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“…Here, we found that mice exposed to a low dose of VPA in late gestation did not cause embryonic death, or obvious congenital abnormalities, but did alter stimulus processing in both the novel object test and the fear conditioning paradigm, indicating that prenatal exposure to VPA causes persistent changes in response to the external environment. This is broadly in line with studies of sensory processing in ASD which report impaired sensory discrimination [55], as well as dysmodulation of sensory input and motor output [56,57].…”

Section: Behaviors Altered By a Low Dose Of Vpa In Late Gestationsupporting

confidence: 90%

A single low dose of valproic acid in late prenatal life alters postnatal behavior and glutamic acid decarboxylase levels in the mouse

Wei

Lam

et al. 2016

Behavioural Brain Research

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Rationale Rodents exposed to valproic acid (VPA) in prenatal life exhibit post-natal characteristics analogous to autism spectrum disorder (ASD). Many previous studies used relatively high doses of VPA during early pregnancy, potentially confounding interpretation because the offspring are the "survivors" of a toxic insult. Low dose or late gestation exposure has not been widely studied. Objectives We examined the behavioral sequelae of late gestation exposure to low dose VPA in the mouse. We also examined postnatal levels of glutamic acid decarboxylase (GAD65 and GAD67) as markers for GABA neurons, because GABA pathology and subsequent excitatory/inhibitory imbalance is strongly implicated in ASD. Methods Pregnant C57BL/6N mice received a single subcutaneous injection of 100 or 200 mg/kg on gestation day 17. The control group received a saline injection on the same day. The offspring were tested in a battery of behavioral tests in adolescence and adulthood. Six brain regions were harvested and GAD65 and GAD67 were measured by western blotting. Results Compared to saline-exposed controls, adult mice exposed to prenatal VPA had impaired novel object exploration and fear conditioning anomalies. GAD67 was decreased in midbrain, olfactory bulb, prefrontal cortex and increased in cerebellum, hippocampus and striatum; GAD65 was decreased in all 6 regions. ConclusionsOur results suggest that a low dose of VPA in late pregnancy has persistent effects on brain development, and in particular the GABA system, which 3 may be relevant to ASD. Further attention to the impact of gestation time and dose of exposure in VPA-induced ASD models is encouraged.

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“…Recent studies on auditory sensitivity in ASD have yielded somewhat mixed findings: some find hypo-responsiveness to auditory stimuli [69], others find no differences relative to a comparison group [70], and still others report superior pitch sensitivity [71], akin to reports of enhanced visual processing [39,54]. High-functioning children with ASD apparently demonstrate superior memory for pitch, labeling and disembedding pre-exposed tones from musical chords relative to controls [72].…”

Section: Is the Deficit In Face Processing Perceptual In Nature?mentioning

confidence: 98%