Auditory P3a deficits in male subjects at high risk for alcoholism

Hada, Michio; Porjesz, Bernice; Chorlian, David B.; Begleiter, Henri; Polich, John

doi:10.1016/s0006-3223(00)01049-0

Cited by 44 publications

(30 citation statements)

References 88 publications

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“…Furthermore, low P3 amplitude prior to puberty has been found to predict later substance abuse, including alcohol abuse in adolescence (Berman et al, 1993; Hill et al, 1995b; Iacono et al, 2002, 2003). In addition to P3b results, offspring of alcoholics also manifested low-amplitude P3a components in both visual (Rodriguez Holguin et al, 1999) and auditory paradigms (Hada et al, 2001). …”

Section: Chronic Alcoholism and Neuroelectrophysiologymentioning

confidence: 76%

Understanding alcohol use disorders with neuroelectrophysiology

Rangaswamy

Porjesz

2014

Handbook of Clinical Neurology

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Neurocognitive deficits associated with impairments in various brain regions and neural circuitries, particularly involving frontal lobes, have been associated with chronic alcoholism, as well as with a predisposition to develop alcohol use and related disorders (AUDs). AUD is a multifactorial disorder caused by complex interactions between behavioral, genetic, and environmental liabilities. Neuroelectrophysiological techniques are instrumental in understanding brain and behavior relationships and have also proved very useful in evaluating the genetic diathesis of alcoholism. This chapter describes findings from neuroelectrophysiological measures (electroencephalogram, event-related potentials, and event-related oscillations) related to acute and chronic effects of alcohol on the brain and those that reflect underlying deficits related to a predisposition to develop AUDs and related disorders. The utility of these measures as effective endophenotypes to identify and understand genes associated with brain electrophysiology, cognitive networks, and AUDs has also been discussed.

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Section: Chronic Alcoholism and Neuroelectrophysiologymentioning

confidence: 76%

Understanding alcohol use disorders with neuroelectrophysiology

Rangaswamy

Porjesz

2014

Handbook of Clinical Neurology

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“…In a sample of individuals at high risk (HR) for alcoholism during the performance of an auditory oddball task, Ramachandran et al (1996) reported significant reductions in both P3 amplitudes and P3-related CSD activations in the HR group over the posterior central, parietal, and occipital areas, along with prominent topographic differences in the CSD maps. Similarly, in a three stimuli auditory oddball paradigm, Hada et al (2001) found that the HR group manifested significantly lower P3a amplitudes as well as a highly differentiated CSD map characterized by more but weaker posterior sources for P3a compared to low-risk subjects.…”

Section: Alcoholismmentioning

confidence: 78%

“…CSD has also proven to successfully differentiate individuals at high risk to develop certain clinical conditions, more successfully in alcoholism (Ramachandran et al, 1996; Rodriguez Holguin et al, 1999b; Hada et al, 2001) and also in psychosis (Kayser et al, 2014) from that of healthy controls. Further, presence and absence of a specific symptom (e.g., hallucination) within a particular diagnostic category or domain (e.g., psychosis) could also be differentiated using the CSD method, namely CSD measure could elicit differences in activation patterns between schizophrenic subjects with and without hallucinations (Kayser et al, 2012).…”

Section: Summary and Discussionmentioning

confidence: 99%

The use of current source density as electrophysiological correlates in neuropsychiatric disorders: A review of human studies

Kamarajan

Pandey

Chorlian

et al. 2015

International Journal of Psychophysiology

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The use of current source density (CSD), the Laplacian of the scalp surface voltage, to map the electrical activity of the brain is a powerful method in studies of cognitive and affective phenomena. During the last few decades, mapping of CSD has been successfully applied to characterize several neuropsychiatric conditions such as alcoholism, schizophrenia, depression, anxiety disorders, childhood/developmental disorders, and neurological conditions (i.e., epilepsy and brain lesions) using electrophysiological data from resting state and during cognitive performance. Use of CSD and Laplacian measures has proven effective in elucidating topographic and activation differences between groups: i) patients with a specific diagnosis vs. healthy controls, ii) subjects at high risk for a specific diagnosis vs. low risk or normal controls, and iii) patients with specific symptom(s) vs. patients without these symptom(s). The present review outlines and summarizes the studies that have employed CSD measures in investigating several neuropsychiatric conditions. The advantages and potential of CSD-based methods in clinical and research applications along with some of the limitations inherent in the CSD-based methods are discussed in the review, as well as future directions to expand the implementation of CSD to other potential clinical applications. As CSD methods have proved to be more advantageous than using scalp potential data to understand topographic and source activations, its clinical applications offer promising potential, not only for a better understanding of a range of psychiatric conditions, but also for a variety of focal neurological disorders, including epilepsy and other conditions involving brain lesions and surgical interventions.

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“…Among controls, low reinforcement scores predicted more BOLD response contrast in the right posterior cingulate and temporal regions, and the strong and mild desires factors were unrelated to the BOLD response. To confirm these findings, we extracted each participant's signal intensity values from the regions that differed between groups (Table 2) Because individuals with family histories of AUD tend to respond abnormally to alcohol and show other neural anomalies, [59][60][61][62] we compared brain responses to alcohol pictures between those in the AUD group with family histories that were positive (FHP) and negative (FHN) for AUD. The AUD-group teens with FHP (n=9; 5 [56%] female) showed more BOLD response contrast between the alcoholic and nonalcoholic beverage pictures than the AUD-group teens with FHN (n=6; 1 [17%] female), especially in the left posterior cingulate and prefrontal, orbital, and inferior temporal gyrus.…”

Section: Resultsmentioning

confidence: 99%

Neural Response to Alcohol Stimuli in Adolescents With Alcohol Use Disorder

Tapert¹,

Cheung²,

Brown³

et al. 2003

Arch Gen Psychiatry

332

230

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These results confirm previous studies by demonstrating an association between the urge to drink alcohol and blood oxygen use in areas of the brain previously linked to reward, desire, positive affect, and episodic recall. This study extends this relationship to adolescents with relatively brief drinking histories using visual alcohol stimuli, and suggests a neural basis for response to alcohol advertisements in youths with drinking problems.

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Auditory P3a deficits in male subjects at high risk for alcoholism

Cited by 44 publications

References 88 publications

Understanding alcohol use disorders with neuroelectrophysiology

Understanding alcohol use disorders with neuroelectrophysiology

The use of current source density as electrophysiological correlates in neuropsychiatric disorders: A review of human studies

Neural Response to Alcohol Stimuli in Adolescents With Alcohol Use Disorder

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