Auditory selective attention modulated by tryptophan depletion in humans

Ahveninen, Jyrki; Jä̈askëlainen, Iiro P.; Pennanen, Sirpa; Liesivuori, Jyrki; Ilmoniemi, Risto J.; Kähkönen, Seppo

doi:10.1016/s0304-3940(03)00102-2

Cited by 28 publications

(28 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Attentional processes are accompanied by characteristic components in event-related potentials (Pakarinen et al, 2007). Attention to a tone enhances an early P50 component and selective attention corresponds with a processing negativity comprised of an earlier negative peak (N1) generated around the auditory cortex; subsequent features of the processing negativity are related to prefrontal activity (Ahveninen et al, 2003). During a selective attention task, ATD delayed P50 latencies and suppressed the P50 and N1 amplitudes but left the later processing negativity components associated with prefrontal activity unaffected (Ahveninen et al, 2003).…”

Section: Psychomotor Processingmentioning

confidence: 99%

Effects of acute tryptophan depletion on memory, attention and executive functions: A systematic review

Mendelsohn

Riedel

Sambeth

2009

Neuroscience & Biobehavioral Reviews

148

125

View full text Add to dashboard Cite

Section: Psychomotor Processingmentioning

confidence: 99%

Effects of acute tryptophan depletion on memory, attention and executive functions: A systematic review

Mendelsohn

Riedel

Sambeth

2009

Neuroscience & Biobehavioral Reviews

148

125

View full text Add to dashboard Cite

“…5C) and is dissociated from the mean firing rate patterns would suggest that adaptation may be regulated by a separate mechanism that is coupled to the 5-HT receptors. Modification of rate adaption could be related to attentive or aroused states, where the presence of sustained discharge patterns, as opposed to rapidly adapting firing, might be critical for auditory signal detection or discrimination (Ahveninen et al 2003;Oranje et al 2008).…”

Section: Role Of 5-ht and 5-ht 2 Receptors In A1 Neuronsmentioning

confidence: 99%

“…However, 5-HT also plays an important role in normal auditory processing in the adult brain. In humans, depletion of the 5-HT precursor tryptophan decreases the intensity dependence of auditory evoked magnetic N1/P2 dipole source activity (Käh-könen et al 2002a,b) and modulates auditory selective attention (Ahveninen et al 2003). Serotonin also modulates auditory cortical evoked potentials (Dierks et al 1999;Hegerl et al 1993;Juckel et al 1997).…”

Section: Introductionmentioning

confidence: 99%

Hearing Loss Alters Serotonergic Modulation of Intrinsic Excitability in Auditory Cortex

Rao

Basura²,

Roche³

et al. 2010

Journal of Neurophysiology

View full text Add to dashboard Cite

Sensorineural hearing loss during early childhood alters auditory cortical evoked potentials in humans and profoundly changes auditory processing in hearing-impaired animals. Multiple mechanisms underlie the early postnatal establishment of cortical circuits, but one important set of developmental mechanisms relies on the neuromodulator serotonin (5-hydroxytryptamine [5-HT]). On the other hand, early sensory activity may also regulate the establishment of adultlike 5-HT receptor expression and function. We examined the role of 5-HT in auditory cortex by first investigating how 5-HT neurotransmission and 5-HT(2) receptors influence the intrinsic excitability of layer II/III pyramidal neurons in brain slices of primary auditory cortex (A1). A brief application of 5-HT (50 μM) transiently and reversibly decreased firing rates, input resistance, and spike rate adaptation in normal postnatal day 12 (P12) to P21 rats. Compared with sham-operated animals, cochlear ablation increased excitability at P12-P21, but all the effects of 5-HT, except for the decrease in adaptation, were eliminated in both sham-operated and cochlear-ablated rats. At P30-P35, cochlear ablation did not increase intrinsic excitability compared with shams, but it did prevent a pronounced decrease in excitability that appeared 10 min after 5-HT application. We also tested whether the effects on excitability were mediated by 5-HT(2) receptors. In the presence of the 5-HT(2)-receptor antagonist, ketanserin, 5-HT significantly decreased excitability compared with 5-HT or ketanserin alone in both sham-operated and cochlear-ablated P12-P21 rats. However, at P30-P35, ketanserin had no effect in sham-operated and only a modest effect cochlear-ablated animals. The 5-HT(2)-specific agonist 5-methoxy-N,N-dimethyltryptamine also had no effect at P12-P21. These results suggest that 5-HT likely regulates pyramidal cell excitability via multiple receptor subtypes with opposing effects. These data also show that early sensorineural hearing loss affects the ability of 5-HT receptor activation to modulate A1 pyramidal cell excitability.

show abstract

“…Three studies used an active oddball task, in which frequent non-target tones were interspersed with infrequent target tones [62][63][64]. Hughes and co-workers [62] showed that none of the eventrelated potential components related to attention, namely the N1/P2 and the P300 in response to target tones, were affected by the ATD procedure.…”

Section: Selective Attentionmentioning

confidence: 99%

The Effects of Acute Tryptophan Depletion on Brain Activation During Cognition and Emotional Processing in Healthy Volunteers

Evers¹,

Sambeth²,

Ramaekers³

et al. 2010

CPD

View full text Add to dashboard Cite

Acute tryptophan depletion (ATD), a method to temporarily lower central serotonin levels, has been used to study the functioning of the serotonergic system. Relatively recent studies that examined the effects of ATD on brain activation associated with cognitive and emotional processing in healthy volunteers are reviewed. An overview of the findings in healthy volunteers is important for the interpretation of the effect of ATD on brain activation in patients with an affective disorder, such as major depression. These studies show that during response control and negative feedback processing ATD modulates the BOLD response in the inferior/orbitofrontal cortex, the anterior cingulate cortex and the dorsomedial prefrontal cortex. During emotional processing, it is consistently found that ATD modulates the BOLD response in the amygdala. These brain regions also show abnormal activation in depressed patients. However, at the moment it remains unclear if the changes induced by ATD are related to decreased basal serotonin (5-HT) release or the result of other biochemical changes that are mediated by ATD. Future studies should implement methodological improvements, explore the possibilities of new promising imaging techniques and expand investigations into the effects of ATD on basal 5-HT release and other biochemical mechanisms that might be modulated by ATD.

show abstract

Auditory selective attention modulated by tryptophan depletion in humans

Cited by 28 publications

References 15 publications

Effects of acute tryptophan depletion on memory, attention and executive functions: A systematic review

Effects of acute tryptophan depletion on memory, attention and executive functions: A systematic review

Hearing Loss Alters Serotonergic Modulation of Intrinsic Excitability in Auditory Cortex

The Effects of Acute Tryptophan Depletion on Brain Activation During Cognition and Emotional Processing in Healthy Volunteers

Contact Info

Product

Resources

About