Auditory hallucinations induced by trazodone

Shiotsuki, Ippei; Terao, Takeshi; Ishii, Nobuyoshi; Hatano, Koji

doi:10.1136/bcr-2014-203865

Cited by 5 publications

(2 citation statements)

References 5 publications

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“…Here we first report a case of visual hallucinations, induced by trazodone. Related findings were already observed and published in the literature, particularly auditory hallucinations induced by trazodone [ 39 ], and a disorganized type of psychosis in which the patient's psychotic symptoms included hallucinations as part of the clinical picture [ 40 ], after trazodone treatment. In all of them there was a clinical remission upon the discontinuation of the offending drug.…”

Section: Discussionsupporting

confidence: 72%

Distressing Visual Hallucinations after Treatment with Trazodone

Santos

Moreira

2017

Case Reports in Psychiatry

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Trazodone, a second-generation atypical antidepressant, is increasingly being used off-label, in the treatment of insomnia. Although generally well tolerated, trazodone treatment can be associated with some complications. We describe a case of a 60-year-old man who received trazodone for primary insomnia. He returned, to the emergency department, two days later with distressing visual hallucinations, which prompted inpatient treatment. Trazodone was discontinued, leading to a complete resolution of his visual hallucinations, and he was treated with mirtazapine for 6 months. There has been no relapse in a follow-up period of two years. Patients presenting with visual hallucinations without significant psychiatry history can be a challenging situation. We highlight the importance of careful anamnesis with an accurate medication history. Given the widespread use of trazodone, clinicians should be aware of this possible side effect.

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Section: Discussionsupporting

confidence: 72%

Distressing Visual Hallucinations after Treatment with Trazodone

Santos

Moreira

2017

Case Reports in Psychiatry

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“…Secondly, the practitioners should be prudent to assess adverse events of medication with considering the cases who do not realize the symptoms are adverse events as well the present case. In literature, there are reported cases in which auditory hallucinations were induced by selective serotonin reuptake inhibitors (SSRI) such as citalopram ( 3 ), paroxetine ( 1 ), and trazodone ( 2 ). Since all of them have interactions with serotonin, the possible involvement of serotoninergic systems in the present of auditory hallucinations was evidenced.…”

Section: Discussionmentioning

confidence: 99%

Case Report: Auditory Hallucination Induced by Amitriptyline for the Treatment of Atypical Odontalgia

et al. 2022

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Auditory hallucination is usually associated with psychiatric diseases and organic brain illness. It was rarely found as adverse events of antidepressants. Amitriptyline is considered as one of the first line medications for the psychopharmacotherapy of chronic pain including atypical odontalgia (AO) which shows chronic tooth pain without corresponding abnormalities. Anticholinergic adverse events induced by amitriptyline are usually bearable and not critical since the prescription dose is very low for the patients with AO. This is a first case report about the AO patients who showed auditory hallucination by the low dose of amitriptyline. A 43-years-old female, housewife, complained chronic toothache following dental procedures and was diagnosed as AO. Amitriptyline was initially prescribed 25 mg and gradually increased up to 60 mg with the improvement of AO symptoms in 7 months. Although the temporary recurrence was observed following to the retreatment of prosthodontic dental procedures, it improved in a few weeks. Therefore, the dose of amitriptyline was decreased, and the continuation dose was set 30 mg. In 24 months, the AO symptoms were very much improved; however, she reported that she had been heard the voices at midnight for a year. The voices were neighborhoods' and talking about the noise troubles she had claimed before. She had not realized that the voices were auditory hallucination since they were heard only at midnight infrequent and not bothering her daily life. At the time she reported auditory hallucination, she worried whether organic brain diseases are hiding because the frequency of voices was increased and sometimes occurred in daytime. The adverse event of amitriptyline was suspected since she had never had psychotic symptoms before. Amitriptyline was decreased and continued with the dose of 25 mg. Magnetic resonance imaging and psychiatric consultation revealed no abnormality of brain and in psychiatric aspects. After final prosthodontic treatment, the amitriptyline was discontinued in 30 months. Two months after the discontinuation, auditory hallucination was almost disappeared with no recurrence of AO. The present case report suggests that amitriptyline has possibility to induce auditory hallucination even in conventional dose throughout the treatment of chronic pain including AO.

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Trazodone

2014

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Auditory hallucinations induced by trazodone

Cited by 5 publications

References 5 publications

Distressing Visual Hallucinations after Treatment with Trazodone

Distressing Visual Hallucinations after Treatment with Trazodone

Case Report: Auditory Hallucination Induced by Amitriptyline for the Treatment of Atypical Odontalgia

Trazodone

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