Auditory Magnetic Response to Clicks in Children and Adults: Its Components, Hemispheric Lateralization and Repetition Suppression Effect

Orekhova, Elena V.; Butorina, Anna; Tsetlin, Marina M.; Novikova, Svetlana I.; Sokolov, Pavel A.; Elam, Mikael; Stroganova, Tatiana A.

doi:10.1007/s10548-012-0262-x

Cited by 31 publications

(56 citation statements)

References 75 publications

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“…A recent study indicated that P1m is sensitive to the place-of-articulation features of speech and their co-articulatory processes (Tavabi et al, 2007). In previous MEG studies, this component has been alternatively labeled M50 (Oram Cardy et al, 2004) or P100m (Orekhova et al, 2012(Orekhova et al, , 2013. In our previous study, this component was labeled P50m (Yoshimura et al, 2012).…”

Section: Introductionmentioning

confidence: 80%

A longitudinal study of auditory evoked field and language development in young children

et al. 2014

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The relationship between language development in early childhood and the maturation of brain functions related to the human voice remains unclear. Because the development of the auditory system likely correlates with language development in young children, we investigated the relationship between the auditory evoked field (AEF) and language development using non-invasive child-customized magnetoencephalography (MEG) in a longitudinal design. Twenty typically developing children were recruited (aged 36-75 months old at the first measurement). These children were re-investigated 11-25 months after the first measurement. The AEF component P1m was examined to investigate the developmental changes in each participant's neural brain response to vocal stimuli. In addition, we examined the relationships between brain responses and language performance. P1m peak amplitude in response to vocal stimuli significantly increased in both hemispheres in the second measurement compared to the first measurement. However, no differences were observed in P1m latency. Notably, our results reveal that children with greater increases in P1m amplitude in the left hemisphere performed better on linguistic tests. Thus, our results indicate that P1m evoked by vocal stimuli is a neurophysiological marker for language development in young children. Additionally, MEG is a technique that can be used to investigate the maturation of the auditory cortex based on auditory evoked fields in young children. This study is the first to demonstrate a significant relationship between the development of the auditory processing system and the development of language abilities in young children.

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Section: Introductionmentioning

confidence: 80%

A longitudinal study of auditory evoked field and language development in young children

et al. 2014

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“…For example, it has been reported that in some subjects, two M50 responses are observed. For example, using source modeling to examine left and right STG activity in children aged 7- to 16-years-old, Orekhova et al (2013) observed in many subjects two components preceding the M100 response; a relatively low-amplitude response at ~65 ms (observed in ~50% of the subjects in the left-hemisphere and 75% of the subjects in the right-hemisphere) and a much more prominent later response with a M50 topography at ~100 ms. In the present study, M50 was defined as the first field reversal preceding M100 (or M200 if M100 not present).…”

Section: Discussionmentioning

confidence: 99%

Missing and Delayed Auditory Responses in Young and Older Children with Autism Spectrum Disorders

Edgar

Lanza

Daina

et al. 2014

Front. Hum. Neurosci.

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Background: The development of left and right superior temporal gyrus (STG) 50 ms (M50) and 100 ms (M100) auditory responses in typically developing (TD) children and in children with autism spectrum disorder (ASD) was examined. Reflecting differential development of primary/secondary auditory areas and supporting previous studies, it was hypothesized that whereas left and right M50 STG responses would be observed equally often in younger and older children, left and right M100 STG responses would more often be absent in younger than older children. In ASD, delayed neurodevelopment would be indicated via the observation of a greater proportion of ASD than TD subjects showing missing M100 but not M50 responses in both age groups. Missing M100 responses would be observed primarily in children with ASD with language impairment (ASD + LI) (and perhaps concomitantly lower general cognitive abilities).Methods: Thirty-five TD controls, 63 ASD without language impairment (ASD − LI), and 38 ASD + LI were recruited. Binaural tones were presented. The presence or absence of a STG M50 and M100 was scored. Subjects were grouped into younger (6–10 years old) and older groups (11–15 years old).Results: Although M50 responses were observed equally often in older and younger subjects and equally often in TD and ASD, left and right M50 responses were delayed in ASD − LI and ASD + LI. Group comparisons showed that in younger subjects M100 responses were observed more often in TD than ASD + LI (90 versus 66%, p = 0.04), with no differences between TD and ASD − LI (90 versus 76%, p = 0.14) or between ASD − LI and ASD + LI (76 versus 66%, p = 0.53). In older subjects, whereas no differences were observed between TD and ASD + LI, responses were observed more often in ASD − LI than ASD + LI. Findings were similar when splitting the ASD group into lower- and higher-cognitive functioning groups.Conclusion: Although present in all groups, M50 responses were delayed in ASD. Examining the TD data, findings indicated that by 11 years, a right M100 should be observed in 100% of subjects and a left M100 in 80% of subjects. Thus, by 11 years, lack of a left and especially right M100 offers neurobiological insight into sensory processing that may underlie language or cognitive impairment.

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“…The presence of the “P1 complex” comprising two positive waves (P50 and P100) thus distinguishes child response to the auditory clicks from the adult P50-N100 waveform. Similarly to that in P50, the strong attenuation of P100 with stimulus repetition suggests its link with arousal-like processes (Orekhova et al, 2012, 2013; Stroganova et al, 2013). The P100/P100m response to binaural or contralateral monaural S1 click is normally of higher amplitude in the right hemisphere.…”

Section: Processing Of Novelty and Change In Asd: Evidence From Auditmentioning

confidence: 91%

“…In children, the P50 (P50m in MEG) response to click is followed by another positive deflection of potential (Stroganova et al, 2013) (Figure 1) or magnetic field (Orekhova et al, 2013) (Figure 2) with latency of about 90–140 ms (P100 or P100m in MEG). The presence of the “P1 complex” comprising two positive waves (P50 and P100) thus distinguishes child response to the auditory clicks from the adult P50-N100 waveform.…”

Section: Processing Of Novelty and Change In Asd: Evidence From Auditmentioning

confidence: 99%

Arousal and attention re-orienting in autism spectrum disorders: evidence from auditory event-related potentials

Orekhova

Stroganova

2014

Front. Hum. Neurosci.

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The extended phenotype of autism spectrum disorders (ASD) includes a combination of arousal regulation problems, sensory modulation difficulties, and attention re-orienting deficit. A slow and inefficient re-orienting to stimuli that appear outside of the attended sensory stream is thought to be especially detrimental for social functioning. Event-related potentials (ERPs) and magnetic fields (ERFs) may help to reveal which processing stages underlying brain response to unattended but salient sensory event are affected in individuals with ASD. Previous research focusing on two sequential stages of the brain response—automatic detection of physical changes in auditory stream, indexed by mismatch negativity (MMN), and evaluation of stimulus novelty, indexed by P3a component,—found in individuals with ASD either increased, decreased, or normal processing of deviance and novelty. The review examines these apparently conflicting results, notes gaps in previous findings, and suggests a potentially unifying hypothesis relating the dampened responses to unattended sensory events to the deficit in rapid arousal process. Specifically, “sensory gating” studies focused on pre-attentive arousal consistently demonstrated that brain response to unattended and temporally novel sound in ASD is already affected at around 100 ms after stimulus onset. We hypothesize that abnormalities in nicotinic cholinergic arousal pathways, previously reported in individuals with ASD, may contribute to these ERP/ERF aberrations and result in attention re-orienting deficit. Such cholinergic dysfunction may be present in individuals with ASD early in life and can influence both sensory processing and attention re-orienting behavior. Identification of early neurophysiological biomarkers for cholinergic deficit would help to detect infants “at risk” who can potentially benefit from particular types of therapies or interventions.

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Auditory Magnetic Response to Clicks in Children and Adults: Its Components, Hemispheric Lateralization and Repetition Suppression Effect

Cited by 31 publications

References 75 publications

A longitudinal study of auditory evoked field and language development in young children

A longitudinal study of auditory evoked field and language development in young children

Missing and Delayed Auditory Responses in Young and Older Children with Autism Spectrum Disorders

Arousal and attention re-orienting in autism spectrum disorders: evidence from auditory event-related potentials

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