Auditory response properties and spatial response areas of single neurons in the pontine nuclei of the big brown bat, Eptesicus fuscus

Kamada, Tsutomu; Wu, Min; Jen, Philip H.‐S.

doi:10.1016/0006-8993(92)90079-o

Cited by 14 publications

(17 citation statements)

References 61 publications

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“…Although it is uncertain whether projections from adjacent frequency bands overlap, the topography of inputs suggests that physiological recordings should find small patches of similarly tuned neurons, without a clear tonotopic arrangement. Physiological studies in the horseshoe bat (Schuller et al, 1991) and the big brown bat (Kamada et al, 1992) confirm this.…”

Section: Extrathalamic Projections Of Iccsupporting

confidence: 58%

Projections of physiologically defined subdivisions of the inferior colliculus in the mustacbed bat: Targets in the medial geniculate body and extrathalamic nuclei

Wenstrup

Larue

Winer

1994

J of Comparative Neurology

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This study examined the output of the central nucleus of the inferior colliculus to the medial geniculate body and other parts of the nervous system in the mustached bat (Pteronotus parnellii). Small deposits of anterograde tracers (horseradish peroxidase, [3H]leucine, Phaseolus vulgaris leucoagglutinin, wheat germ agglutinin conjugated to horseradish peroxidase, or biocytin) were made at physiologically defined sites in the central nucleus representing major components of the bat's echolocation signal. The topography, frequency specificity, and axonal morphology of these outputs were studied. The medial geniculate body was a major target of inferior collicular neurons, with three distinct input patterns. The projection to the ventral division was tonotopically organized, but had a relatively sparse contribution from neurons representing frequency modulated components of the biosonar pulse. The second input was to the rostral medial geniculate body, in which projections from inferior collicular neurons representing constant frequency sonar components were separated from those representing frequency modulated components. A third input was to the suprageniculate nucleus, which received strong, topographically arranged projections. Inputs to the dorsal nucleus and medial division were also observed. Extrathalamic regions receiving input included the pontine gray, external nucleus of the inferior colliculus, pericollicular tegmentum, nucleus of the brachium of the inferior colliculus, and pretectum. These central nucleus projections differed in organization and the structure of axon terminals, suggesting different physiological influences on their target nuclei. These results demonstrate that the central nucleus has divergent projections to various sensory and premotor nuclei, besides its well-established projection to the medial geniculate body.

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Section: Extrathalamic Projections Of Iccsupporting

confidence: 58%

Projections of physiologically defined subdivisions of the inferior colliculus in the mustacbed bat: Targets in the medial geniculate body and extrathalamic nuclei

Wenstrup

Larue

Winer

1994

J of Comparative Neurology

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“…14-24 g] were used for this study. The procedures for surgery and recording were basically the same as in previous studies (Jen et al 1987(Jen et al , 1989Kamada et al 1992). Briefly, 1 or 2 days before the recording session, the flat head of a 1.8-cm nail was glued onto the exposed skull of each Nembutalanesthetized (45-50 mg · kg −1 b.w.)…”

Section: Methodsmentioning

confidence: 99%

“…The electronic instruments used to generate acoustic stimuli were the same as those used in recent studies (Jen et al 1987(Jen et al , 1989Kamada et al 1992). Briefly, continuous sine waves from an oscillator (KH model 1200) were formed into 3-ms tone pulses (0.5-ms rise-decay times) by a homemade tone-burst generator (electronic switch) driven by a stimulator (Grass S88).…”

Section: Methodsmentioning

confidence: 99%

GABAergic disinhibition changes the recovery cycle of bat inferior collicular neurons

Jen

Zheng

1997

Journal of Comparative Physiology A: Sensory, Neural, and Behav

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This study examines the contribution of GABAergic inhibition to the discharge pattern and recovery properties of 110 bat inferior collicular neurons by means of bicuculline application to their recording sites. When stimulated with single pulses, 74 (67%) neurons discharged one or two impulses (phasic responders), 19 (17%) discharged three to ten impulses (phasic bursters) and 17 (16%) discharged impulses throughout the entire stimulus duration (tonic responders). Bicuculline application changed phasic responders into phasic bursters or tonic responders, increased the number of impulses by 10-2000% and shortened the response latency of most neurons. When stimulated with pairs of sound pulses, the recovery cycles of these neurons can be described as: (1) long inhibition (n = 49, 45%); (2) short inhibition (n = 41, 37%); and (3) fast recovery (n = 20, 18%) based upon the 50% recovery time that was either longer than 20 ms, between 10 and 20 ms or shorter than 10 ms. Bicuculline application shortened the 50% recovery time of most neurons by 11-2350% allowing them to respond to pairs of sound pulses at very short interpulse intervals. These data demonstrate that GABAergic inhibition contributes significantly to auditory temporal processing.

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“…In the past, many studies have examined the directional sensitivity of the bat's auditory neurons at different brain levels (Fuzessery and Pollak 1985;Grinnell 1963;Grinnell and Grinnell 1965;Jen 1980;Jen et al , 1987Jen et al , 1989Kamada and Jen 1990;Kamada et al 1992;Manabe et al 1978;Makous and O'Neill 1986;Schlegel 1977;Schlegel et al 1988;Shimozawa et al 1974Shimozawa et al , 1984Suga 1964;. These studies determined the variation in the minimum threshold (MT) or number of impulses of single neurons, or the MT and amplitude of evoked potential responses with a sound stimulus delivered at a given repetition rate from selected azimuthal and/or elevational angles.…”

Section: Introductionmentioning

confidence: 99%

Temporally patterned pulse trains affect directional sensitivity of inferior collicular neurons of the big brown bat, Eptesicus fuscus

Jen

1996

J Comp Physiol A

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The directional sensitivity of inferior collicular neurons of the big brown bat, Eptesicus fuscus, was studied under free field stimulation conditions with 3 temporally patterned trains of sound pulses which differed in pulse repetition rate and duration. The directional sensitivity curves of 92 neurons studied can be described as hemifield, directionally-selective, or non-directional according to the variation in the number of impulses with pulse train direction. When these neurons were stimulated with all 3 pulse trains, the directional sensitivity curves of 50 neurons was unchanged but that of the other 42 neurons changed from one type into another. When these pulse trains were delivered at high pulse repetition rate and short pulse duration, they significantly sharpened the directional sensitivity of two thirds of the neurons examined by reducing the angular range and increasing the slope of their impulse directional sensitivity curves. These pulse trains also sharpened the slope of the threshold directional sensitivity curves of 25 neurons studied. However, when directional sensitivity of collicular neurons was determined with pulse trains that differed only in pulse repetition rate or in pulse duration, significant sharpening of directional sensitivity was rarely observed in all experimental conditions tested. Possible mechanisms underlying these findings are discussed.

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Auditory response properties and spatial response areas of single neurons in the pontine nuclei of the big brown bat, Eptesicus fuscus

Cited by 14 publications

References 61 publications

Projections of physiologically defined subdivisions of the inferior colliculus in the mustacbed bat: Targets in the medial geniculate body and extrathalamic nuclei

Projections of physiologically defined subdivisions of the inferior colliculus in the mustacbed bat: Targets in the medial geniculate body and extrathalamic nuclei

GABAergic disinhibition changes the recovery cycle of bat inferior collicular neurons

Temporally patterned pulse trains affect directional sensitivity of inferior collicular neurons of the big brown bat, Eptesicus fuscus

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