Auditory response to intracochlear electric stimuli following furosemide treatment

Hu, Ning; Abbas, Paul J.; Miller, Charles A.; Robinson, Barbara K.; Nourski, Kirill V.; Jeng, Fuh-Cherng; Abkes, Bruce A.; Nichols, John P.

doi:10.1016/s0378-5955(03)00261-2

Cited by 29 publications

(34 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A study by Hu et al (2003) described electrically evoked compound action potentials (ECAPs) of the auditory nerve in guinea pigs temporarily deafened with furosemide. It was found that the presence of functional hair cells could affect the ECAP in several ways.…”

Section: Previous Relevant Researchmentioning

confidence: 99%

“…The effects of an acoustic masker on single-unit response properties (threshold, jitter, and relative spread) were addressed by Abbas et al (2003) and Miller et al (2003). All three measures exhibited a positive correlation with the intensity level of the acoustic masker, thus indicating a general desynchronizing effect of acoustically driven activity on single-unit responses.…”

Section: Previous Relevant Researchmentioning

confidence: 99%

“…Such a comparison was based on a qualitative description of the shapes of recovery functions, and on a quantitative description of the time constants of recovery. Hair cell activity can affect electrically evoked responses of the auditory nerve (Moxon, 1971;Hu et al, 2003) and thus may play a role in ECAP recovery from electric masking. Specifically, a high-rate electric masker stimulus might depolarize inner hair cells which, in turn, would release the neurotransmitter.…”

Section: Aims and Hypothesesmentioning

confidence: 99%

“…rather than locally, and therefore its administration does not risk direct mechanical trauma to the cochlea. As the effect of furosemide on hearing is reversible, it allows for A-B-A type comparisons, which are useful for assessing the experimental stability and attributing the effects to hair-cell functionality (Hu et al, 2003). Furosemide indirectly impedes hair cell function by inhibiting the function of the stria vascularis (Pike & Bosher, 1980;Ruggero & Rich, 1991) and reducing the endocochlear potential.…”

Section: Aims and Hypothesesmentioning

confidence: 99%

“…Administration of furosemide has been demonstrated to correlate with decreases in spontaneous activity and threshold elevations in ANFs (Sewell, 1984a(Sewell, ,1984bSearchfield et al, 2004). A limitation of using furosemide is a relatively brief period (on the order of minutes) of complete hearing loss following its administration (Hu et al, 2003). Consequently, only a limited amount of data can be collected in the deafened condition.…”

Section: Aims and Hypothesesmentioning

confidence: 99%

See 4 more Smart Citations

Acoustic–electric interactions in the guinea pig auditory nerve: Simultaneous and forward masking of the electrically evoked compound action potential

et al. 2007

Self Cite

View full text Add to dashboard Cite

The study investigated the time course of the effects of acoustic and electric stimulation on the electrically evoked compound action potential (ECAP). Adult guinea pigs were used in acute experimental sessions. Bursts of acoustic noise and high-rate (5000 pulses/s) electric pulse trains were used as maskers. Biphasic electric pulses were used as probes. ECAPs were recorded from the auditory nerve trunk.Simultaneous masking of the ECAP with acoustic noise featured an onset effect and a decrease in the amount of masking to a steady state. It was characterized by a two-component exponential function. The amount of masking increased with masker level and decreased with probe level. Poststimulatory ECAP recovery often featured a non-monotonic time course, described by a threecomponent exponent. Electric maskers produced similar post-stimulatory effects in hearing and acutely deafened subjects.Acoustic stimulation affects the ECAP in a level-and time-dependent manner. Simultaneous masking follows a time course comparable to that of adaptation to an acoustic stimulus. Refractoriness, spontaneous activity, and adaptation are suggested to play a role in ECAP recovery. Post-stimulatory changes in synchrony, possibly due to recovery of spontaneous activity and an additional hair-cell independent mechanism, are hypothesized to contribute to the observed non-monotonicity of recovery.

show abstract

Section: Previous Relevant Researchmentioning

confidence: 99%

Section: Previous Relevant Researchmentioning

confidence: 99%

Section: Aims and Hypothesesmentioning

confidence: 99%

Section: Aims and Hypothesesmentioning

confidence: 99%

Section: Aims and Hypothesesmentioning

confidence: 99%

See 3 more Smart Citations

Acoustic–electric interactions in the guinea pig auditory nerve: Simultaneous and forward masking of the electrically evoked compound action potential

et al. 2007

Self Cite

View full text Add to dashboard Cite

show abstract

Cochlear implant soft failures consensus development conference statement

Balkany

Hodges

Buchman

et al. 2005

Cochlear Implants Int.

View full text Add to dashboard Cite

This Consensus Statement was prepared by a panel of experts representing the fields of otolaryngology, audiology, speech and language pathology, communication science and engineering. Representatives to the conference were appointed by professional organizations including the American Academy of Otolaryngology-Head and Neck Surgery, the American Otological Society, the American Neurotology Society, the William House Cochlear Implant Group, the British Cochlear Implant Group, and the European Academy of Otology and NeuroOtology.The statement is based on: (1) preliminary research and consultation by a steering committee selected for their relevant experience representing the professions of individuals working with cochlear implants; (2) The statement reflects the panel's assessment of relevant information available at the time it was written. It is to be expected that new information and data are constantly being generated that may alter the recommendations of this panel. The list of references accompanying this report includes the primary sources used by the panellists in developing their preliminary statements. ObjectivesTo provide professionals working in all areas of cochlear implantation with a current consensus on the terminology, definition, diagnosis and management of suspected cochlear implant malfunctions widely referred to as 'soft failures'. ParticipantsThe panels consisted of 19 individuals directly involved in development, manufacturing and clinical application of cochlear implants. Representatives from the specialties of otolaryngology, audiology, bioengineering, speech and language pathology, communication sciences and industry participated. Interactive presentations were made during an open session in the Consensus Conference to an audience of approximately 190 professionals. EvidenceThree separate panels composed of representatives from the several disciplines involved in cochlear implantation researched, discussed and formed a preliminary statement on one of three questions. Tw o further questions were added post-hoc. Data and peer-reviewed publications were prioritized over expert opinion. The three groups were charged with investigating relevant literature in this area, gathering clinical data and drawing on the experience of each of the selected members to develop a preliminary joint statement. These statements were presented in an open forum for consideration and discussion by interested attendees. ConsensusThe panel, answering three predefined questions and two post-hoc questions, developed its final consensus based on the evidence presented by each of the three committees as well as from pertinent attendee comments presented during the open forum. Consensus StatementThe steering committee composed a draft statement that was circulated to all panellists for comment. Conflicting positions were then resolved by the panel chairs, after which a summary statement was published in Otology and Neurotology and a full statement in Cochlear Implants International.

show abstract

Prosurvival and proapoptotic intracellular signaling in rat spiral ganglion neurons in vivo after the loss of hair cells

Alam

Robinson

Huang

et al. 2007

J of Comparative Neurology

Self Cite

100

View full text Add to dashboard Cite

Neurons depend on afferent input for survival. Rats were given daily kanamycin injections from P8 to P16 to destroy hair cells, the sole afferent input to spiral ganglion neurons (SGNs). Most SGNs die over an approximately 14-week period after deafferentation. During this period, the SGN population is heterogeneous. At any given time, some SGNs exhibit apoptotic markers--TUNEL and cytochrome c loss--whereas others appear nonapoptotic. We asked whether differences among SGNs in intracellular signaling relevant to apoptotic regulation could account for this heterogeneity. cAMP response element binding protein (CREB) phosphorylation, which reflects neurotrophic signaling, is reduced in many SGNs at P16, P23, and P32, when SGNs begin to die. In particular, nearly all apoptotic SGNs exhibit reduced phospho-CREB, implying that apoptosis is due to insufficient neurotrophic support. However, >32% of SGNs maintain high phospho-CREB levels, implying access to neurotrophic support. By P60, when approximately 50% of the SGNs have died, phospho-CREB levels in surviving neurons are not reduced, and SGN death is no longer correlated with reduced phospho-CREB. Activity in the proapoptotic Jun N-terminal kinase (JNK)-Jun signaling pathway is elevated in SGNs during the cell death period. This too is heterogeneous: <42% of the SGNs exhibited high phospho-Jun levels, but nearly all SGNs undergoing apoptosis exhibited elevated phospho-Jun. Thus, heterogeneity among SGNs in prosurvival and proapoptotic signaling is correlated with apoptosis. SGN death following deafferentation has an early phase in which apoptosis is correlated with reduced phospho-CREB and a later phase in which it is not. Proapoptotic JNK-Jun signaling is tightly correlated with SGN apoptosis.

show abstract

Auditory response to intracochlear electric stimuli following furosemide treatment

Cited by 29 publications

References 25 publications

Acoustic–electric interactions in the guinea pig auditory nerve: Simultaneous and forward masking of the electrically evoked compound action potential

Acoustic–electric interactions in the guinea pig auditory nerve: Simultaneous and forward masking of the electrically evoked compound action potential

Cochlear implant soft failures consensus development conference statement

Prosurvival and proapoptotic intracellular signaling in rat spiral ganglion neurons in vivo after the loss of hair cells

Contact Info

Product

Resources

About