Auditory evoked potential development in early childhood: A longitudinal study

Orlrich, Elizabeth S; Barnet, Ann B.; Weiss, Ira P.; Shanks, Betty L.

doi:10.1016/0013-4694(78)90026-3

Cited by 65 publications

(45 citation statements)

References 13 publications

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“…Evoked response latency has been inversely correlated with mental efficiency, for example I.Q. (Hendrickson & Hendrickson, unpublished observation;Ertl & Schafer, 1969;Weinberg, 1969) and age (Goodin et al, 1978;Olrich et al, 1978). It is possible that the longer evoked response latencies after A9THC are the result of depressant effects on brain activity leading to reduced 'efficiency'.…”

Section: Discussionmentioning

confidence: 99%

The seed and the soil: effect of dosage, personality and starting state on the response to delta 9 tetrahydrocannabinol in man.

Ashton¹,

Golding²,

Marsh³

et al. 1981

Brit J Clinical Pharma

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University of Newcastle-upon-Tyne, 1 The effects of two doses of A9THC (2.5 and 10 mg), delivered by paced smoking of herbal cigarettes, on CNV magnitude, subjective mood ratings and heart rate were studied in 20 subjects. 2 There were highly significant interactions between drug dosage and Extraversion and Neuroticism scores, so that the direction and degree of response to the different doses of /VTHC depended on the personality characteristics of the subjects. 3 The effects of 8 mg zV9THC and placebo, delivered in herbal cigarettes smoked naturally, on smoking behaviour, subjective mood ratings, measures of autonomic activity and auditory and visual cortical evoked responses were compared in 12 subjects. 4 Smoking behaviour, subjective 'high' rating and elevation of heart rates were the most significant discriminators between drug and placebo. The latency of some of the components of the visual evoked responses was also increased by A9THC. 5 There was a significant correlation between the effects of Q9THC on skin conductance reactivity and the basal (pre-drug) level, reactivity increasing after drug in subjects with low basal reactivity and decreasing in those with high basal levels. 6 Both experiments provided clear evidence of dose-dependent biphasic stimulant and depressant actions of A9THC on both subjective and objective measures, and these effects were influenced by the personality and the starting state of the subjects.

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Section: Discussionmentioning

confidence: 99%

The seed and the soil: effect of dosage, personality and starting state on the response to delta 9 tetrahydrocannabinol in man.

Ashton¹,

Golding²,

Marsh³

et al. 1981

Brit J Clinical Pharma

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“…CAEP methodology is especially advantageous for assessing functional maturation of the brain, as neural activity can be obtained while young participants ignore the sound input. Traditionally, sound processes associated with obligatory auditory responses have been studied in paradigms using long inter-stimulus intervals (ISIs), generally slower than one stimulus per second (Čeponienc̣ et al, 1998;Ohlrich et al, 1978;Ponton et al, 2000;. Long ISI's enhance the amplitude of CAEP components and improve signal-to-noise ratios.…”

Section: Introductionmentioning

confidence: 99%

The maturation of human evoked brain potentials to sounds presented at different stimulus rates

et al. 2008

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The current study assessed the normal development of cortical auditory evoked potentials (CAEPs) in humans presented with pure tone stimuli at relatively fast stimulus rates. Traditionally, maturation of sound processing indexed by CAEPs has been studied in paradigms using inter-stimulus intervals (ISIs) generally slower than 1 Hz. While long ISIs may enhance the amplitude of CAEP components, speech information generally occurs at more rapid rates. These slower rates of sound presentation may not accurately assess auditory cortical functions in more realistic sound environments. We examined the effect of temporal rate on the elicitation of the P1-N1-P2-N2 components to unattended sounds at four levels of stimulus onset asynchrony (SOA, onset to onset, 200, 400, 600, and 800 ms) in children grouped separately by year (ages 8, 9, 10, 11 years), in adolescents (age 16 years) and in one group of young adults (ages 22-40 years). We found that both age and stimulus rate produced profound changes in CAEP morphology. Between the ages of 8-11 years, the P1 and N2 components dominated the ERP waveform at all stimulus rates. N1, the dominant CAEP component in adults, appeared as a bifurcation in a broad positive peak at earlier ages, and did not emerge as a separate component until adolescence. While the P1-N1-P2 components are more "adult-like" than "child-like" in the adolescent subjects, the N2 component, a hallmark of the child obligatory response, was still present. Faster rates resulted in the suppression of discrete components such that by 200 ms, only P1 in the adults and adolescents, and both P1 and N2 in the youngest children were discernable. We conclude that both age and ISI are important variables in the assessment of auditory cortex function and maturation. The presence of N2 in adolescents indicates that auditory cortical maturation persists into teen years.

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“…Some authors stated that the increase in the P-300 Long Latency Auditory Evoked Potential happens in a non-linear fashion with age 24,22 , and others do not see such linearity 23 . As far as the individuals' gender was concerned, some papers 21,30 did not find statistically significant differences. In a study carried out to measure the P-300 Long Latency Auditory Evoked Potential in a population made up of healthy individuals with ages varying between 21 and 35 years, in which the TDH 39 phone was used, there was no statistically significant difference between the genders when comparing P3 component amplitude and latency, however, such difference does exist when we compare the N2 component 10 .…”

Section: Introductionmentioning

confidence: 99%

Potencial evocado auditivo de longa latência-P300 em indivíduos normais: valor do registro simultâneo em Fz e Cz

Duarte

Alvarenga

Banhara

et al. 2009

Rev. Bras. Otorrinolaringol.

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O P300 é um Potencial Evocado Auditivo denominado potencial endógeno por refletir o uso funcional que o indivíduo faz do estímulo auditivo, sendo altamente dependente das habilidades cognitivas, entre elas atenção e discriminação auditiva. É um procedimento de avaliação objetiva, mas que depende da experiência do avaliador em detectar os picos das ondas, sendo importante a utilização de métodos de registro que facilitem a análise da presença de resposta e a interpretação dos resultados. OBJETIVO: Analisar o Potencial Evocado Auditivo de Longa Latência-P300 obtido com a utilização de dois eletrodos ativos posicionados em Fz e Cz. MATERIAIS E MÉTODOS: Participaram deste estudo 33 indivíduos de ambos os gêneros com idade entre 7 e 34 anos, audição normal e sem fator de risco para problemas mentais. RESULTADOS: Os resultados demonstraram que não houve diferença estatisticamente significante para a latência de N2 e P3 e amplitude do P3 quando analisado o gênero e nem correlação com a idade dos indivíduos. Houve forte correlação destas medidas com o posicionamento dos eletrodos em Fz e Cz. CONCLUSÃO: O posicionamento dos eletrodos ativos em Fz e Cz pode ser considerado um recurso a mais para auxiliar na análise clínica do P300.

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Auditory evoked potential development in early childhood: A longitudinal study

Cited by 65 publications

References 13 publications

The seed and the soil: effect of dosage, personality and starting state on the response to delta 9 tetrahydrocannabinol in man.

The seed and the soil: effect of dosage, personality and starting state on the response to delta 9 tetrahydrocannabinol in man.

The maturation of human evoked brain potentials to sounds presented at different stimulus rates

Potencial evocado auditivo de longa latência-P300 em indivíduos normais: valor do registro simultâneo em Fz e Cz

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